metabolism

The metabolism of cancer cells is reprogrammed toward aerobic glycolysis (the Warburg effect), which stimulates tumor growth. Phosphofructokinase (PFK) and its isoforms, PFKP, PFKM, and PFKL, are highly conserved central glycolytic controllers and a potential therapeutic intervention. This review discusses the complex functions of PFK in tumor biology, including its roles in regulating proliferat…

Fatty liver disease has become one of the fastest-growing health problems around the world. It happens when too much fat builds up inside the liver, an organ that plays a vital role in digestion, energy storage, and removing harmful substances from the body. While a small amount of fat in the liver is normal, excessive […] The post Liver Hormone Reverses Fatty Liver Damage, Study Finds appeared f…

Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit.

A new wave of scientific understanding is placing ferroptosis, a distinct form of iron-dependent cell death, at the forefront of efforts to overcome drug resistance in digestive cancers. These cancers, which include gastric, colorectal, liver, pancreatic, and esophageal malignancies, remain among the most challenging to treat due to their ability to evade standard therapies.

A new review article highlights the expanding importance of glutamine metabolism in shaping the tumor microenvironment, offering fresh perspectives on how metabolic interactions influence cancer progression and therapeutic response

A decades-old assumption about how the body handles fat may have been incomplete. For 60 years, scientists believed they understood exactly how a protein called HSL worked. Since the 1960s, hormone-sensitive lipase has been recognized as one of the body’s main fat-burning enzymes, helping release stored fat when energy is needed. But there was one [...]

Researchers say fructose is not just “empty calories” — it may actively push the body toward fat storage and metabolic disease. A new review found that fructose affects the body differently from glucose, disrupting normal energy regulation and promoting processes linked to obesity, insulin resistance, and cardiovascular problems.

BackgroundHepatocellular carcinoma (HCC) is a highly lethal malignancy with rising global incidence. Aberrantly activated aerobic glycolysis is a hallmark of HCC, driving excessive lactate production and the formation of an acidic tumor microenvironment (TME) that promotes malignant progression. Elucidating the underlying mechanisms of this metabolic axis is essential for developing targeted ther…

A key protein involved in fat metabolism has been found to do more than scientists once thought. Instead of just releasing fat, it helps maintain healthy fat tissue and balance in the body. When it’s missing or disrupted, the results can be surprisingly harmful. This finding reshapes how researchers think about obesity and metabolic disease.

A practical Metabolism submission guide for metabolic researchers evaluating their work against the journal's clinical and translational bar.

Most fat stores energy; the body's brown fat does the opposite. Unlike the white fat that accumulates just under our skin, brown fat burns calories and glucose to generate heat. Formally known as brown adipose tissue, it is a specialized metabolic tissue whose importance in adults has only come into focus in recent years. Brown fat--stored in small, distinct pockets deep within the body--plays an…

Prediabetes may leave a lasting molecular "footprint" on adipose (fat) tissue which appears to make maintaining weight loss after bariatric surgery more difficult, according to new research being presented at this year's European Congress on Obesity (ECO) in Istanbul, Turkey (12-15 May).

A new report, published today in Nature Metabolism, is shedding light on the distinct and underappreciated role of fructose in driving disease, separate from its role as a simple source of calories.

Bread and other carbohydrate staples may be doing more than just filling plates—they could be quietly reshaping metabolism. In a surprising twist, researchers found that mice strongly preferred carbs like bread, rice, and wheat, abandoning their regular diet entirely. Even without eating more calories, they gained weight and body fat, not because they overate, but because their bodies burned less…

Nature Communications, Published online: 13 April 2026; doi:10.1038/s41467-026-71985-w Author Correction: Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects

Scientists are investigating how exercise-triggered stress reshapes the cell’s energy systems, and whether those same mechanisms could eventually help counter metabolic disease. Don’t like the gym? Exercise scientist Ryan Montalvo gets it. He still goes anyway, because the physical strain of exercise often leads to lasting health benefits. Although workouts can feel intimidating, exercise trigger…

A new study observed the dual roles metabolism plays in fueling growth and signalling during cell development, and looked at how this process might be controlled.