depression

BackgroundPrenatal stress (PS) is a major risk factor for depression later in life, yet the cellular mechanisms linking early-life adversity to long-term affective vulnerability remain incompletely understood. Neuropeptide receptors have emerged as important modulators of stress-related psychopathology, but their roles in mitochondrial regulation within limbic circuits remain largely unexplored.M…

IntroductionExisting data indicate that an increasing number of adolescents are becoming addicted to online games, while the prevalence of depressive symptoms within this demographic is also on the rise. Depression is a primary comorbidity associated with game addiction, but the influencing factors and mechanisms remain unclear. This study aims to explore the mediating role of game addiction in t…

Depressive disorders are highly heterogeneous syndromes characterized not only by depressed mood but also by cognitive impairment, sleep–circadian rhythm disturbances, altered appetite, somatic discomfort, and metabolic or gastrointestinal comorbidities. In recent years, the microbiota–gut–brain axis (MGBA) has been increasingly recognized as an integrative biological framework linking abnormalit…

BackgroundDepressive symptoms are common among patients with cancer and can substantially impair quality of life, treatment adherence and overall well-being. Although exercise has been increasingly recognised as a promising non-pharmacological strategy for alleviating depression in oncology settings, existing evidence has focused predominantly on breast cancer, with limited attention to lung and …

BackgroundNon-suicidal self-injury (NSSI) is highly prevalent in adolescents with major depressive disorder (MDD); however, its underlying pathophysiological mechanisms remain incompletely elucidated. Emerging evidence suggests a potential association between antioxidant markers, thyroid function parameters, and the occurrence of NSSI, although research in this domain remains limited. Accordingly…

BackgroundLarge-scale earthquakes are associated with high and persistent rates of post-traumatic stress disorder (PTSD), depression, and anxiety. Although Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT) are both guideline-recommended treatments for PTSD, direct randomized comparisons—particularly in post-disaster settings and via remote delivery—remain…

BackgroundTinnitus is closely associated with psychological factors including anxiety, depression, and sleep disturbances. However, how these variables interact to influence tinnitus severity remains poorly understood, warranting further exploration.MethodsThis retrospective study analyzed data from 285 patients with tinnitus, utilizing the Tinnitus Handicap Inventory (THI), Self-Rating Depressio…

ObjectiveTo investigate the current status of depression in women in the second and third trimesters of pregnancy, analyze the factors associated with depressive symptoms during this period,and construct an artificial neural network-based risk prediction model for depressive symptoms, with the aim of providing evidence for early screening, risk identification, and targeted intervention.MethodsA c…

BackgroundMajor Depressive Disorder (MDD) causes global disability and economic burden. Standard treatments often yield incomplete recovery with impaired health-related quality of life (HR-QoL). This meta-analysis evaluates exercise interventions’ effects on HR-QoL in adults with clinically diagnosed MDD.MethodsFollowing PRISMA 2020 guidelines, randomized controlled trials (RCTs) of adults (≥18 y…

BackgroundThe Somatic Symptom Scale-8 (SSS-8) is a brief self-report instrument assessing somatic symptom burden derived from the PHQ-15. The aims of the present study were providing updated population norms for Germany based on a new representative sample and enabling a direct comparison with the original 2012 normative sample. In addition, the study aimed to examine the psychometric properties …

A new study suggests that diets rich in fiber, folate, magnesium, and selenium are linked to a lower risk of depression. Researchers recommend getting these nutrients from whole foods rather than supplements to support mental wellbeing.

Older adults in Colorado were drawn to edible cannabis mainly to manage sleep problems, pain, anxiety, or depression, often after concerns about conventional medicines or limited relief from other treatments. Most participants preferred THC-CBD combination products, but they remained uncertain about dosing, impairment, effectiveness, and how to choose the right cannabinoid ratio.

A new pilot study suggests that taking small, sub-perceptual doses of LSD could temporarily boost feelings of creativity and social connection in individuals with major depression. However, researchers caution that placebo-controlled trials are still needed.

Gemma Correll has suffered from anxiety and depression disorders since childhood, and at 16 she discovered a magical elixir that promised to make her feel better. In this extract from her new book, she shows how that promise was broken In 2018, I was in my 30s and living in Oakland, California, having moved there from the UK in 2015. I had always struggled with anxiety and panic attacks , but I w…

BackgroundPostherpetic neuralgia (PHN) is often accompanied by depression, creating a vicious cycle that exacerbates symptoms and contributes to suboptimal treatment outcomes, even with interventional therapies. Repetitive transcranial magnetic stimulation (rTMS) has demonstrated potential in alleviating both pain and mood disturbances. However, its efficacy in enhancing prognosis when used along…

Insightful Psychiatry offers meticulous, personalized Depression Medication Management in Maryland, focusing on achieving full remission through a structured, evidence-based process. This involves a comprehensive evaluation, careful “start low, go slow” dose optimization with regular symptom monitoring, and proactive management of potential side effects. The expert care considers Maryland-specifi…

Depression Medication Management in Washington is a continuous, evidence-based partnership focused on the safe selection, monitoring, and precise optimization of antidepressant medications for long-term stability. The process includes a comprehensive evaluation of symptoms and co-existing conditions (like anxiety or ADHD), careful dosage adjustments based on personalized brain chemistry, and spec…

Written by Joao L. de Quevedo, MD, PhD Depression is relentless. For many, it’s a shadow that refuses to lift—even with medication, therapy, or even electroconvulsive therapy. However, a pioneering study from the UTHealth Houston Center for Interventional Psychiatry has been... The post Long-Term Success with Deep Brain Stimulation for Treatment-Resistant Depression appeared first on Louis A. Fai…

Written by Joao L. de Quevedo, MD, PhD Introduction Major depressive disorder (MDD) affects millions worldwide, and for nearly half of these individuals, standard treatments such as medication and psychotherapy are insufficient. This condition, known as treatment-resistant depression (TRD), has prompted... The post Pragmatic Accelerated Theta-Burst Stimulation Shows Promise for Treatment-Resistan…

Written by Joao L. de Quevedo, MD, PhD Introduction For individuals with treatment-resistant depression (TRD)—those who have not found relief with traditional antidepressants—the search for effective treatment options can be frustrating and exhausting. A recent randomized controlled trial by Dalhuisen et... The post rTMS vs. Antidepressants: A New Path for Treatment-Resistant Depression appeared …