Research Results in Pharmacology

Correction by neuroglutam and succicard of age-associated impairments in accelerated aging in rats with diabetes DOI: https://doi.org/10.18413/rrpharmacology.12.1063Abstract Introduction: The study aimed to investigate the impact of a long-term diabetic state on the development of accelerated aging and to evaluate the efficacy of therapy with metformin, neuroglutam, and succicard in correcting as…

The C3435T genetic polymorphism of the ABCB1 (MDR1) gene as a predictor of antihypertensive efficacy of losartan monotherapy in newly diagnosed arterial hypertension DOI: https://doi.org/10.18413/rrpharmacology.12.1057Abstract Introduction: Losartan, a selective angiotensin II receptor type 1 antagonist, is transported across cell membrane mediated by P-glycoprotein, the product of the ABCB1 (als…

Efficacy of micronized progesterone-based preparations used to prevent placental insufficiency: an experimental study DOI: https://doi.org/10.18413/rrpharmacology.12.1030Abstract Introduction: Progestogen-based drugs have anti-ischemic, antispasmodic, and immunomodulatory effects. Therefore, studying the effect of micronized progesterone (MP) on the inflammatory process in the placenta is of grea…

Evaluation of pharmacological correction of hypoxic-ischemic encephalopathy sequelae using peptide erythropoietin analogs in a mouse model of mild and moderate hypoxic-ischemic encephalopathy during the late remodeling phase DOI: https://doi.org/10.18413/rrpharmacology.12.1075Abstract Introduction: Hypoxic-ischemic encephalopathy (HIE) is an early-life brain injury that remains a leading cause of…

The effect of the azolo-triazine derivative AB-19 on the development of diabetic cardiomyopathy in rats DOI: https://doi.org/10.18413/rrpharmacology.12.1049Abstract Introduction: Cardiovascular diseases, including cardiomyopathies associated with endothelial dysfunction and impaired protein glycation, are the predominant cause of mortality in diabetes mellitus. This article presents data on the i…

Morphometric visualization, analysis, and assessment of atherosclerotic lesions in an apolipoprotein E–deficient mouse model (ApoE−/−) DOI: https://doi.org/10.18413/rrpharmacology.12.1078Abstract Introduction: The improvement of diagnostic methods in atherosclerosis is aimed at accurately determining the stage of the pathological process and eliminating subjective interpretation of data. Implemen…

Evaluation of the neuroprotective effects of synthetic erythropoietin derivatives in a mouse model of mild and moderate hypoxic-ischemic encephalopathy DOI: https://doi.org/10.18413/rrpharmacology.12.1071Abstract Introduction: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal brain injury and long-term neurodevelopmental impairment, and current therapies only partially prevent …

Platform for preclinical screening of neuroprotective strategies: a clinically relevant ICH model and standardized functional test battery DOI: https://doi.org/10.18413/rrpharmacology.12.1043Abstract Introduction: Intracerebral hemorrhage (ICH) is among the most severe forms of stroke. Whereas traditional hemorrhagic stroke models reproduce hemorrhage within the striatum (specifically the putamen…

Study of the biotransformation of a new sydnonimine derivative with predominant cerebral vasodilatory activity DOI: https://doi.org/10.18413/rrpharmacology.11.1042Abstract Introduction: Sydnonimines are a promising group of drugs for development of novel substances with predominant cerebral vasodilatory activity. One of them is experimental compound with laboratory code BBP20233. The mechanism of…

Proteins with the HAEE tetrapeptide motif as potential targets for beta-amyloid DOI: https://doi.org/10.18413/rrpharmacology.11.1046Abstract Introduction: Beta-amyloid (Aβ) is involved in numerous physiological and pathophysiological processes and is one of the key players in the pathogenesis of Alzheimer’s disease. Aβ interacts with the 35-HAEE-38 site of the α4 subunit of the α4β2 nicotinic ace…