Zinc supplementation to modulate immune response in non-hodgkin lymphoma: A randomized, double-blind, and placebo-controlled trial

High Grade Non-Hodgkin Lymphoma (NHL) is a malignancy with limited therapeutic alternatives and poor prognosis. Zinc is a known micronutrient that is involved in immune response expression. It was hypothesized that zinc therapy can modulate the immune system following chemotherapy in patients with high grade NHL. This study aimed to explore the effect of zinc supplementation on serum zinc levels and inflammatory profile (NF-κB and Interleukin-12). In a randomized, double-blind, placebo-con