Glioblastoma is a malignant brain tumor and is among the most aggressive cancers in humans. Despite multimodal therapy with surgery, radiation and chemotherapy, there is still no cure. A major reason is the tumor’s invasive behavior: Glioblastoma cells migrate far beyond the visible tumor into healthy brain tissue. These infiltrating cells cannot be completely removed […]
Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74058-0 In glioblastoma, matrix stiffness has been linked to poor prognosis and resistance to therapy. Here, the authors demonstrate that matrix stiffness drives radioresistance via upregulation of IQGAP3 promoting cancer cell stemness via SOX2 stabilization and show that blocking this interaction resensitises glioblast…
