nephrology

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04343-4 A nine-protein plasma signature is predictive of kidney events and mortality in individuals with a high-risk APOL1 genotype and preserved estimated glomerular filtration rate, outperforming existing clinical and genetic risk tools and providing a biologically plausible marker set for early intervention and trial enrich…

Chronic kidney disease, often called CKD, is a long-term condition where the kidneys slowly lose their ability to work properly. The kidneys are very important because they clean waste and extra fluid from the blood. When they are damaged, harmful substances can build up in the body. Over time, this can lead to serious health […] The post Eating less protein may help protect kidneys, study shows …

Nature Medicine, Published online: 30 April 2026; doi:10.1038/d41591-026-00025-3 After years of limited options, a surge of targeted therapies — from immunomodulators to genetically defined drugs — is starting to reshape treatments for kidney disease.

A detailed new map of the human kidney revealed a previously unrecognized form of diabetic kidney disease (DKD) marked by clusters of immune cells-specifically B cells-that are linked to faster disease progression.

Hypertension and chronic kidney disease frequently coexist and mutually accelerate cardiovascular and renal injury. This narrative review prioritizes direct human autonomic phenotyping (Level 1: microneurography, HRV/BRS), human vascular correlates (Level 2: PWV, FMD), and complementary preclinical evidence (Level 3) to elucidate autonomic-vascular mechanisms. Autonomic imbalance, characterized b…

BackgroundHyperphosphataemia is consistently linked to adverse clinical outcomes in Acute Kidney Injury (AKI). Sevelamer, a non-calcium phosphate binder widely used in chronic kidney disease (CKD), has not been adequately evaluated for efficacy in AKI.MethodsWe performed a retrospective cohort analysis in the MIMIC- IV database. The association between sevelamer exposure and 28- day all-cause mor…

A five-year, multisite clinical trial will compare two medication strategies for advanced chronic kidney disease, enrolling 1,350 participants nationwide. Advanced chronic kidney disease (CKD) affects over 1 million people in the US. Individuals with advanced CKD have high risks of kidney failure requiring dialysis or transplantation, cardiovascular events, hospitalizations, and death, as well as…

Nephrology papers need pre-submission review that checks kidney phenotype, endpoints, mechanisms, reporting, statistics, and journal fit.

BackgroundRenal fibrosis (RF) is a refractory disease characterized by excessive deposition of extracellular matrix, leading to tissue damage and scar formation. Fructus arctii (the dried ripe fruit of Arctium lappa L.) is a typical medicinal and edible plant widely utilized in both traditional medicine and culinary practices, rich in lignans, phenolic acids, and dietary fibers. Studies have show…

BackgroundCisplatin-induced nephrotoxicity is a major dose-limiting complication of chemotherapy. However, effective protective strategies remain limited. Licochalcone A (LicoA), a flavonoid isolated from Glycyrrhiza inflata, exhibits multi-target bioactivity against oxidative stress, inflammation, and metabolic disorders.MethodsIn vivo murine cisplatin-induced model and in vitro HK-2 cells were …

Scientific Reports, Published online: 17 April 2026; doi:10.1038/s41598-026-48165-3 Early kinetics of anti-PLA2R-IgG4 predicts rituximab response in membranous nephropathy: a prospective biomarker study

Diabetic kidney disease is one of the most serious problems caused by diabetes. It affects about 40% of people with diabetes and can slowly damage the kidneys over time. When the disease becomes severe, some people may need dialysis or even a kidney transplant to survive. Because of this, finding better ways to protect the […] The post Simple blood pressure drug may protect kidneys in diabetes, s…

Yang & colleagues demonstrate a peptide vaccine targeting the metalloproteinase ADAMTS7 mitigates the damage to the kidneys & blood vessels related to chronic kidney disease. Learn more at. ELetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are no

Kidney International Supplements operates on a supplement model, not a standard open-submission research journal. Before submitting, understand how the KDIGO process and ISN-organized issues work.

This article is part of “Innovations In: Kidney Disease,” an editorially independent special report that was produced with financial support from Vertex. The man in his 50s arrived at Ellie Kelepouris’s office carrying a sheaf of medical records. They contained years’ worth of laboratory test results that showed microscopic traces of blood in his urine. Kelepouris, a nephrologist at the Universit…

This article is part of “Innovations In: Kidney Disease,” an editorially independent special report that was produced with financial support from Vertex. More than one in seven people in the U.S. have chronic kidney disease, which was the ninth-leading cause of death worldwide in 2023. But until recently, just one class of drugs—called renin-angiotensin system (RAS) inhibitors—had been shown to s…

This article is part of “Innovations In: Kidney Disease,” an editorially independent special report that was produced with financial support from Vertex. Dennis Moledina encountered a common problem during his training in nephrology, the specialty dedicated to kidney health. Many of the patients he saw had acute kidney injury that had been caused not directly by a disease but by a prescribed medi…

Nature Reviews Nephrology does not accept unsolicited primary research. Here is what the invitation model means for nephrology researchers and where primary research papers belong.

Scientists have discovered previously unknown cellular mechanisms that regulate the production of renin, an essential enzyme in the kidney, findings that could improve the understanding of how the kidney regulates its function and how chronic kidney disease develops, according to a recent study published in Cell. The post Novel Mechanism Regulates Essential Enzyme Production in Kidneys appeared f…

"Developing new therapies and treatments for CKD can help prevent or put off more drastic treatments—like dialysis or transplantation..."