clinical-research

Researchers at UT Southwestern Medical Center studying Parkinson's disease have discovered a previously unrecognized sequence of abnormal activity across multiple regions of the brain, providing a new level of understanding that could improve treatment options.

Jordyn Bugarin had made up her mind. After a brutal experience with an experimental drug at another institution -- one that left her skin peeling and her mental health in free fall -- the 22-year-old was finished with clinical research. R..

Jordyn Bugarin had made up her mind. After a brutal experience with an experimental drug at another institution -- one that left her skin peeling and her mental health in free fall -- the 22-year-old was finished with clinical research. R..

Medical imaging foundation models are reshaping how artificial intelligence (AI) may interpret scans, combine clinical information, and support multiple tasks from a shared computational base. Rather than training a separate model for every disease or imaging problem, the approach uses large-scale pre-training to encode reusable knowledge into generalizable representations, which can then be adap…

BackgroundTreatment resistant depression (TRD) is a burdensome condition with a severe impact on patients’ everyday lives. Therapeutics have improved in the last decade, however, outcomes remain poor. Real-world characterization has become increasingly important to accurately depict the clinical setting. ResisToday was an observational, prospective, multicenter study that aimed to increase availa…

U-M researchers led the largest U.S. trial to determine effective cooling durations to preserve brain function in patients with out-of-hospital cardiac arrests

ObjectiveTo evaluate the synergistic effect of serum Galectin-3 (Gal-3) and Th1/Th2 level-related cytokines, and its association with severe anxiety and depression symptoms in patients with chronic obstructive pulmonary disease (COPD), aiming to provide potential indicators for clinical stratified assessment.MethodsThis study was a cross-sectional study. A total of 115 patients with COPD who were…

BackgroundVisual hallucinations (VH) are distressing and clinically relevant after cardiac surgery. C-reactive protein–albumin–lymphocyte (CALLY) index reflects systemic inflammation, nutrition, and immune competence. This study evaluated whether preoperative CALLY predicts 7-day postoperative VH.MethodsIn a prospective multicenter cohort (10 cardiac centers; September 2022 to May 2025), adults u…

Scientific Data, Published online: 17 July 2026; doi:10.1038/s41597-026-07872-2 Clinical features and intraocular lens material properties for posterior capsule opacification risk prediction

BackgroundCorynebacterium striatum is increasingly recognized as a multidrug-resistant (MDR) opportunistic pathogen, yet its role in psychiatric hospitals remains poorly characterized. Differentiating colonization from true infection in this setting is clinically challenging.MethodsThirty C. striatum isolates were obtained from psychiatric inpatients with prolonged hospitalization. Antimicrobial …

IntroductionClinical outcomes in individuals with at-risk mental states (ARMS) are heterogeneous and extend beyond the simple dichotomy between transition and non-transition to psychosis. While previous studies have primarily focused on predicting the transition to psychosis, few have systematically examined multiple outcome stages, including remission and persistent subthreshold symptoms, using …

HonorHealth Research Institute is looking to become the first research facility in the nation to begin a new clinical trial that aims to modify the lining of the digestive tract with the use of steam energy to control type II diabetes without the use of drugs.

NGx brings together forward-thinking minds at the intersection of nutrition, genetics, and health to explore where science is going next—and how it’s already shaping the way we understand and apply precision nutrition. This is more than a conference; it is a chance to engage directly with the research, the people behind it, and the ideas that are redefining the field.

IntroductionDrug-induced QT interval prolongation is a well-recognized safety concern in hospitalized patients. Clinical decision support systems (CDSS) generate alerts to identify high-risk drug combinations, but their impact on clinical management remains uncertain.MethodsThis study evaluated clinical responses from prescribing clinicians to QT prolongation alerts, focusing on electrocardiogram…

Initial data from the Esprit BTK post-approval study, presented at the 2026 Charing Cross (CX) Symposium (21–23 April, London, UK), revealed “promising” 30-day results, according to an Abbott press release. The data showed the company’s Esprit BTK everolimus-eluting resorbable scaffold system is a safe and effective approach in patients with very challenging chronic limb-threatening ischaemia […]…

In clinical research, safety documentation plays a critical role in protecting participants and ensuring regulatory transparency. Among the many documents generated during a study, safety narratives and Clinical Study Report (CSR) narratives are often discussed together—and sometimes interchangeably, which can cause confusion. Despite sharing similar terminology, these two narrative types serve d…

Newswise — Understanding pediatric clinical trials is the first step toward deciding if your child should join one. Is participation in clinical research right for your family? Children's Hospital Los Angeles shares the answers to parents' frequently asked questions. What is a clinical trial? Clinical trials are research studies that test medications, therapies, devices, and procedures to see if …

Join us as we present the findings of AMRC's 2025 industry consultation on quality in clinical research and outline the steps the association will take to define and recognise quality in practice.

🧬 Behind the Scenes: How Our Obesity Trials Are Shaping the Future of Weight Management Obesity is a complex condition affecting millions worldwide — and at [Your Company Name], we’re committed to advancing solutions through science, compassion, and innovation. Our clinical trials are more than data collection; they’re a gateway to better health, deeper understanding, ... Read more The post 🧬 Beh…