Lycium barbarum glycopeptide confers neuroprotection in chronic ocular hypertensive rats: a study investigating visual function, retinal structure, microcirculation, and pyroptosis
Xuejing Lu
BackgroundLycium barbarum glycopeptide (LbGp) has been reported to exert neuroprotective effects, yet its role in chronic ocular hypertension (COH) and the underlying mechanisms remain unclear. This study investigated whether LbGp protects against COH-induced retinal damage by inhibiting pyroptosis.MethodsA COH rat model was established, and the animals were randomly assigned to model, LbGp, VX-765 (pyroptosis inhibitor), and VX-765+LbGp groups. After 28 days of treatment, visual function, retin