alzheimer-s-disease

BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta plaques and neurofibrillary tangles. Dysfunctional cellular clearance mechanisms, particularly autophagy-lysosomal pathways, and reactive astrocytosis are prominent pathological features, yet their interrelationship remains poorly defined.ObjectiveThis study aimed to decipher a novel co-ex…

Alzheimer’s disease (AD) is usually framed as a proteinopathy and network disorder, but this view may be incomplete. We propose a mechanobiological hypothesis in which synaptic micromechanics, regional brain softening, vascular pulsatility, and glymphatic transport are parts of a coupled fluid–solid system whose failure contributes to AD progression. In this framework, early synaptic and glial me…

Tiny lab-grown brain models and the particles they release may reveal hidden differences among Alzheimer’s patients. Personalized treatment remains one of the biggest challenges in Alzheimer’s disease. Two patients can receive the same medication for symptoms such as depression, anxiety, or agitation and experience very different outcomes, leaving doctors with few ways to predict who [...]

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04409-3 We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amylo…

Alzheimer’s disease is the most common cause of dementia, affecting millions of people around the world. It slowly destroys memory, thinking skills, and the ability to carry out everyday activities. Despite decades of research, scientists are still trying to understand exactly why the disease develops and how it progresses over time. One area receiving increasing […] The post A Hidden Brain Switc…

IntroductionMicroglia, the resident immune cells of the central nervous system, play a critical role in maintaining neural homeostasis and regulating inflammatory responses in the brain. Increasing evidence suggests that microglial dysfunction contributes to the progression of neurodegenerative diseases, including Alzheimer’s disease (AD). However, the molecular mechanisms underlying these altera…

Obesity may worsen Alzheimer’s disease through fat molecules that send harmful signals to the brain, but targeting those molecules could offer a new path for intervention. Alzheimer’s disease is often viewed as a disorder that begins and ends in the brain. But growing evidence suggests the disease may also be shaped by what happens throughout [...]

Consumption of eggs is associated with a lower risk of being diagnosed with Alzheimer's Disease for those 65 years and older, according to researchers at Loma Linda University Health. Eating one egg per day for at least five days a week reduces risk of Alzheimer’s by up to 27%, researchers found. “C...

Alzheimer’s disease is usually known as a brain condition. Most people think of memory loss, confusion, and changes in thinking as the main signs. Doctors have long believed that the disease begins in the brain and then slowly affects other parts of the body. But a new study suggests that this may not always be […] The post Could Alzheimer’s disease start outside the brain? appeared first on Know…

For many people, Alzheimer’s disease seems to appear suddenly, with memory loss and confusion becoming clear only later in life. However, new research suggests that the process may begin much earlier, long before any symptoms are noticed. Scientists at the Gladstone Institutes have found new evidence that changes in the brain can start early in […] The post Scientists discover an early cause of A…

Scientists have developed a new class of microscopic antibody fragments capable of functioning inside human cells, overcoming a long-standing limitation in biomedical science. New treatments for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and motor neuron disease (MND) may emerge from microscopic medicines developed by researchers at the University of Essex. An international team…

Researchers have found that consuming arginine reduces amyloid beta accumulation in mice and fruit flies. This common amino acid improved behavioral symptoms, pointing to a potential new strategy for managing Alzheimer's pathology.

Van Andel Institute - Van Andel Institute transforms human health through groundbreaking biomedical research and cutting-edge science education.