Integrating evidence-based lifestyle and adjunct therapies for long-term management of polycystic ovary syndrome: mechanistic insights and clinical implications
Venkatraman Manickam
BackgroundPolycystic ovary syndrome (PCOS) is a complex multisystem disorder affecting 6%–13% of reproductive-aged women, characterized by hormonal and metabolic dysregulation. Driven by hyperandrogenism and insulin resistance, it contributes to reproductive and cardiometabolic complications. Current management remains largely symptom-focused, often limiting long-term effectiveness and comprehensive disease control.Objective and rationaleThis narrative review critically evaluates current evidenc