transplantation

Innovative hydrogel cloaking of islets could revolutionize diabetes therapy, allowing for effective cell transplantation without compromising immune function.

The Ochsner Transplant Institute has performed its 10,000th organ transplant, becoming the first and only transplant center in Louisiana to reach this milestone. The achievement reflects decades of clinical excellence, innovation and compassionate care, made possible by organ donors, patients, families and dedicated care teams.

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

BackgroundTacrolimus (TAC) exhibits high pharmacokinetic variability post-liver transplantation (LT). Traditional models overlook the metabolic chimerism between recipient (intestinal) and donor (hepatic) genotypes. We aimed to evaluate a combined donor–recipient CYP3A functional allele count predicting TAC exposure.MethodsThis retrospective study analyzed 1,350 TAC trough measurements from 99 LT…

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

Immunosuppressive medications help prevent organ rejection following transplantation, yet some patients still experience rejection despite receiving adequate treatment. New research from Yale, published in the Journal of Clinical Investigation, identifies a potential genetic mechanism underlying the increased risk in some patients of recent African ancestry, revealing changes in immune cell signa…

Baylor College of Medicine today announced that a new research agreement with United Therapeutics Corporation, a public benefit corporation, will provide up to $5 million a year for five years to establish the Baylor College of Medicine Center for Xenoliver Transplantation and Immunomodulation (XTI), dedicated to advancing scientific understanding of xenoliver transplantation.

A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine approaches to treat organ rejection.

The U-M Health Liver Transplant Program is dedicated to decreasing waitlist time to improve patient outcomes

Robert Lindemann is a 32-year-old accountant from Germany. He’s also had a heart transplant, a life-changing experience shared by just a few hundred people each year in his country.  But at the Transplant Games, he doesn’t stand out — and that’s something of a relief. “It sounds a bit weird... The post The ‘Transplant Games’ Are About More Than Medals appeared first on Reasons to be Cheerful .

An international research team led by the Medical University of Vienna reports on a new treatment strategy that has made a kidney transplant possible for a patient with no realistic chance of receiving a suitable donor organ.

Adults with kidney transplants who were treated for COVID-19 with the antiviral remdesivir within a week of COVID-19 diagnosis and who received at least three consecutive days of therapy were less likely than kidney transplant recipients who did not receive the antiviral to experience cardiovascular or kidney problems up to a year later, according to findings from a target trial emulation study t…

A groundbreaking device capable of sustaining donated lungs outside the body for up to six hours has been given the green light for NHS use. The XVIVO Perfusion System, which replicates natural bodily processes including respiration and blood circulation, received approval from the National Institute for Health and Care Excellence in draft guidance as further evidence on its efficacy is gathered.…

(MIT Technology Review) – Kidneys kept at subzero temperatures in pressure-controlled containers can be stored for days before transplantation, raising hopes for longer-term storage of donated human organs. In most cases, organs will be kept on ice during that time, … Read More

Purpose Kidney transplantation remains the best treatment option for end-stage renal disease. However, despite overall improvements in patient and graft survival rates after kidney transplantation, differences in outcomes still exist among different racial and ethnic groups, with African-Americans having lower graft survival. Gaps continue to exist in the understanding of how demographic factors …

More than 100,000 people in the United States are waiting for a lifesaving organ transplant. For patients in need of a liver transplant, determining whether a donor liver is healthy enough to transplant is a critical part of the process.

Northwestern Medicine surgeons have performed the first known quadruple-organ transplant involving retransplanted lungs in the United States. Elizabeth Wehrle, a 36-year-old mother from Montezuma, Iowa, received two donor lungs for a second time, along with a liver and kidney, after complications from cystic fibrosis and chronic rejection of her first lung transplant left her critically ill.

Researchers at Mayo Clinic, in collaboration with the Terasaki Institute for Biomedical Innovation, have developed a real-time monitoring system designed to give transplant teams a more complete picture of a donor liver's health during machine perfusion.