biomarkers

ObjectiveTo explore features associated with impaired retinal neurovascular coupling among individuals diagnosed with Alzheimer’s disease (AD) and its association with alterations in plasma metabolomics, and to establish an integrated diagnostic model for evaluating its possible significance regarding early-stage identification of AD.MethodsWe prospectively enrolled 85 AD patients, 82 subjects wi…

Perioperative neurocognitive disorders (PND) after cardiac surgery are common complications that adversely affect postoperative recovery, functional independence, and long-term prognosis. Their pathogenesis is multifactorial, involving cerebral hypoperfusion, microembolism, CPB-related systemic inflammation, BBB disruption, oxidative stress, metabolic dysregulation, neuroimmune imbalance, and hos…

* New biomarkers may help monitor treatment responses to perioperative immunotherapy for patients with lung cancer * Researchers demonstrate that donor cord blood composition could influence outcomes of CAR NK cell therapy * Immune cell signaling plays important roles in skin cancer development, arthritis following immunotherapy treatment, and responses to rapid-acting antidepressants * The gut m…

Bacteria naturally release microscopic particles known as bacterial extracellular vesicles. This review considers how these vesicles could be adapted for precision cancer medicine, from carrying drugs and activating immune responses to limiting metastasis and identifying cancer biomarkers.

Renew Biotechnologies today announced the publication of its peer-reviewed research in Frontiers in Neurology, providing evidence that native DNA methylation analysis can identify neuron-associated cell-free DNA (cfDNA) signatures in blood across Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).

Diagnostics World | Blood-based biomarkers predicting when symptoms of amyotrophic lateral sclerosis (ALS) will emerge are expected to catapult the medical research community forward in the quest to prevent the fatal neurodegenerative disorder. Researchers from the University of Miami Miller School of Medicine have been spearheading the Pre-Symptomatic Familial ALS (Pre-fALS) study collecting lon…

Diagnostics World | Smartwatches could one day do more than track steps, sleep, and heart rate. Researchers at the University of California San Francisco (UCSF) are working with Samsung to determine whether physiological data collected passively by a smartwatch can help identify early changes in cognitive function.

Sino Biological Inc. is pleased to announce the launch of its Recombinant Human p-Tau217 Protein (Cat. No. T08-50SN), a full-length, tag-free Tau reagent developed to support Alzheimer’s disease biomarker assay development, antibody evaluation, and Tau biology research.

Nature Medicine, Published online: 31 July 2026; doi:10.1038/d41591-026-00039-x Amateur-level soccer players who ‘headed’ the ball during a single match showed immediate dose–response elevations in p-Tau217 and S100B in the blood.

The misfolding of the amyloid-β protein is the strongest blood-based predictor of Alzheimer’s disease in the asymptomatic stage. It indicates the risk years before clinical diagnosis and significantly earlier than the widely used plasma biomarker P-tau 217. This is the conclusion of a study led by P...

A central challenge in peripheral nerve injury care is determining whether an in-continuity injury will recover spontaneously or require early surgical intervention. This determination currently depends on serial observation, during which the window for effective intervention may narrow. This Perspective discusses grip strength as a translational biomarker for peripheral nerve injury and recovery…

Diagnostics World | Growing momentum in biomarker discovery, advancing analytical technologies, and a shift toward personalized medicine have created unprecedented possibilities for diagnostic development. The pace at which this progress translates to novel, widely adopted, clinically validated diagnostic tools remains slow, but not for lack of innovation.

Nature Medicine, Published online: 23 July 2026; doi:10.1038/s41591-026-04563-8 Early diagnosis of Alzheimer’s disease is important to ensure timely and accurate treatment. We show that a blood-based circular RNA signature can accurately detect Alzheimer’s disease as well as, or better than, current biomarkers and even predict who will develop symptoms before they appear. This less invasive appro…

Diagnostics World | Indole-3-propionic acid (IPA) is increasingly recognized as a critical chemical shield and promising biomarker for gut inflammation. Levels of IPA are starkly deficient in the blood of patients with active ulcerative colitis (UC), but the gold standard measurement technique of liquid chromatography-mass spectrometry (LC-MS) is costly and requires highly trained technicians to …

BackgroundEndothelial microvesicles (EMVs) carrying circular RNAs (circRNAs) have emerged as promising novel biomarkers of ageing-associated disorders. This study investigated the potential of plasma EMVs-circ_0006222 as vascular ageing (VA) and carotid atherosclerosis (CAS) biomarkers.MethodsA circRNA microarray was applied to screen for differentially expressed circRNAs in plasma EMVs obtained …

ViewsML, the Vancouver-based company developing what it calls the world’s first virtual biomarker library, closed an oversubscribed $4.9 million seed round earlier this year. Wittington Ventures, the Toronto venture arm of the Weston family holding company, led the round. New investors Mayo Clinic and Continuum Health Ventures participated alongside repeat backers including Debiopharm. In an… The…