Frontiers in Psychiatry | New and Recent Articles

ObjectiveTo evaluate the effects of various transcranial magnetic stimulation (TMS) parameters—including stimulation duration, intensity, pulse number, frequency, and target region—on pain scores in patients with neuropathic pain (NP).MethodsRandomized controlled trials (RCTs) assessing the effects of TMS on NP were identified through searches of PubMed, Embase, Web of Science, and the Cochrane L…

IntroductionThe long-term efficacy of electroacupuncture (EA) in treating cognitive symptoms of Alzheimer’s disease (AD) remains unclear, and its time-dependent relationship requires further investigation.MethodsSixty-six patients were allocated to the EA or sham EA group, with stimulation for 20 minutes, for a 24-week treatment period, and were followed-up at 4 weeks. The primary outcome was the…

Poststroke anxiety and depression (PSAD/PSAnx) are common and heterogeneous emotional disorders among stroke survivors, significantly impacting functional recovery, quality of life, and long term prognosis. Their pathogenesis is complex and multifactorial, involving neurobiological alterations, cognitive dysfunction, behavioral responses, and social environmental factors. Cognitive impairments, f…

IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and cerebral spinal fluid (CSF) autoantibodies with other routine and novel markers of neuroinflammation, including CSF cytokines in patients with atypical psychiatric presentations of…

BackgroundNon-suicidal self-injury (NSSI) has become an increasingly prominent mental health problem during adolescence and often co-occurs with depressive symptoms, anxiety, personality-related difficulties, and experiences of childhood trauma, forming a complex psychosocial risk structure. From a risk and protective factor perspective, the present study examined the associations among adverse c…

The rapid adoption of AI chatbots for emotional support and quasi-therapeutic interaction raises questions that existing clinical and regulatory frameworks are not equipped to address. This Perspective applies the psychic arbitrage framework—which reconceptualizes defense mechanisms as energy-conversion operations on internal psychic markets—to analyze the specific transactional distortions produ…

BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons, which results in motor issues such as tremors, stiffness, and slowness of movement. In addition to experiencing non-motor symptoms like psychosis. Catatonia, a psychomotor syndrome that is resulted from dopamine and cerebral cortical dysfunction, is considered a rare manifes…

BackgroundVaping among adolescents has decreased but remains common among young adults, with ongoing concerns about nicotine health risks. Public health campaigns have increased vaping prevention messages, but evidence on their effectiveness, especially on cognitive and behavioral outcomes, is limited.ObjectiveThis systematic review and meta-analysis aimed to synthesize recent experimental eviden…

IntroductionTic disorders (TDs) are common neurodevelopmental conditions with unclear pathogenesis and a lack of objective biomarkers. This study aimed to explore the associations among circulating microRNAs (miRNAs), erythroid phenotypes, iron homeostasis, and pediatric TD.MethodsA total of 30 TD children and 10 healthy controls were enrolled. Serum levels of five candidate miRNAs, erythroid par…

BackgroundAdolescents with depressive disorders are at elevated risk for adverse mental health outcomes, and excessive Internet use has been increasingly linked to greater symptom severity. Therefore, this study aimed to examine the chain mediating roles of social anxiety and sleep quality in the association between excessive Internet use and depressive symptoms among adolescents with depressive …

IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure patterns, differ across dementia subtypes among older adults with both conditions.MethodsWe analysed anonymised electronic health records from a south London catchment area. We inclu…

ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.MethodsElderly patients with depressive disorder and OSAHS were consecutively enrolled from January to December 2025. A Gower distance matrix was constructed and phenotypes were deriv…

BackgroundSleep problems, including daytime sleepiness, short sleep duration, and poor sleep quality, are strongly associated with suicidality in non-autistic people. Sleep difficulties are also common in Autistic children and adolescents (herein, youth), affecting 40-80%, and may contribute to their elevated suicide risk, which emerges as early as 10 years of age and is 3.5 times higher than the…

BackgroundPhysical health is the basic indicator to evaluate the health of drug addicts after the process of drug rehabilitation. In order to better improve the deficiency degree of physical health of drug addicts, it is necessary to carry out a systematic review.ObjectiveTo explore the effects of exercise intervention on the physical health of individuals undergoing compulsory drug rehabilitatio…

BackgroundInsomnia is highly prevalent among perimenopausal women and exerts detrimental effects on physical health, psychological well-being, and overall quality of life. However, its underlying mechanisms remain incompletely understood. This cross-sectional study aimed to identify factors associated with insomnia in perimenopausal women.MethodsA total of 187 perimenopausal women aged 45–55 year…

This paper introduces RecoveryWorks, a multi-system recovery and vocational support program designed to expand the therapeutic landscape of recovery by increasing access to career development resources that support meaningful employment. In contrast to vocational approaches that prioritize rapid job placement, RecoveryWorks embeds work within a recovery-oriented system of care. By linking the und…

BackgroundDepressive disorders are clinically heterogeneous and mechanistically complex psychiatric conditions. Transcranial direct current stimulation (tDCS), a key non-invasive neuromodulation technique, has expanded rapidly in both therapeutic application and mechanistic research. However, the field is marked by rapid publication growth, thematic diversity, and variability in evidence quality.…

BackgroundNonsuicidal self-injury (NSSI) is heterogeneous, yet clinically useful exploratory subgrouping remains limited. We examined whether motivational and addiction-like features could delineate meaningful data-driven NSSI profiles and relate to clinically relevant outcomes.MethodsWe clustered six motive dimensions of the Ottawa Self-Injury Inventory (OSI; F1–F6) and an addiction-like score i…

ObjectiveTo explore the mechanisms underlying depressive symptoms among college students, develop a targeted intervention based on the proposed model, and provide empirical support for university mental health education.MethodsThis study examined the relationships between positive and negative parenting styles and depressive symptoms among college students, with interpersonal efficacy and meaning…