Disease-associated RNA and protein signatures in iPSC-derived microglia model of Alzheimer’s disease
Xiaoyong Bao
20d ago
alzheimer-s-diseasemedicinemicrogliamulti-omicsneuroscience
IntroductionMicroglia, the resident immune cells of the central nervous system, play a critical role in maintaining neural homeostasis and regulating inflammatory responses in the brain. Increasing evidence suggests that microglial dysfunction contributes to the progression of neurodegenerative diseases, including Alzheimer’s disease (AD). However, the molecular mechanisms underlying these altera…