regenerative-biology

Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, an…

Why can zebrafish regenerate damaged gut nerves while humans largely cannot? Michigan State University researchers have developed a powerful new research tool that allows them to remove gut neurons in zebrafish and watch them regenerate in real time, helping scientists investigate one of regenerative biology’s biggest questions. The research focuses on the enteric nervous system, … The post New t…

Toward the end of each year I make predictions for the stem cell and regenerative medicine field for the coming year. I’ve been doing this in some form for more than a dozen years. In today’s post I grade my 2025 predictions for the regenerative arena. Overall, the crystal ball didn’t disappoint even if the […] The post Grading my 25 stem cell & regenerative medicine predictions for 2025 appeared…

Did you predict the major events in the stem cell and regenerative medicine field this year? I tried and today’s post are the grades on my predictions. Prediction is a key part of being a scientist even if we may not think about it that much. For instance, we have to try to predict what […] The post Grading my 20 stem cell & regenerative medicine predictions for 2024 appeared first on The Niche .

Professor Paul Knoepfler·Ph.D.
12/17/2024

Toward the end of each year I make predictions for the stem cell and regenerative medicine field for the coming year. I’ve been doing this for more than a dozen years in various forms. In this post I’m looking at the (gene-edited, stemness enriched) tea leaves for 2025 for the regenerative arena. These predictions include […] The post 25 stem cell & regenerative medicine predictions for 2025 appe…

Do many in the regenerative medicine field have favorite types of stem cells? Some seem to think there’s a tension between those working on pluripotent stem cells like iPS cells and those working with MSCs. I don’t see it that way, though. Whatever stem cells work best for a particular condition should be used and, […] The post Weekly reads: diabetes, GvHD, Novo Nordisk & regenerative medicine, H…

The past year was all over the place for the stem cell and regenerative medicine field. As you can see in my scoring of my 21 predictions for 2021, quite a few things were surprises in terms of what did and didn’t happen. Here’s an overview of the top stories of the year in our […] The post Top stem cell stories of 2021: COVID, diabetes, human embryos, clinics in court appeared first on The Niche…

Why is the liver the only human organ that can regenerate? How does it know when it’s been injured? What can our understanding of the liver contribute to regenerative medicine? These are just some of the questions that new assistant professor of biology Kristin Knouse and her lab members are asking in their research at […] The post 3 Questions: Kristin Knouse on the liver’s regenerative capabilit…

Planarians are small water-dwelling worms known for their regenerative capacity. If you chop one into ten pieces, you’ll end up with ten fully-formed worms. While humans have pools of specialized stem cells that can create our regenerative body parts like hair and skin, these worms owe their regenerative superpowers to a special kind of stem […] The post These worms’ stem cells are developmental …