toxicology

Liver and kidney, as the core metabolic detoxification organs of human body, rely on specific biofilm barrier and metabolic enzyme system to form metabolic barrier respectively. This metabolic barrier is the key defense line to resist the invasion of drugs and environmental poisons. There are significant differences in the structural function and toxic response mechanism of the metabolic barrier …

Many people use products every day without thinking about the chemicals inside them. Nonstick pans, stain-resistant carpets, and water-resistant clothing all contain substances designed to make life easier. However, some of these substances may come with hidden health risks. A group of chemicals called PFAS has recently attracted attention from scientists. These chemicals are widely […] The post …

Fuzi, the processed lateral root of Aconitum carmichaelii Debeaux (Ranunculaceae), is a vital yet highly toxic botanical drug in traditional Chinese medicine. However, its narrow therapeutic window, driven by highly toxic diester-diterpenoid alkaloids (DDAs), necessitates rigorous processing. Adhering to the four pillars of best practice in ethnopharmacology, this review systematically evaluates …

The study identifies critical windows of metal exposure via baby teeth, revealing impacts on brain development and behavior in children and adolescents.

New studies highlight sex differences in biological responses to PCB exposure and highlight the protective effect of folic acid

By analyzing layers in these teeth, scientists have pinpointed a critical window when baby brains are most vulnerable to toxic metals — and linked that to behavior problems later in life.

This review examines how e-cigarette aerosols may disrupt testosterone through microRNA-mediated control of HPG axis signaling and Leydig cell function, revealing a regulatory layer that may precede detectable hormonal changes.

Acetamiprid (ACMP) is a widely used neonicotinoid insecticide that has been linked to oxidative stress-induced toxicity and physiological changes in mammals. This study investigates ACMP-induced hepatic and testicular toxicity in rats and the potential protective role of Chlorella vulgaris (C. vulgaris), a green microalga used as an antioxidant against ACMP-induced toxicity. Thirty-two male rats …

Our review examines how e-cigarette aerosol constituents may disrupt Leydig cell testosterone synthesis through oxidative, mitochondrial, inflammatory, and epigenetic mechanisms, while highlighting the current gap between strong preclinical evidence and limited human data.

IntroductionDrug-induced liver injury (DILI) is a major cause of morbidity and mortality and has an important impact on drug attrition. Recent guidelines from the FDA and previous research encourage the development of virtual twin in silico modeling as a solution to reduce DILI impact.MethodsIn this study, we used our virtual, scalable model of the human liver lobule coupled with an acetaminophen…

IntroductionOral leukoplakia (OLK) is a prevalent oral potentially malignant disorder with limited treatment options. Our previous research showed that Azoxystrobin (AZOX) induces apoptosis and inhibits mitochondrial complex III activity. Peroxiredoxin 1 (Prx1) plays an important role in OLK progression, and preliminary evidence suggests AZOX may target Prx1 to disrupt mitochondrial function. Thi…

Scientific Reports, Published online: 16 April 2026; doi:10.1038/s41598-026-48814-7 Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications

Toxicology and chemical safety in Indonesia are governed by strict regulations, particularly regarding the registration of hazardous substances (B3) manufactured or... The post Toxicology Methods for Chemical Safety in Indonesia appeared first on Food Research Lab .

Exposure to supposedly safer alternatives to traditional forever chemicals during early development causes lasting cognitive problems in adult rats. Emerging research suggests these widely used synthetic compounds can severely disrupt the physical construction of the mammalian brain.