neuroprotection

Introduction: The inflammatory response to cerebral ischemia plays a crucial role in stroke outcome. This study focuses on the neuroprotective effects of tryptanthrin , a plant alkaloid with anti-inflammatory activity, in the rat model of focal cerebral ischemia (FCI). Materials and Methods: The neurological status of animals was assessed at 4, 24, and 48 hours after FCI (1-hour occlusion of the …

Acta Pharmacologica Sinica, Published online: 20 May 2026; doi:10.1038/s41401-026-01813-w Targeting the mitochondrial thermogenesis pathway for neuroprotection in neonatal hypoxic-ischemic encephalopathy by curcumin

Researchers in the WashU Medicine John F. Hardesty, MD, Department of Ophthalmology & Visual Sciences have discovered key neuroprotective genes that could lead to the development of gene therapies to treat retinitis pigmentosa, an inherited form of retinal degeneration that causes blindness. The findings, published in Neuron April 9, point to new therapeutic strategies to maintain retinal hea…

ObjectiveThis study aimed to assess the efficacy of ligustrazine in treating cerebral ischemia-reperfusion (I/R) injury and construct a preclinical evidence framework by meta-analysis and machine learning.MethodsA systematic search was conducted for preclinical studies published in PubMed, Embase, Web of Science, and the Cochrane Library up to June 25, 2024. The inclusion criteria encompassed pre…

BackgroundLycium barbarum glycopeptide (LbGp) has been reported to exert neuroprotective effects, yet its role in chronic ocular hypertension (COH) and the underlying mechanisms remain unclear. This study investigated whether LbGp protects against COH-induced retinal damage by inhibiting pyroptosis.MethodsA COH rat model was established, and the animals were randomly assigned to model, LbGp, VX-7…

Evaluation of the neuroprotective effects of synthetic erythropoietin derivatives in a mouse model of mild and moderate hypoxic-ischemic encephalopathy DOI: https://doi.org/10.18413/rrpharmacology.12.1071Abstract Introduction: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal brain injury and long-term neurodevelopmental impairment, and current therapies only partially prevent …

Our Bridging the Gap series makes a return! For each post, we interview women in neuroscience about health inequalities and the research aiming to close these gaps. In this article, we focus on neuroprotection in premature babies, and the communication tool that Maria Pureza Laudiano-Dray and her team are implementing to protect preterm infants’ developing brains during the earliest and most vuln…

Since Ed Hall and colleagues first discovered that female gerbils were relatively protected from global cerebral ischemia, compared with their male counterparts, in the early 1990s (Hall et al., 1991), gender differences […]