nephrology

IntroductionSubclinical Diabetic Kidney Disease (subDKD) is a clinically silent stage of kidney disease secondary to diabetes mellitus (DM), being a public health problem worldwide. The pathogenic mechanism involves hyperglycemia-induced tubulointerstitial injury associated with dysfunction of tubular protein reabsorption and proteinuria, even without any clinical signs like impaired glomerular f…

Kidney disease can develop quietly, and many people do not realize they have it until significant damage has already occurred. This is especially important for older adults because some warning signs can look like ordinary changes associated with aging. The kidneys are two small, bean-shaped organs located toward the back of the body. Although small, […] The post Kidney Disease Can Hide Behind Ev…

BackgroundRenal fibrosis is a common pathological outcome of chronic kidney disease and is characterized by persistent profibrotic signaling and impaired cellular homeostasis. Genkwanin (GAK), a natural flavonoid compound, has shown anti-inflammatory and antioxidant activities in several disease models. However, its role in renal fibrosis remains unclear.Materials and methodsWe investigated the a…

American Journal of Infectious Diseases, Published online: 6 August 2026; doi:10.3844/ajidsp.2026.1.3 Leptospirosis is a zoonosis caused by the spirochete Leptospira, which commonly affects the kidneys. Varied renal findings, most commonly tubulointerstitial nephritis, are found in human kidney biopsi...

This cohort study examines the association between apolipoprotein L1 gene polymorphisms and kidney function after living kidney donation.

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited condition where cysts filled with fluid develop on the kidneys. The cysts can grow larger over time and impact kidney function, leading to kidney failure.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to have significant nephroprotective effects, though the evidence lies almost exclusively with injectable formulations. Orforglipron is a novel oral, once-daily, non-peptide small-molecule GLP-1 RA with a distinct pharmacological mechanism compared to other GLP-1 RAs on the market. Unlike its predecessors, which bind an orthost…

Chronic kidney disease is a long-lasting condition in which the kidneys gradually stop working as well as they should. In the early stages, many people have few symptoms, but the disease can slowly lead to kidney failure and increase the risk of heart problems. Finding treatments that slow this process is one of the biggest […] The post Major study finds existing drug protects kidneys even in peo…

An international study found that finerenone slows kidney function decline and reduces the risk of serious kidney and cardiovascular complications in people with chronic kidney disease who do not have diabetes. The results could open the door to a much-needed new treatment option for the majority of CKD patients who have long had limited choices.

People living with chronic kidney disease (CKD) face much more than problems with their kidneys. They are also far more likely to develop heart disease, which is one of the main causes of death in this group. Doctors have known for many years that people with CKD often have ongoing inflammation throughout the body, but […] The post Chronic Kidney Disease is Linked to Heart Damage, Study Finds app…

Chronic kidney disease (CKD) and cardiovascular disease are bidirectionally linked, with metabolic reprogramming as a central pathophysiological nexus. This review examines metabolic disturbances underlying CKD–CVD comorbidity, including energy metabolism disorders, mitochondrial dysfunction, lipid and glucose dysregulation, and mineral metabolism abnormalities. The gut microbiota–metabolic axis …