Introduction: Skin wound healing in cancer patients is a complex issue, influenced by both the tumor process itself and the effects of antitumor therapy. This study assessed the efficacy of various skin wound treatment regimens in mice with transplanted Lewis lung carcinoma (LLC). Materials and Methods: 72 C57BL/6 mice were divided into six groups, including control, topical application of 1% cerium nanoparticles colloidal solution, 5% dexpanthenol spray, 100 mg/kg cyclophosphamide solution, and