inflammatory-bowel-disease

IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal barrier dysfunction and epithelial cell death. Necroptosis of intestinal epithelial cells (IECs) mediated by the RIPK1/RIPK3/MLKL pathway has emerged as a key driver of UC progression. Celastrol, a bioactive compound from Celastrus wilfordii, has shown anti-inflammatory potential, but its effec…

When people think about inflammatory bowel disease, they usually think about digestive symptoms such as stomach pain and diarrhea. However, a new study suggests the condition may also affect mental health long before doctors recognize the disease. The research was published in Clinical Gastroenterology and Hepatology. IBD is a lifelong illness in which the immune […] The post Depression and Anxie…

IntroductionUstekinumab is an effective biologic therapy for inflammatory bowel disease (IBD), yet many patients experience loss of response requiring dose escalation. Predictors of ustekinumab dose escalation remain poorly defined, particularly across Crohn’s disease (CD) and ulcerative colitis (UC).MethodsWe conducted a retrospective cohort study to includ adult patients with IBD initiated on u…

BackgroundThis study investigated the protective effects of Anacyclus pyrethrum L. (AP) in a dextran sulfate sodium (DSS)-induced colitis mouse model and explored its potential associations with intestinal barrier function, inflammatory responses, gut microbiota, and fecal metabolic profiles.MethodsDSS-induced colitis mice were treated with different doses of AP aqueous extract. Disease activity,…

Inflammatory Bowel Disease (IBD) is a chronic relapsing inflammatory condition of the intestine, characterized by symptoms such as chronic diarrhea, abdominal pain, and weight loss. The pathogenesis of IBD is complex, with mitochondrial dysfunction being considered a key factor in its onset, progression, and persistence. Mitochondria, as the primary energy suppliers within cells, not only produce…

Scientists identified an autoimmune mechanism linked to a major IBD risk gene, opening the door to targeted diagnosis and personalized therapies for thousands of patients. For decades, inflammatory bowel disease (IBD) has been treated as a single disorder, even though patients often experience dramatically different symptoms, disease courses, and responses to therapy. A new study [...]

Inflammatory bowel disease, often called IBD, is a chronic condition that causes inflammation in the digestive tract. The two main forms of IBD are Crohn’s disease and ulcerative colitis. These conditions can cause symptoms such as abdominal pain, diarrhea, fatigue, weight loss, and reduced quality of life. Although researchers have made significant progress in understanding […] The post Certain …

Aim of the StudyTo observe the efficacy and safety of CQE in rapidly alleviating inflammatory activity in UC.Materials and MethodsCQE extracts were analyzed by UHPLC–Q Exactive Orbitrap–HRMS. This study used a self-controlled design before and after treatment. A total of 114 UC patients were included and treated with traditional rectal enema administration of CQE. Among them, 107 patients complet…

Mayo Clinic researchers have identified an immune-regulating molecule that may help explain why some patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, do not respond to commonly used therapies.

Many people living with inflammatory bowel disease experience a frustrating problem. Even after their condition is treated and inflammation improves, they continue to have symptoms like stomach pain, bloating, and irregular bowel movements. These symptoms often resemble irritable bowel syndrome and can greatly affect quality of life. Until recently, doctors did not have a clear […] The post Gut i…

Scientists have uncovered an unexpected mechanism by which the gut’s immune system maintains balance, challenging long-standing assumptions about how immune tolerance is regulated. Researchers at Weill Cornell Medicine have uncovered an unexpected mechanism the immune system uses to prevent chronic inflammation in the intestine. The discovery could point to new treatment strategies for inflammato…

IntroductionUlcerative colitis (UC) is one of the predominant forms of inflammatory bowel disease (IBD), and it is a chronic and recurring inflammation of the gastrointestinal trac. However, the therapies are associated with drug resistance and low responsiveness. Ferulic acid (FA) alleviates clinical signs and inflammatory mediators in UC, while the molecular mechanisms of FA regulation on UC re…

Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease, according to a study published in Nature Immunology. The post How a Common Metabolite Worsens Inflammatory Bowel Disease appeared first on News Center .

Subcutaneous delivery of an anti-TNF inhibitor therapy improved remission rates compared to placebo in patients with moderate-to-severe Crohn’s disease and ulcerative colitis who previously completed intravenous anti-TNF therapy, according to clinical trial results published in the journal Gastroenterology. The post Subcutaneous Therapy Improves Inflammatory Bowel Disease Treatment appeared first…

In a new study, researchers found a special diet holds promise for treating people with inflammatory bowel disease, or IBD. The diet is a low-calorie “fasting-mimicking” diet. The study showed the fasting-mimicking diet reduced intestinal inflammation and helped intestinal stem cells grow. With the diet, the researchers reversal of IBD pathology in mice and reduced inflammation in human patients.…

The majority of inflammatory bowel disease (IBD) consists of two related but clinically and histologically distinct conditions, ulcerative colitis and Crohn’s disease. Both conditions are characterized by chronically relapsing inflammation […]