alzheimer-s-disease

Tiny lab-grown brain models and the particles they release may reveal hidden differences among Alzheimer’s patients. Personalized treatment remains one of the biggest challenges in Alzheimer’s disease. Two patients can receive the same medication for symptoms such as depression, anxiety, or agitation and experience very different outcomes, leaving doctors with few ways to predict who [...]

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04409-3 We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amylo…

Alzheimer’s disease is the most common cause of dementia, affecting millions of people around the world. It slowly destroys memory, thinking skills, and the ability to carry out everyday activities. Despite decades of research, scientists are still trying to understand exactly why the disease develops and how it progresses over time. One area receiving increasing […] The post A Hidden Brain Switc…

IntroductionMicroglia, the resident immune cells of the central nervous system, play a critical role in maintaining neural homeostasis and regulating inflammatory responses in the brain. Increasing evidence suggests that microglial dysfunction contributes to the progression of neurodegenerative diseases, including Alzheimer’s disease (AD). However, the molecular mechanisms underlying these altera…

BackgroundConvolutional neural networks (CNNs) have achieved remarkable success in medical image analysis, including Alzheimer’s disease (AD) classification. However, conventional convolution operations rely on fixed sampling patterns, and most existing attention mechanisms primarily focus on feature responses while neglecting spatial sampling geometry, limiting their ability to capture structura…

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most prevalent neurodegenerative disorders (ND) globally, disproportionately affecting the elderly population. Traditionally viewed as distinct diseases, AD is defined by symptoms of cognitive impairment and dementia with amyloid-β and tau protein pathologies, while PD is defined by motor symptoms and eventual dementia with α-synuc…

Obesity may worsen Alzheimer’s disease through fat molecules that send harmful signals to the brain, but targeting those molecules could offer a new path for intervention. Alzheimer’s disease is often viewed as a disorder that begins and ends in the brain. But growing evidence suggests the disease may also be shaped by what happens throughout [...]

Consumption of eggs is associated with a lower risk of being diagnosed with Alzheimer's Disease for those 65 years and older, according to researchers at Loma Linda University Health. Eating one egg per day for at least five days a week reduces risk of Alzheimer’s by up to 27%, researchers found. “C...

Alzheimer’s disease is usually known as a brain condition. Most people think of memory loss, confusion, and changes in thinking as the main signs. Doctors have long believed that the disease begins in the brain and then slowly affects other parts of the body. But a new study suggests that this may not always be […] The post Could Alzheimer’s disease start outside the brain? appeared first on Know…

For many people, Alzheimer’s disease seems to appear suddenly, with memory loss and confusion becoming clear only later in life. However, new research suggests that the process may begin much earlier, long before any symptoms are noticed. Scientists at the Gladstone Institutes have found new evidence that changes in the brain can start early in […] The post Scientists discover an early cause of A…

Scientists have developed a new class of microscopic antibody fragments capable of functioning inside human cells, overcoming a long-standing limitation in biomedical science. New treatments for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and motor neuron disease (MND) may emerge from microscopic medicines developed by researchers at the University of Essex. An international team…

Researchers have found that consuming arginine reduces amyloid beta accumulation in mice and fruit flies. This common amino acid improved behavioral symptoms, pointing to a potential new strategy for managing Alzheimer's pathology.

Scientists are using focused ultrasound to deliver a neuroprotective and anti-inflammatory protein to the brain in a model of Alzheimer’s disease.

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