Targeting m 6 A writer METTL3 with engineered nanovesicles reduces neuroinflammation in vitro and in vivo

Nature Communications, Published online: 08 August 2026; doi:10.1038/s41467-026-75862-4 Strategies to modulate neuroinflammation have broad therapeutic potential. Here, the authors develop siMETTL3-hNVs, nanovesicles carrying siRNA targeting METTL3, and show they can reduce neuroinflammation in vitro and in vivo.