neuroinflammation

Chronic pain affects hundreds of millions worldwide, yet current treatments—from NSAIDs to opioids—fall short and bring unwanted side effects. Neuroinflammation drives bidirectional glial-neuronal communication, a core mechanism underlying central sensitization in chronic pain, with chemokines serving as key mediators. Most studies to date have zeroed in on isolated pathways or specific anatomica…

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation Ralvenius, William T; Mungenast, Alison E; Woolf, Hannah; Huston, Margaret M; Gillingham, Tyler Z; Godin, Stephen K; Penney, Jay; Cam, Hugh P; Gao, Fan; Fernandez, Celia G; Czako, Barbara; Lightfoot, Yaima; Ray, William J; Beckmann, Adrian; Goate, Alison M; Marcora, Edoardo; Romero-Molina, Carmen; …

IntroductionExcessive activation of the adenosine A2A receptor (A2AR) contributes to chronic neuroinflammation, in part through spatial coupling with the adenosine-generating enzyme CD73, which enables localized adenosine signaling. Coordinated regulation of Nt5e and Adora2a across neuropathological conditions supports dual targeting of the CD73/A2AR axis to constrain maladaptive inflammatory sig…

Sepsis-associated encephalopathy (SAE) is a devastating neurological complication of sepsis, leading to diffuse brain dysfunction, long-term cognitive deficits, and increased mortality. Its pathogenesis is complex, with mitochondrial dysfunction and neuroinflammation emerging as central, interconnected drivers. This review systematically elucidates the pathogenic crosstalk between these two proce…

BackgroundExposure to high-altitude hypoxia is associated with an increased risk of impaired brain structure and function, with oxidative stress and neuroinflammation widely recognized as key mechanisms involved. In this context, hyperbaric oxygen therapy is considered a potential intervention; however, the mechanism by which it affects cerebral function changes caused by high-altitude exposure r…

The study investigates the neuroprotective potential of paeoniflorin (PNN) in mitigating the multifaceted pathology of multiple sclerosis (MS) in an ethidium bromide-induced (EBRO) rat model. A comprehensive approach utilizing in silico, in-vitro, and in-vivo methodologies reveals that PNN targets key molecular pathways implicated in MS, including the GDNF/GFRA1/RET/AKT/ERK1/2/GSK3-Beta signaling…

A recent review of animal studies suggests that caffeine blocks specific cellular receptors to reduce neuroinflammation. This immune-calming effect may help alleviate behavioral symptoms associated with mood disorders.

Authors: Dr. Salinee Jantrapirom and Dr. Luca Lo Piccolo Affiliations: Faculty of Medicine, Chiang Mai University, Thailand Key themes: Growth of Thai neuroscience • Cellular and synaptic foundations • Neuroinflammation and oxidative stress • Translational research • Genomics Thailand and T-REx • Model-organism platforms (Drosophila and zebrafish) • Regional research capacity building   Reflectio…

Authors: Prof. Bamidele V. Owoyele Affiliations: Department of Physiology, University of Ilorin, Nigeria Key themes: Neuroscience capacity building in Africa • Alternative animal models in neuroscience • Invertebrate models (Drosophila, C. elegans)  • Neuroinflammation • Experimental models of hydrocephalus • Neuropathology • Youth engagement and neuroscience education • African neuroscience netw…

Authors: Dr. Sophie Layé & Dr. Etienne Coutureau Affiliations: Université de Bordeaux Key themes: Brain–immune interactions • Neuroinflammation • Glial biology • Neurodegenerative diseases • Motivation and decision-making circuits • Functional neurosurgery • Translational neuroscience • Brain–machine interfaces Reflection #2 Over the past five decades, neuroscience in France has flourished throug…

New insights into immune cells in the context of neurodegeneration Bonn/Germany, February 4, 2025. Scientists from DZNE, University Hospital Bonn (UKB) and the University of Bonn provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer’s disease. Their findings, based on studies in cell culture, mice and tissue samples from patients, may contr…

Research underscores involvement of the brain’s immune system Munich/Germany, December 6, 2024. In the journal Science Translational Medicine, scientists from DZNE and LMU Hospital report on new insights into the mechanisms of “Niemann-Pick type C” (NPC), a rare neurodegenerative disease associated with dementia that can manifest as early as childhood. Their findings, based on studies in mice, ce…

Northwestern Medicine investigators have identified how a calcium channel in the nervous system contributes to brain inflammation, according to a study published in Nature Communications. The post Ion Channel Linked to Brain Inflammation Identified appeared first on News Center .

Northwestern Medicine investigators have discovered that specific calcium channels help regulate sex differences in the functioning of immune cells for neuroinflammation and overall neuropathic pain. The post Calcium Channels Regulate Neuroinflammation and Neuropathic Pain appeared first on News Center .