Acta Pharmacologica Sinica

Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions

Yan Zhao

10h ago

Acta Pharmacologica Sinica, Published online: 04 May 2026; doi:10.1038/s41401-026-01794-w Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions

diagnosticsmaterialsmedicinenanomaterialstherapeutics

Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling

Xiao-chun Yang

5d ago

Acta Pharmacologica Sinica, Published online: 30 April 2026; doi:10.1038/s41401-026-01807-8 Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling

biochemistrybiologycell-biologymedicineoncology

Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5–VEGF signaling axis in macrophages to alleviate myocardial infarction

Jian-ge Zhang

6d ago

Acta Pharmacologica Sinica, Published online: 29 April 2026; doi:10.1038/s41401-026-01799-5 Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5–VEGF signaling axis in macrophages to alleviate myocardial infarction

angiogenesiscardiologymedicinepharmacology

Targeting endoplasmic reticulum stress and YAP/TAZ-SMAD1/5 signaling to ameliorate endothelial dysfunction in diabetes

Wai San Cheang

7d ago

Acta Pharmacologica Sinica, Published online: 28 April 2026; doi:10.1038/s41401-026-01802-z Targeting endoplasmic reticulum stress and YAP/TAZ-SMAD1/5 signaling to ameliorate endothelial dysfunction in diabetes

biologycell-biologydiabetesmedicinepharmacology

Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury

You Shang

8d ago

Acta Pharmacologica Sinica, Published online: 27 April 2026; doi:10.1038/s41401-026-01804-x Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury

medicineneurodegenerationpharmacology

Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke

Hai-tao Wang

8d ago

Acta Pharmacologica Sinica, Published online: 27 April 2026; doi:10.1038/s41401-026-01796-8 Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke

medicineneurodegenerationpharmacology

TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury

Hong-Shuo Sun

8d ago

Acta Pharmacologica Sinica, Published online: 27 April 2026; doi:10.1038/s41401-026-01775-z TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury

medicineneurodegenerationpharmacology

Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model

Tian-yan Zhou

11d ago

Acta Pharmacologica Sinica, Published online: 24 April 2026; doi:10.1038/s41401-026-01792-y Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model

immunologymedicineoncologypharmacology

Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition

Oscar Briz

12d ago

Acta Pharmacologica Sinica, Published online: 23 April 2026; doi:10.1038/s41401-026-01791-z Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition

medicineoncologypharmacology

Inhibiting the transient receptor potential melastatin 2 channel in microglia: current evidence and therapeutic potential in neurological disorders

Luiz Roberto G. Britto

12d ago

Acta Pharmacologica Sinica, Published online: 23 April 2026; doi:10.1038/s41401-026-01797-7 Inhibiting the transient receptor potential melastatin 2 channel in microglia: current evidence and therapeutic potential in neurological disorders

medicineneuropharmacologyneurosciencepharmacology

Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice

Bo-rui Zhang

24d ago

Acta Pharmacologica Sinica, Published online: 10 April 2026; doi:10.1038/s41401-026-01785-x Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice

biologyimmunologyneuroscience

Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells

Xun Hu

26d ago

ADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia

Li-fang Hu

26d ago

From calcium signaling to cardiovascular pharmacology: TRPM7 as a key mechanistic regulator and emerging pharmacological focus

Hong-Shuo Sun

26d ago

Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway

Qi-bin Jiao

27d ago

Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment

Yong-zhuo Huang

27d ago

Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cancer

Yong-ping Jian

27d ago

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Acta Pharmacologica Sinica

Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions

Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling

Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5–VEGF signaling axis in macrophages to alleviate myocardial infarction

Targeting endoplasmic reticulum stress and YAP/TAZ-SMAD1/5 signaling to ameliorate endothelial dysfunction in diabetes

Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury

Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke

TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury

Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model

Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition

Inhibiting the transient receptor potential melastatin 2 channel in microglia: current evidence and therapeutic potential in neurological disorders

Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice

Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells

ADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia

From calcium signaling to cardiovascular pharmacology: TRPM7 as a key mechanistic regulator and emerging pharmacological focus

Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potential

5-OH-TMT mitigates colitis through HTRA2 binding–mediated activation of the Dectin-1 signaling pathway

BMAL1 silencing as a promising chemosensitizing strategy for triple-negative breast cancer

Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway

Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment

Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cancer

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