Introduction: Skin wound healing in cancer patients is a complex issue, influenced by both the tumor process itself and the effects of antitumor therapy. This study assessed the efficacy of various skin wound treatment regimens in mice with transplanted Lewis lung carcinoma (LLC). Materials and Methods: 72 C57BL/6 mice were divided into six groups, including control, topical application of 1% cerium nanoparticles colloidal solution, 5% dexpanthenol spray, 100 mg/kg cyclophosphamide solution, and a combination of these. Results and Discussion: It was found that topical application of cerium nanoparticles without chemotherapeutic treatment significantly shortened the time of wound regeneration to 16.5±1.0 days (p≤0.05) and reduces a postoperative scar (6±0.3 mm², p≤ 0.0001). Systemic chemotherapy treatment increased the healing time (22.5±1.0 days) and scar area (55.0±0.7 mm²), while reducing a tumor volume by 34% comparing to such in the control group. Combination therapy by dexpanthenol and cyclophosphamide promoted an antitumor effect and accelerated a tissue repair (16.3 ± 0.8 days). At the same time, local application of cerium nanoparticles did not alter regeneration (21.5 ± 1.0 days); however, the scar area was smaller (10.0 ± 0.7 mm²). Histological analysis revealed that the highest vascular density and maturity of granulation tissue in a wound were observed when treated cerium nanoparticles, while epithelial cell proliferation was reduced by cyclophosphamide . Conclusion: The obtained data indicate the potential of topical application daily for 7 days of 1% nanocerium to accelerate wound regeneration in cancer patients without chemotherapy, and 5% dexpanthenol to accelerate skin regeneration in cancer patients receiving chemotherapy.