Effect of a new acetylaminohexanic acid derivative on wound healing and wound blood supply in mice with a mutation in the Agouti gene with inhibition of NOS isoform expression

Introduction: Metabolic disorders, particularly diabetes mellitus, can lead to the formation of chronic wounds, slowing healing processes. A key factor impeding wound healing is the decreased production of endogenous nitric oxide (NO) due to a hyperglycemic microenvironment. Nitric oxide (NO) is a key signaling molecule produced by three different isoforms of nitric oxide synthase (NOS) – iNOS, eNOS, and nNOS – which regulate all phases of skin wound healing. Materials and Methods: The effect of