Acta Pharmacologica Sinica

Acta Pharmacologica Sinica, Published online: 09 September 2026; doi:10.1038/s41401-026-01922-6 3-Hydroxydehydroleucodin ameliorates neuroinflammation and ischemic brain injury by blocking the TRIM21-PRDX1 interaction

Acta Pharmacologica Sinica, Published online: 08 September 2026; doi:10.1038/s41401-026-01924-4 Structural basis of β-arrestin coupling and transducer selectivity in PAC1R

Acta Pharmacologica Sinica, Published online: 03 September 2026; doi:10.1038/s41401-026-01884-9 Vasohibin 1 acts as a key regulator of arrhythmogenesis in pressure-overload-induced cardiac hypertrophy

Acta Pharmacologica Sinica, Published online: 02 September 2026; doi:10.1038/s41401-026-01918-2 BioPROTACs: a promising approach for targeted protein degradation

Acta Pharmacologica Sinica, Published online: 01 September 2026; doi:10.1038/s41401-026-01916-4 YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis

Acta Pharmacologica Sinica, Published online: 31 August 2026; doi:10.1038/s41401-026-01914-6 Stevioside promotes hepatocyte proliferation via YAP signaling in cholestatic disease

Acta Pharmacologica Sinica, Published online: 24 August 2026; doi:10.1038/s41401-026-01911-9 Berberrubine alleviates PCS-induced tubular injury via HNRNPF/NR4A1/ER stress axis

Acta Pharmacologica Sinica, Published online: 24 August 2026; doi:10.1038/s41401-026-01915-5 Microglial TLR7 contributes to traumatic brain injury-induced neuroinflammation in mice

Acta Pharmacologica Sinica, Published online: 24 August 2026; doi:10.1038/s41401-026-01910-w Neddylation as a molecular integrator of metabolic dysfunction and endothelial dysfunction in type 2 diabetes

Acta Pharmacologica Sinica, Published online: 24 August 2026; doi:10.1038/s41401-026-01912-8 The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling

Acta Pharmacologica Sinica, Published online: 21 August 2026; doi:10.1038/s41401-026-01880-z Targeting CYBA inhibits hepatic metastasis of pancreatic cancer through AKT/MLC2 pathway

Acta Pharmacologica Sinica, Published online: 21 August 2026; doi:10.1038/s41401-026-01917-3 AKT (Ser473) suppression mediates ceritinib cardiotoxicity through autophagic flux impairment and mitochondrial injury

Acta Pharmacologica Sinica, Published online: 21 August 2026; doi:10.1038/s41401-026-01900-y RNF6 activates the AKT/mTOR signaling pathway by inhibiting PTEN via K27-linked polyubiquitination in myeloma

Acta Pharmacologica Sinica, Published online: 19 August 2026; doi:10.1038/s41401-026-01909-3 A prelimbic cortex-lateral hypothalamus circuit regulates acquisition of alprazolam-induced conditioned place preference in male mice

Acta Pharmacologica Sinica, Published online: 18 August 2026; doi:10.1038/s41401-026-01906-6 SRPK3 exacerbates cardiac ischemia/reperfusion injury by regulating KLF3-mTOR/P70 S6K-mediated autophagy

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01902-w Direct β-arrestin engagement by the non-canonical WNT receptor FZD6 via a shallow binding pocket

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01896-5 Oxyberberine-nanoparticle attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating gut microbiota through suppressing CXCL10/CXCR3 pathway

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01894-7 PDE4D-CXCL13 axis in gland epithelial cells promotes B cell infiltration in primary Sjögren’s syndrome

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01899-2 Tumor-driven arginine depletion induces T-cell metabolism reprogramming to suppress atherosclerosis in colorectal cancer

Acta Pharmacologica Sinica, Published online: 17 August 2026; doi:10.1038/s41401-026-01903-9 Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development