endocrinology

Clinical obesity is reconceptualized in this manuscript as a structural affective–endocrine disorder emerging from a chronic fusion of two Core Emotion Framework (CEF) operators: Expanding and Accepting. This maladaptive “Expand–Accept” fusion produces a passive coping metabolic phenotype characterized by boundaryless somatic openness and involuntary yielding, described in the text as “a boundles…

IntroductionDiabetes mellitus (DM) is a multifaceted disease etiologically characterised by dysregulation in glucose homeostasis. The World Health Organization (WHO) global report indicates that over 90% of DM cases are classified as Type 2 DM (T2DM), which is clinically characterized by chronic hyperglycemia. This systemic condition arises predominantly due to the interplay of two key components…

Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders in women of reproductive age. It can cause irregular periods, infertility, weight gain, insulin resistance, and elevated male hormone levels. Current treatments mainly focus on managing symptoms rather than addressing underlying causes.

Patients with hypothyroidism--an underactive thyroid gland--may face significant risk of developing small intestinal bacterial overgrowth (SIBO), according to research led by Cedars-Sinai Health Sciences University investigators.

Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combin…

Polyendocrine Metabolic Syndrome (PMOS), formerly PCOS, is the most common hormonal and metabolic disorder in women of reproductive age, affecting up to 13% and contributing to nearly 40% of infertility cases. FAU researchers reviewed more than 2,200 studies and identified 29 focusing on non-pharmacological care in midlife and reproductive aging.

Type 2 diabetes has become one of the biggest global health problems of modern times. More than half a billion people worldwide are currently living with diabetes, and most of them have type 2 diabetes. The disease is becoming more common as populations grow older and lifestyles change, including less physical activity, increasing obesity, and […] The post Why insulin-producing cells eventually s…

Thomas Delong , PhD, moved to Colorado from Germany two decades ago intent on one thing: understanding the origin of type 1 diabetes (T1D) and finding ways to stop it. Diagnosed at age 12 with the disease that affects 9.5 million people worldwide, Delong’s mission was deep-rooted and personal.

For decades, scientists studying type 2 diabetes have focused mainly on insulin. Insulin is the hormone that helps move sugar out of the blood and into the body’s cells so it can be used for energy. When the body stops responding properly to insulin, blood sugar levels slowly rise, leading to type 2 diabetes. But […] The post This hidden hormone problem may trigger type 2 diabetes appeared first …

A new study from researchers in Germany has uncovered another possible cause of type 2 diabetes, and it may begin in the liver rather than the pancreas alone. Scientists have found that people with newly diagnosed type 2 diabetes have unusually high levels of a hormone called glucagon, especially when they also have fatty liver […] The post Fatty liver disease may cause type 2 diabetes through th…

Hormones influence how we feel -- happy, sad or hungry -- and profoundly shape how our bodies function and respond to disease.

For 14 years, Grace Hamilton lived with an undiagnosed disease that left her feeling frustrated and alone. Misunderstanding from other kids marked her youth, along with subtle disappointment from her parents, who had no idea that her climbing weight and fluctuating emotions were largely disease driven.

A multiyear effort to rename polycystic ovary syndrome finally revealed the condition’s new name: polyendocrine metabolic ovarian syndrome

Drs. Sistla and Manivannan play key roles in multidisciplinary program managing complex adrenal disease through coordinated evaluation, treatment, and education

For many years, scientists studying type 2 diabetes have mainly focused on one hormone: insulin. Insulin is produced by the pancreas and helps move sugar from the blood into the body’s cells, where it can be used for energy. In people with type 2 diabetes, the body slowly becomes less sensitive to insulin, a condition […] The post Scientists find another hormone behind type 2 diabetes—and the liv…

Heart disease risk has been found to increase in women with polycystic ovary syndrome (PCOS), even in those with normal weight, according to research presented at the 28th European Congress of Endocrinology in Prague.

Researchers found that MASLD, rather than type 2 diabetes alone, was linked to higher fasting glucagon levels in adults with newly diagnosed diabetes and matched controls. In people with early type 2 diabetes, higher liver fat was specifically associated with exaggerated early post-meal glucagon responses, independent of insulin sensitivity, visceral fat, amino acids, or NEFAs.

Some clinicians are pushing to broaden testosterone use, but there is debate about its benefits and risks

A Field in Motion: Growing Opportunity for Therapeutic Innovation For biopharma sponsors, scientific clarity, measurable outcomes, and ease of regulatory validation are important factors to consider when developing new therapies. As the industry focus on precision medicine and orphan drug innovation continues to grow, rare endocrine system disorders emerge as a strategically important area for [……