transplantation

Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely understood.

ObjectiveIn recent years, fecal microbiota transplantation (FMT) has been increasingly investigated for the prevention and treatment of acute graft-versus-host disease (aGVHD). Nevertheless, its clinical efficacy remains uncertain. Therefore, this study aims to systematically evaluate the clinical efficacy of FMT in preventing and treating aGVHD.MethodsWe systematically searched Cochrane Library,…

A simple blood test could one day replace invasive biopsies for detecting acute cellular rejection (ACR) after lung transplantation, a recent American Journal of Transplantation study finds.

Jasmine Jones, battling cystic fibrosis since infancy, underwent a quadruple-organ transplant at UChicago Medicine. With the help of a new kidney, liver and pair of lungs -- all from the same donor -- the 28-year-old has a new lease on life.

BackgroundTacrolimus shows substantial interindividual pharmacokinetic variability, complicating dose individualization in renal transplantation. The tacrolimus trough concentration-to-dose-to-weight ratio (C0/D/W) has been proposed as a simple surrogate of tacrolimus bioavailability, yet the extent to which pharmacogenetic and clinical factors explain this phenotype in stable adult kidney transp…

Nature Communications, Published online: 11 May 2026; doi:10.1038/s41467-026-73043-x Author Correction: Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection

A lucky mother has had the incredible opportunity to hold her late daughter's hand once again, after meeting with the woman who received it in a transplant. Jackie Kirwan, 65, lost Georgie Peterson in August 2025, who lived with a rare brain disorder called periventricular nodular heterotopia (PVNH), causing debilitating seizures. Ms Peterson, from Liverpool, had been on the organ donation regist…

RayMond Hamilton and Sheila Campbell have known each other since they were kids growing up in Fort Worth. Decades after they first met, Sheila would be there for RayMond in the most meaningful way - donating one of her kidneys to save his life following his two-plus-year ordeal with chronic kidney disease.

Scientists are making a major leap toward freezing organs for future use without damaging them. A new study reveals that one of the biggest obstacles—cracking during ultra-cold preservation—can be reduced by carefully tuning the temperature at which tissues enter a glass-like state. This breakthrough builds on recent successes in cryopreserved organ transplants and could bring the long-imagined i…

Advances in pediatric heart care are helping more children survive long enough to receive a transplant-but a critical shortage of donor hearts means too many are still dying while they wait, experts warned today at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.

As demand for heart transplants continues to far exceed the number of available donor hearts, experts at today's 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) explored a critical question: how should this scarce, life-saving resource be allocated?

Today at the 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Eileen Hsich, MD, of the Cleveland Clinic, outlined a bold vision for the future of heart transplantation that moves beyond national borders to address global inequities in organ allocation.

Today at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual meeting and Scientific Sessions, transplant specialists Brian Keller, MD, PhD, and Thomas Egan, MD debated an ethically fraught question: How old is too old for a lung transplant?

Every second counts in the life-saving world of medical transplants. To help address that urgency, NASA’s Langley Research Center in Hampton, Virginia, is teaming up with the United Network for Organ Sharing (UNOS) to explore faster, more reliable ways to transport donor organs using advanced aviation technologies.  NASA Langley and UNOS will collaborate under a new Space Act Agreement announced …

UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a unique "immune priming" therapy.

People who have elevated levels of donor-specific anti-HLA antibodies (DSAs) -- immune system proteins that can target and attack donor stem cells -- wait an average of three additional months to receive blood or bone marrow transplants from a healthy donor, according to recent research from investigators at the Johns Hopkins Kimmel Cancer Center. Those most likely to be affected are Black women …

By developing precise techniques to stitch blood vessels and restore their function, Carrel made it possible to maintain blood flow during surgery and laid the foundation for modern vascular repair and organ transplantation

Scientists from Great Ormond Street Hospital and UCL have created the first lab-grown oesophagus and have implanted it in pigs, … read more