Acta Pharmacologica Sinica

Acta Pharmacologica Sinica, Published online: 12 June 2026; doi:10.1038/s41401-026-01836-3 Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits

Acta Pharmacologica Sinica, Published online: 12 June 2026; doi:10.1038/s41401-026-01808-7 Amyloid-beta fibrils as active contributors to synaptic dysfunction in Alzheimer’s disease

Acta Pharmacologica Sinica, Published online: 11 June 2026; doi:10.1038/s41401-026-01835-4 Epigenetic plasticity in cancer drug resistance: mechanistic insights and strategies for therapeutic intervention

Acta Pharmacologica Sinica, Published online: 11 June 2026; doi:10.1038/s41401-026-01847-0 Paclitaxel prodrug loaded high-density lipoprotein nanoparticles for chemoimmunotherapy of triple-negative breast cancer

Acta Pharmacologica Sinica, Published online: 11 June 2026; doi:10.1038/s41401-026-01840-7 METTL3 loss exacerbates colitis via m 6 A-dependent Slc39a8 regulation and epithelial lineage depletion

Acta Pharmacologica Sinica, Published online: 11 June 2026; doi:10.1038/s41401-026-01825-6 Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis

Acta Pharmacologica Sinica, Published online: 11 June 2026; doi:10.1038/s41401-026-01859-w S1UTRSP5, a short restructured RNA from SLIT1 3′UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity

Acta Pharmacologica Sinica, Published online: 08 June 2026; doi:10.1038/s41401-026-01843-4 Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 reactivates CD8 + T cell immunity and suppresses tumor growth

Acta Pharmacologica Sinica, Published online: 08 June 2026; doi:10.1038/s41401-026-01823-8 Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy

Acta Pharmacologica Sinica, Published online: 08 June 2026; doi:10.1038/s41401-026-01858-x Time-resolved proteomic and phosphoproteomic analysis reveals convergent and divergent biological perturbations induced by FDA-approved CDK4/6 inhibitors in hormone receptor-positive breast cancers

Acta Pharmacologica Sinica, Published online: 04 June 2026; doi:10.1038/s41401-026-01842-5 ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure

Acta Pharmacologica Sinica, Published online: 03 June 2026; doi:10.1038/s41401-026-01830-9 Echoes in the powerhouse: mito-lncRNAs contribution to cardiac function and disease

Acta Pharmacologica Sinica, Published online: 01 June 2026; doi:10.1038/s41401-026-01828-3 Discovery of a novel dual-target modulator of ULK1 and ERK1/2 that suppresses triple-negative breast cancer progression and metastasis via the Exo70/Cav-1/MMPs axis

Acta Pharmacologica Sinica, Published online: 29 May 2026; doi:10.1038/s41401-026-01834-5 Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation

Acta Pharmacologica Sinica, Published online: 27 May 2026; doi:10.1038/s41401-026-01833-6 Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility

Acta Pharmacologica Sinica, Published online: 27 May 2026; doi:10.1038/s41401-026-01827-4 The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure

Acta Pharmacologica Sinica, Published online: 26 May 2026; doi:10.1038/s41401-026-01814-9 T cell-targeted immunotherapies for multiple sclerosis: molecular mechanisms to therapeutic perspectives from Traditional Chinese medicine

Acta Pharmacologica Sinica, Published online: 26 May 2026; doi:10.1038/s41401-026-01810-z TRPM7 kinase: a target for multimodal drug development in neurological disorders

Acta Pharmacologica Sinica, Published online: 26 May 2026; doi:10.1038/s41401-026-01841-6 The spleen-heart crosstalk in cardiovascular disease: integrating neural, immune, and secretory pathways

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01806-9 Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer