gastroenterology

BackgroundUpadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy in inflammatory bowel disease (IBD). However, safety data in real-world Asian populations remain limited. This study aimed to characterize the adverse event (AE) profile of upadacitinib by integrating large-scale pharmacovigilance data with real-world clinical evidence.MethodsWe conducted a dual-source …

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder involving dysregulation of the microbiota-gut-brain (MGB) axis. Acupuncture effectively alleviates IBS symptoms, yet its underlying mechanisms remain incompletely understood. This review synthesizes current evidence to propose a mechanistic framework by which acupuncture treats IBS through MGB axis modulation. We syst…

Aim of the StudyTo observe the efficacy and safety of CQE in rapidly alleviating inflammatory activity in UC.Materials and MethodsCQE extracts were analyzed by UHPLC–Q Exactive Orbitrap–HRMS. This study used a self-controlled design before and after treatment. A total of 114 UC patients were included and treated with traditional rectal enema administration of CQE. Among them, 107 patients complet…

AimsInfliximab (IFX) is widely used for treating Crohn’s disease (CD), but a significant proportion of patients experience primary non-response or loss of response. Early prediction of IFX efficacy is crucial to avoid ineffective treatment, adverse effects, and financial burden. The aim of this study was to develop a stacking model using routine clinical data to predict IFX clinical response.Meth…

IntroductionAspirin-induced gastritis results from reduced prostaglandin synthesis and increased oxidative stress, compromising gastric mucosal integrity. While omeprazole effectively suppresses gastric acid secretion, it does not directly promote mucosal regeneration. Striatin, a bioactive fraction of Channa striata, has anti-inflammatory and regenerative properties and may enhance mucosal heali…

This review synthesizes current evidence on autonomic nervous system (ANS) dysfunction in irritable bowel syndrome (IBS). Patients with IBS often exhibit sympathovagal imbalance–reduced vagal tone with relative sympathetic hyperactivity–which correlates with symptom severity and shows subtype specificity. The ANS orchestrates bidirectional brain–gut communication via interactions with psychosocia…

PurposeRikkunshito, a traditional Japanese herbal medicine, is used to improve gastrointestinal (GI) function. However, its mechanisms of action in irritable bowel syndrome (IBS) remain unclear. This study aimed to investigate the effects of Rikkunshito on colonic pacemaker activity, inflammation, GI hormones, pain-related behaviors, and transient receptor potential (TRP) channel activity in a zy…

Background and objectiveAlthough infliximab (IFX) is endorsed for induction therapy in severe ulcerative colitis (SUC), its therapeutic response remains heterogeneous. We conducted a comprehensive analysis of fecal and mucosal microbiota, coupled with targeted metabolomics, to delineate microbial and metabolic signatures predictive of IFX induction efficacy and to explore mechanistic pathways und…

Patients with hypothyroidism--an underactive thyroid gland--may face significant risk of developing small intestinal bacterial overgrowth (SIBO), according to research led by Cedars-Sinai Health Sciences University investigators.

New study traces network of nerves that disrupt digestion, pointing to potential IBS treatment

If your Gut submission shows Under Review, here is what the BMJ Editor-in-Chief and Associate Editors are doing during each stage and when to follow up.

A study, led by experts at the University of Nottingham, has found that persistent and distressing upper gut symptoms experienced by people with hypermobile Ehlers-Danlos syndrome (hEDS), are not due to structural problems with the gullet (esophagus), as previously assumed.

Many people living with inflammatory bowel disease experience a frustrating problem. Even after their condition is treated and inflammation improves, they continue to have symptoms like stomach pain, bloating, and irregular bowel movements. These symptoms often resemble irritable bowel syndrome and can greatly affect quality of life. Until recently, doctors did not have a clear […] The post Gut i…

Fatty liver disease is becoming one of the fastest-growing health problems in the world. A common type called non-alcoholic fatty liver disease, or NAFLD, now affects around one in four people globally. Many people have never heard of it, and even those who have may not realize they are living with the condition. In the […] The post Scientists discover a possible new treatment for fatty liver dis…

A randomized controlled trial compared the efficacy, tolerability, and safety of different volumes of polyethylene glycol (PEG) regimens for bowel preparation for inpatient colonoscopy.

Gastroenterology and Hepatology overlap on liver, biliary, and GI-disease work, but they reward different first-page framing around GI-wide impact versus liver-disease specialization.

Inflammatory bowel disease, often called IBD, is a long-term condition that causes inflammation in the digestive system. It affects millions of people around the world and can greatly impact daily life. People with IBD often experience ongoing symptoms such as diarrhea, stomach pain, tiredness, and weight loss. Although treatments are available, many patients do not […] The post Study finds a pro…

Avoid desk rejection at CGH by proving immediate GI clinical utility, realistic generalizability, and a sharper clinical relevance case.

Gastroenterology impact factor is 25.1 with a 5-year JIF of 26.9. See rank, trend, and what that number means before submission.

A practical guide to the papers Gastroenterology rejects before review, and what to fix before submitting a GI flagship manuscript.