Acta Pharmacologica Sinica

Acta Pharmacologica Sinica, Published online: 21 August 2026; doi:10.1038/s41401-026-01880-z Targeting CYBA inhibits hepatic metastasis of pancreatic cancer through AKT/MLC2 pathway

Acta Pharmacologica Sinica, Published online: 21 August 2026; doi:10.1038/s41401-026-01917-3 AKT (Ser473) suppression mediates ceritinib cardiotoxicity through autophagic flux impairment and mitochondrial injury

Acta Pharmacologica Sinica, Published online: 21 August 2026; doi:10.1038/s41401-026-01900-y RNF6 activates the AKT/mTOR signaling pathway by inhibiting PTEN via K27-linked polyubiquitination in myeloma

Acta Pharmacologica Sinica, Published online: 19 August 2026; doi:10.1038/s41401-026-01909-3 A prelimbic cortex-lateral hypothalamus circuit regulates acquisition of alprazolam-induced conditioned place preference in male mice

Acta Pharmacologica Sinica, Published online: 18 August 2026; doi:10.1038/s41401-026-01906-6 SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01902-w Direct β-arrestin engagement by the non-canonical WNT receptor FZD6 via a shallow binding pocket

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01896-5 Oxyberberine-nanoparticle attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating gut microbiota through suppressing CXCL10/CXCR3 pathway

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01894-7 PDE4D-CXCL13 axis in gland epithelial cells promotes B cell infiltration in primary Sjögren’s syndrome

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01899-2 Tumor-driven arginine depletion induces T-cell metabolism reprogramming to suppress atherosclerosis in colorectal cancer

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01903-9 Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01907-5 BDKRB2 upregulation by dystrophic microglia drives pain hypersensitivity in aged mice

Acta Pharmacologica Sinica, Published online: 12 August 2026; doi:10.1038/s41401-026-01883-w Hyper-O-GlcNAcylation destabilizes ARC to unleash NLRP3-mediated pyroptosis in diabetic cardiomyopathy

Acta Pharmacologica Sinica, Published online: 10 August 2026; doi:10.1038/s41401-026-01904-8 Protein–protein interaction-mediated signaling networks in ischemic stroke: from molecular mechanisms to therapeutic strategies

Acta Pharmacologica Sinica, Published online: 10 August 2026; doi:10.1038/s41401-026-01908-4 Emerging roles of mitophagy in liver fibrosis: Implications for therapy

Acta Pharmacologica Sinica, Published online: 06 August 2026; doi:10.1038/s41401-026-01882-x Gut microbiota modulation of gastrointestinal cancers: from dysbiosis signatures to therapeutic interventions

Acta Pharmacologica Sinica, Published online: 05 August 2026; doi:10.1038/s41401-026-01885-8 Smoothened signaling in microglia: canonical or not, and does it promote or limit inflammation?

Acta Pharmacologica Sinica, Published online: 04 August 2026; doi:10.1038/s41401-026-01898-3 Ginkgo biloba L. in preventing cardiovascular disease: pharmacological effects, mechanism of action, and therapeutic potential

Acta Pharmacologica Sinica, Published online: 04 August 2026; doi:10.1038/s41401-026-01897-4 Targeting FOSL1-KCa3.1 inhibits ferroptosis and cartilage destruction by suppressing mitochondrial hyperfusion

Acta Pharmacologica Sinica, Published online: 04 August 2026; doi:10.1038/s41401-026-01881-y Secreted chimeric proteins as a strategy to correct SOX17 deficiency and attenuate the malignant phenotype of cholangiocarcinoma cells: a proof-of-concept study

Acta Pharmacologica Sinica, Published online: 04 August 2026; doi:10.1038/s41401-026-01893-8 STK40 inhibits profibrotic Arg1 + macrophage differentiation and renal fibrosis by regulating poly-ubiquitination of STAT3