inflammatory-bowel-disease

Mayo Clinic researchers have identified an immune-regulating molecule that may help explain why some patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, do not respond to commonly used therapies.

Many people living with inflammatory bowel disease experience a frustrating problem. Even after their condition is treated and inflammation improves, they continue to have symptoms like stomach pain, bloating, and irregular bowel movements. These symptoms often resemble irritable bowel syndrome and can greatly affect quality of life. Until recently, doctors did not have a clear […] The post Gut i…

Scientists have uncovered an unexpected mechanism by which the gut’s immune system maintains balance, challenging long-standing assumptions about how immune tolerance is regulated. Researchers at Weill Cornell Medicine have uncovered an unexpected mechanism the immune system uses to prevent chronic inflammation in the intestine. The discovery could point to new treatment strategies for inflammato…

IntroductionUlcerative colitis (UC) is one of the predominant forms of inflammatory bowel disease (IBD), and it is a chronic and recurring inflammation of the gastrointestinal trac. However, the therapies are associated with drug resistance and low responsiveness. Ferulic acid (FA) alleviates clinical signs and inflammatory mediators in UC, while the molecular mechanisms of FA regulation on UC re…

Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease, according to a study published in Nature Immunology. The post How a Common Metabolite Worsens Inflammatory Bowel Disease appeared first on News Center .

Subcutaneous delivery of an anti-TNF inhibitor therapy improved remission rates compared to placebo in patients with moderate-to-severe Crohn’s disease and ulcerative colitis who previously completed intravenous anti-TNF therapy, according to clinical trial results published in the journal Gastroenterology. The post Subcutaneous Therapy Improves Inflammatory Bowel Disease Treatment appeared first…

In a new study, researchers found a special diet holds promise for treating people with inflammatory bowel disease, or IBD. The diet is a low-calorie “fasting-mimicking” diet. The study showed the fasting-mimicking diet reduced intestinal inflammation and helped intestinal stem cells grow. With the diet, the researchers reversal of IBD pathology in mice and reduced inflammation in human patients.…

The majority of inflammatory bowel disease (IBD) consists of two related but clinically and histologically distinct conditions, ulcerative colitis and Crohn’s disease. Both conditions are characterized by chronically relapsing inflammation […]