Integrating pharmacogenetic and clinical factors to predict the C0/D/W-based tacrolimus phenotype in kidney transplantation

BackgroundTacrolimus shows substantial interindividual pharmacokinetic variability, complicating dose individualization in renal transplantation. The tacrolimus trough concentration-to-dose-to-weight ratio (C0/D/W) has been proposed as a simple surrogate of tacrolimus bioavailability, yet the extent to which pharmacogenetic and clinical factors explain this phenotype in stable adult kidney transplant recipients remains unclear.MethodsWe conducted a single-centre retrospective study including 77