stem-cell

A long-standing rule in stem cell transplantation is being challenged. New ACCESS trial findings in Blood Advances show encouraging outcomes with younger, more genetically mismatched unrelated donors. Lead author Antonio Jimenez Jimenez, M.D., can discuss how the findings are reshaping donor selection and patient care.

Ovarian aging is a complex biological process traditionally attributed to the progressive depletion of the follicular reserve. However, accumulating evidence suggests that age-related reproductive decline is not solely determined by follicular loss but also by profound alterations in the ovarian microenvironment, including stromal fibrosis, vascular dysfunction, chronic low-grade inflammation, ox…

When a patient needs a stem cell transplant, finding a registered donor is only the first step. Some potential donors drop out before confirmatory typing, reducing the pool from which doctors can choose.

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74058-0 In glioblastoma, matrix stiffness has been linked to poor prognosis and resistance to therapy. Here, the authors demonstrate that matrix stiffness drives radioresistance via upregulation of IQGAP3 promoting cancer cell stemness via SOX2 stabilization and show that blocking this interaction resensitises glioblast…

Chronic non-healing wounds, including diabetic ulcers, venous leg ulcers, and pressure ulcers, represent a significant clinical burden worldwide, associated with major economic costs and impaired quality of life. Although stem cell–based therapies have shown regenerative potential, recent accumulating evidence indicates that their therapeutic effects are primarily mediated by paracrine signaling …

Platelet-rich plasma or PRP is a regenerative product that has grown in popularity. The literature on clinical applications of PRP is all over the place. Whether it works or not for any particular application is unclear to me. Many orthopedists seem enthused about it. I haven’t seen any major adverse events linked to PRP. PRP […] The post Weekly reads: odd FDA PRP warning, H3.3 & CTCF, Iowa AG ge…

Did you predict the major events in the stem cell and regenerative medicine field this year? I tried and today’s post are the grades on my predictions. Prediction is a key part of being a scientist even if we may not think about it that much. For instance, we have to try to predict what […] The post Grading my 20 stem cell & regenerative medicine predictions for 2024 appeared first on The Niche .