gastroenterology

PurposeRikkunshito, a traditional Japanese herbal medicine, is used to improve gastrointestinal (GI) function. However, its mechanisms of action in irritable bowel syndrome (IBS) remain unclear. This study aimed to investigate the effects of Rikkunshito on colonic pacemaker activity, inflammation, GI hormones, pain-related behaviors, and transient receptor potential (TRP) channel activity in a zy…

Background and objectiveAlthough infliximab (IFX) is endorsed for induction therapy in severe ulcerative colitis (SUC), its therapeutic response remains heterogeneous. We conducted a comprehensive analysis of fecal and mucosal microbiota, coupled with targeted metabolomics, to delineate microbial and metabolic signatures predictive of IFX induction efficacy and to explore mechanistic pathways und…

Patients with hypothyroidism--an underactive thyroid gland--may face significant risk of developing small intestinal bacterial overgrowth (SIBO), according to research led by Cedars-Sinai Health Sciences University investigators.

New study traces network of nerves that disrupt digestion, pointing to potential IBS treatment

If your Gut submission shows Under Review, here is what the BMJ Editor-in-Chief and Associate Editors are doing during each stage and when to follow up.

A study, led by experts at the University of Nottingham, has found that persistent and distressing upper gut symptoms experienced by people with hypermobile Ehlers-Danlos syndrome (hEDS), are not due to structural problems with the gullet (esophagus), as previously assumed.

Many people living with inflammatory bowel disease experience a frustrating problem. Even after their condition is treated and inflammation improves, they continue to have symptoms like stomach pain, bloating, and irregular bowel movements. These symptoms often resemble irritable bowel syndrome and can greatly affect quality of life. Until recently, doctors did not have a clear […] The post Gut i…

Fatty liver disease is becoming one of the fastest-growing health problems in the world. A common type called non-alcoholic fatty liver disease, or NAFLD, now affects around one in four people globally. Many people have never heard of it, and even those who have may not realize they are living with the condition. In the […] The post Scientists discover a possible new treatment for fatty liver dis…

A randomized controlled trial compared the efficacy, tolerability, and safety of different volumes of polyethylene glycol (PEG) regimens for bowel preparation for inpatient colonoscopy.

Gastroenterology and Hepatology overlap on liver, biliary, and GI-disease work, but they reward different first-page framing around GI-wide impact versus liver-disease specialization.

Inflammatory bowel disease, often called IBD, is a long-term condition that causes inflammation in the digestive system. It affects millions of people around the world and can greatly impact daily life. People with IBD often experience ongoing symptoms such as diarrhea, stomach pain, tiredness, and weight loss. Although treatments are available, many patients do not […] The post Study finds a pro…

Avoid desk rejection at CGH by proving immediate GI clinical utility, realistic generalizability, and a sharper clinical relevance case.

Gastroenterology impact factor is 25.1 with a 5-year JIF of 26.9. See rank, trend, and what that number means before submission.

A practical guide to the papers Gastroenterology rejects before review, and what to fix before submitting a GI flagship manuscript.

This Gastroenterology submission guide helps authors decide whether a GI manuscript has enough clinical or translational significance for the AGA flagship.

Inflammatory bowel disease, or IBD, is a condition that affects the digestive system and often lasts for many years. It includes two main types, Crohn’s disease and ulcerative colitis. People with IBD may experience symptoms such as abdominal pain, frequent trips to the bathroom, and ongoing fatigue. While treatments can help control the disease, living […] The post One-third with inflammatory bo…

Diverticulosis is a common condition, especially in older adults. It happens when small pouch-like sacs form in the wall of the large intestine. In many cases, people do not even know they have it because it often causes no symptoms. However, in some situations, these pouches can become inflamed or infected, leading to pain, bleeding, […] The post Widely used blood pressure drug may increase risk…

In her new book You've Been Pooping All Wrong , Dr. Trisha Pasricha shares habits and practices to make your relationship with your solid waste as smooth as possible

Inflammatory bowel disease, often called IBD, is a long-term condition that causes inflammation in the digestive system. It includes diseases such as Crohn’s disease and ulcerative colitis. People with IBD often suffer from abdominal pain, diarrhea, and fatigue. Modern treatments can reduce inflammation and help patients reach what doctors call remission, which means the active […] The post Why g…

New research labelled potential ‘break-through’ for Crohn’s patients - University of Edinburgh-led research has made a significant breakthrough in understanding Crohn’s disease, identifying what drives the development of debilitating scar tissue in the intestines. - The study found that clusters of immune cells within the gut stimulate surrounding cells to produce excessive collagen, leading to t…