Research Results in Pharmacology

Introduction: The problem of cardiorenal syndrome (CRS) in patients with acute coronary syndrome (ACS) and arterial hypertension (AH) is highly relevant. Early diagnosis, based on cystatin C, microalbuminuria, and arterial stiffness, is key for prognosis and therapy selection. Aim: To assess CRS marker dynamics and arterial stiffness in patients with ACS, AH, and chronic kidney disease (CKD) on s…

Introduction: Apoptosis resistance in non-small cell lung cancer is frequently sustained by pro-survival Bcl-2 family proteins such as Mcl-1, motivating the search for new Mcl-1 inhibitors from natural products, including diterpenoids from Rabdosia serra . Materials and Methods: An integrated in silico approach was applied to evaluate R. serra diterpenoids as putative Mcl-1 (PDB: 6QFQ) inhibitors…

Introduction: The inflammatory response to cerebral ischemia plays a crucial role in stroke outcome. This study focuses on the neuroprotective effects of tryptanthrin , a plant alkaloid with anti-inflammatory activity, in the rat model of focal cerebral ischemia (FCI). Materials and Methods: The neurological status of animals was assessed at 4, 24, and 48 hours after FCI (1-hour occlusion of the …

Introduction: Cisplatin is a key drug used for anticancer therapy. However, its use is often accompanied by the development of acute kidney injury. The aim of this study was to develop an optimal model of cisplatin-induced kidney injury in rats and use it to study the nephroprotective properties of polydatin . Materials and Methods. The experiment was performed in 100 male Wistar rats. To test th…

Introduction: Current methods for assessing adherence to combination therapy based on aggregated measures (e.g., PDC, proportion of days covered) poorly capture treatment intensity and sustainability over time. We attempted to describe adherence trajectories for combination therapy using integral metrics. Aim: To develop a set of integral metrics analogous to key pharmacokinetic (PK) parameters –…

Introduction: Metabolic disorders, particularly diabetes mellitus, can lead to the formation of chronic wounds, slowing healing processes. A key factor impeding wound healing is the decreased production of endogenous nitric oxide (NO) due to a hyperglycemic microenvironment. Nitric oxide (NO) is a key signaling molecule produced by three different isoforms of nitric oxide synthase (NOS) – iNOS, e…

Correction by neuroglutam and succicard of age-associated impairments in accelerated aging in rats with diabetes DOI: https://doi.org/10.18413/rrpharmacology.12.1063Abstract Introduction: The study aimed to investigate the impact of a long-term diabetic state on the development of accelerated aging and to evaluate the efficacy of therapy with metformin, neuroglutam, and succicard in correcting as…

The C3435T genetic polymorphism of the ABCB1 (MDR1) gene as a predictor of antihypertensive efficacy of losartan monotherapy in newly diagnosed arterial hypertension DOI: https://doi.org/10.18413/rrpharmacology.12.1057Abstract Introduction: Losartan, a selective angiotensin II receptor type 1 antagonist, is transported across cell membrane mediated by P-glycoprotein, the product of the ABCB1 (als…

Efficacy of micronized progesterone-based preparations used to prevent placental insufficiency: an experimental study DOI: https://doi.org/10.18413/rrpharmacology.12.1030Abstract Introduction: Progestogen-based drugs have anti-ischemic, antispasmodic, and immunomodulatory effects. Therefore, studying the effect of micronized progesterone (MP) on the inflammatory process in the placenta is of grea…

Evaluation of pharmacological correction of hypoxic-ischemic encephalopathy sequelae using peptide erythropoietin analogs in a mouse model of mild and moderate hypoxic-ischemic encephalopathy during the late remodeling phase DOI: https://doi.org/10.18413/rrpharmacology.12.1075Abstract Introduction: Hypoxic-ischemic encephalopathy (HIE) is an early-life brain injury that remains a leading cause of…

The effect of the azolo-triazine derivative AB-19 on the development of diabetic cardiomyopathy in rats DOI: https://doi.org/10.18413/rrpharmacology.12.1049Abstract Introduction: Cardiovascular diseases, including cardiomyopathies associated with endothelial dysfunction and impaired protein glycation, are the predominant cause of mortality in diabetes mellitus. This article presents data on the i…

Morphometric visualization, analysis, and assessment of atherosclerotic lesions in an apolipoprotein E–deficient mouse model (ApoE−/−) DOI: https://doi.org/10.18413/rrpharmacology.12.1078Abstract Introduction: The improvement of diagnostic methods in atherosclerosis is aimed at accurately determining the stage of the pathological process and eliminating subjective interpretation of data. Implemen…

Evaluation of the neuroprotective effects of synthetic erythropoietin derivatives in a mouse model of mild and moderate hypoxic-ischemic encephalopathy DOI: https://doi.org/10.18413/rrpharmacology.12.1071Abstract Introduction: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal brain injury and long-term neurodevelopmental impairment, and current therapies only partially prevent …

Platform for preclinical screening of neuroprotective strategies: a clinically relevant ICH model and standardized functional test battery DOI: https://doi.org/10.18413/rrpharmacology.12.1043Abstract Introduction: Intracerebral hemorrhage (ICH) is among the most severe forms of stroke. Whereas traditional hemorrhagic stroke models reproduce hemorrhage within the striatum (specifically the putamen…

Study of the biotransformation of a new sydnonimine derivative with predominant cerebral vasodilatory activity DOI: https://doi.org/10.18413/rrpharmacology.11.1042Abstract Introduction: Sydnonimines are a promising group of drugs for development of novel substances with predominant cerebral vasodilatory activity. One of them is experimental compound with laboratory code BBP20233. The mechanism of…

Proteins with the HAEE tetrapeptide motif as potential targets for beta-amyloid DOI: https://doi.org/10.18413/rrpharmacology.11.1046Abstract Introduction: Beta-amyloid (Aβ) is involved in numerous physiological and pathophysiological processes and is one of the key players in the pathogenesis of Alzheimer’s disease. Aβ interacts with the 35-HAEE-38 site of the α4 subunit of the α4β2 nicotinic ace…