depression

A systematic review of animal research suggests that caffeine can reduce anxiety and depressive-like behaviors by acting as a brake on the brain's immune system and lowering neuroinflammation.

For the past decade, depression has been linked to a shrunken hippocampus, which has a vital role in memory. But a large study using up-to-date scanning techniques suggests this may not be the case

BackgroundTreatment resistant depression (TRD) is a burdensome condition with a severe impact on patients’ everyday lives. Therapeutics have improved in the last decade, however, outcomes remain poor. Real-world characterization has become increasingly important to accurately depict the clinical setting. ResisToday was an observational, prospective, multicenter study that aimed to increase availa…

A new neuroimaging study suggests that adults with depression who experienced childhood trauma tend to have lower levels of myelin in specific brain regions. This indicates a potential biological link between early adversity and depressive symptoms.

Electroencephalography (EEG)-based depression classification requires interpretable machine-learning approaches and validation strategies that avoid subject-level information leakage. This single-center pilot study developed and internally evaluated a marker-based interpretable machine-learning framework using eight-channel resting-state EEG. After quality control, 48 participants were included, …

BackgroundAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists into adulthood, negatively impacting occupational, social, and economic outcomes. The Adult ADHD Investigator Symptom Rating Scale (AISRS) is a clinician-administered tool designed to evaluate ADHD symptom severity and treatment response. However, a validated Japanese version is not avai…

Depression affects hundreds of millions of people worldwide and is expected to become an even greater public health challenge over the coming decades. While many patients improve with antidepressants, counselling, or a combination of both, others continue to struggle despite receiving appropriate treatment. Scientists are therefore developing new therapies that target the brain directly rather [……

Major depressive disorder (MDD) is a severe, clinical type of depression, a more broadly defined...

Depression, also called major depressive disorder (MDD), is one of the most common mental health conditions in the world. People with depression often experience long-lasting sadness, lose interest in activities they once enjoyed, have trouble sleeping or eating, feel tired, and find it difficult to think clearly or concentrate. Although depression affects millions of people, […] The post Scienti…

A nationwide Icelandic study found that 6.9% of women aged 18-69 reported trauma-associated sleep disturbances in the past month. These symptoms were most common after sexual or physical violence, recent or repeated trauma, and were strongly linked to PTSD, anxiety, depression, and general sleep problems.

Depression is one of the most common and serious mental health conditions in the world. It affects hundreds of millions of people and can change nearly every part of daily life. People with depression often feel sad, empty, or hopeless for long periods of time. Many lose interest in activities they once enjoyed. Some struggle […] The post This Walking Style May Reduce Depression in 5 Weeks appear…