stem-cell

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74058-0 In glioblastoma, matrix stiffness has been linked to poor prognosis and resistance to therapy. Here, the authors demonstrate that matrix stiffness drives radioresistance via upregulation of IQGAP3 promoting cancer cell stemness via SOX2 stabilization and show that blocking this interaction resensitises glioblast…

Chronic non-healing wounds, including diabetic ulcers, venous leg ulcers, and pressure ulcers, represent a significant clinical burden worldwide, associated with major economic costs and impaired quality of life. Although stem cell–based therapies have shown regenerative potential, recent accumulating evidence indicates that their therapeutic effects are primarily mediated by paracrine signaling …

If your Cell Stem Cell manuscript shows Under Review, here is what the editor and reviewers are likely doing and when to follow up.

Platelet-rich plasma or PRP is a regenerative product that has grown in popularity. The literature on clinical applications of PRP is all over the place. Whether it works or not for any particular application is unclear to me. Many orthopedists seem enthused about it. I haven’t seen any major adverse events linked to PRP. PRP […] The post Weekly reads: odd FDA PRP warning, H3.3 & CTCF, Iowa AG ge…

Have we reached the reproductive frontier of lab-grown sperm? Producing oocytes in the lab has always been thought to be the initial focus in this arena. It was thought that figuring out the way to maked lab-grown sperm would take longer. Now a new report suggests both sperm and eggs can be made by in […] The post Weekly reads: lab-grown sperm, stem cell pills, intranasal EVs, EMF Cell paper doub…

Cell Stem Cell impact factor is 20.4 with a 5-year JIF of 21.8. See the rank, trend, and what that number means before submission.

Toward the end of each year I make predictions for the stem cell and regenerative medicine field for the coming year. I’ve been doing this in some form for more than a dozen years. In today’s post I grade my 2025 predictions for the regenerative arena. Overall, the crystal ball didn’t disappoint even if the […] The post Grading my 25 stem cell & regenerative medicine predictions for 2025 appeared…

Cartilage regeneration has been a holy grail for the stem cell field for decades. It has mostly been just out of reach though. Even most unproven stem cell clinics have stopped claiming to regrow cartilage in joints. For instance, a typical clinic that now injects PRP or cells into arthritic knees doesn’t claim to regrow […] The post Weekly reads: cartilage regeneration, ferroptosis, Aspen Neuros…

After years of legal battles, the FDA has secured what appears to be a decisive federal court victory in its effort to regulate one type of stem cell clinic. This ruling has implications for other clinics too. The U.S. Supreme Court just declined to review a key case that the FDA had won on appeal […] The post FDA secures major win as SCOTUS lets stem cell clinic ruling stand appeared first on Th…

Both Japan’s regenerative medicine framework and the system of FDA-centric oversight here in the US have allowed large numbers of unproven stem cell clinics to flourish. While the US stem cell clinic problem has gotten major attention, many in the field may not realize that there may be hundreds of unproven clinics that offer biologics […] The post Woman dies after unproven regenerative medicine …

It’s been a big couple of weeks of chaotic developments at the FDA including the ousting of CBER director Vinay Prasad. The Sarepta rollercoaster was tied to that. If such recent events are any indication of how the next 3+ years are going to play out at the agency, it’s going to be negative for […] The post Weekly reads: aging & stem cells, FDA disarray, bad stem cell headline of the week appear…

Stem cells can be serious business, but sometimes stories come along that are just fun like a lady running a marathon dressed as a stem cell. How cool is this: “Louise Cato from Somerset is doing the run to raise money for the charity Anthony Nolan, after her dad had a bone marrow transplant over […] The post Weekly reads: stem cell marathon, Ray Therapeutics, stem cells making you fat? appeared …

I had a feeling late last year that I’d frequently be writing about RFK Jr. and his impact on the FDA. However, I didn’t realize some of that would be writing for STAT News. As I mentioned a few days ago, I now have a new regular column over there. I thought the column would […] The post Weekly reads: RFK Jr. stem cell summit, FDA OKs eye cell therapy, cartilage repair appeared first on The Niche…

Did you predict the major events in the stem cell and regenerative medicine field this year? I tried and today’s post are the grades on my predictions. Prediction is a key part of being a scientist even if we may not think about it that much. For instance, we have to try to predict what […] The post Grading my 20 stem cell & regenerative medicine predictions for 2024 appeared first on The Niche .

After a bit of a hiatus in 2024, our  list of regenerative medicine and stem cell meetings returns for 2025. I’m noticing a lot of great stem cell meetings already scheduled for 2025. With the pandemic being less of an ever-present thing, most meetings are now only in-person these days. In a way, the hybrid […] The post 2025 regenerative medicine and stem cell meetings list appeared first on The …

There should be more stem cell awards. Why not recognize more scientists and advocates? I used to do a Stem Cell Person of the Year Award. I have thought about bringing it back. What do you think? Scroll through some past posts on the Stem Cell Person of the Year Award. ISSCR gives out stem […] The post Weekly reads: Rusty Gage & stem cell awards, ASCL1, stem cells for a vulture appeared first on…

New research on stem cell patches is exciting. However, more broadly, “stem cell patches” can mean very different things. What I’m talking about here are the types of patches that can repair holes or other problems with tissues. This is a powerful regenerative approach. In contrast, I’m not a fan of the type of stem cell […] The post Weekly reads: stem cell patches, helicase editing, hearing loss…

Back in late August, Liveyon leader John Kosolcharoen pleaded to federal charges on stem cells. What was Liveyon? Liveyon was a splashy umbilical cord stem cell supplier company. I don’t know if the company is still active now. One of its core products ended up sending dozens of people to the hospital due to contamination […] The post Liveyon made $21.6 million says DOJ; leader gets 3 years priso…

It’s always fun to see startups with cool ideas in the regenerative medicine space and a new one called GC Therapeutics got some nice coverage this week. What do you think the name of this firm stands for? I have one main idea I mention below. Before we jump into it, I want to introduce […] The post Weekly reads: George Church’s stem cell startup GC Therapeutics, coral for knees, blast from the p…

Some of you might remember the stem cell clinic firm R3 Stem Cell. I have major concerns about some of what they are marketing including in the U.S. I was reminded of R3 Stem Cell again just now. The Associated Press (AP) ran a PR on R3 Stem like it was a news story.  I […] The post Media like the AP promote unproven stem cell clinics such as R3 Stem Cell appeared first on The Niche .