Acta Pharmacologica Sinica

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01806-9 Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer

Acta Pharmacologica Sinica, Published online: 25 May 2026; doi:10.1038/s41401-026-01829-2 Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication

Acta Pharmacologica Sinica, Published online: 22 May 2026; doi:10.1038/s41401-026-01831-8 FLRT2 promotes foam cell formation and atherosclerosis by inhibiting USP22-mediated ABCA1 deubiquitination

Acta Pharmacologica Sinica, Published online: 21 May 2026; doi:10.1038/s41401-026-01824-7 G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit

Acta Pharmacologica Sinica, Published online: 21 May 2026; doi:10.1038/s41401-026-01803-y Cell death pathways and targeting therapeutics in cancer therapy

Acta Pharmacologica Sinica, Published online: 20 May 2026; doi:10.1038/s41401-026-01821-w METTL16 S-glutathionylation-triggered RNA m 6 A modification of IGF2BP3 inhibits CFTR expression and promotes chemoresistance in colorectal cancer

Acta Pharmacologica Sinica, Published online: 20 May 2026; doi:10.1038/s41401-026-01813-w Targeting the mitochondrial thermogenesis pathway for neuroprotection in neonatal hypoxic-ischemic encephalopathy by curcumin

Acta Pharmacologica Sinica, Published online: 19 May 2026; doi:10.1038/s41401-026-01812-x The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit

Acta Pharmacologica Sinica, Published online: 19 May 2026; doi:10.1038/s41401-026-01820-x The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01815-8 Solute carrier transporters as metabolic gatekeepers in tumor-microenvironment crosstalk

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01816-7 CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53-mediated expression of SLC7A11 and GPX4

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01826-5 USP22 deubiquitinates and stabilizes ERK1/2 to promote colorectal cancer progression

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01798-6 Correction: Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01837-2 Correction: Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1–NRG2–HECW1 pathway

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01817-6 Targeting fusion proteins in solid tumors: from oncogenic mechanisms to clinical interventions

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01805-w Advances in targeted therapies for pediatric tumors

Acta Pharmacologica Sinica, Published online: 18 May 2026; doi:10.1038/s41401-026-01811-y Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions

Acta Pharmacologica Sinica, Published online: 11 May 2026; doi:10.1038/s41401-026-01818-5 Correction: IG20/MADD gene functional isoform KIAA0358 can promote insulin secretion in glucose and repaglinide-induced pancreatic β-cells

Acta Pharmacologica Sinica, Published online: 07 May 2026; doi:10.1038/s41401-026-01790-0 PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress

Acta Pharmacologica Sinica, Published online: 07 May 2026; doi:10.1038/s41401-026-01793-x CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy