nephrology

A new review has illuminated a critical but often overlooked dimension of autosomal dominant polycystic kidney disease (ADPKD)—its immune microenvironment.

Chronic kidney disease, also known as CKD, is a major health problem that affects millions of people around the world. The kidneys play a very important role in keeping the body healthy. They remove waste and extra fluid from the blood, help control blood pressure, and keep important minerals balanced. When the kidneys slowly lose […] The post A constipation drug may help treat chronic kidney dis…

High blood pressure, also called hypertension, is one of the most common health problems in the world. Millions of people live with it every day, and many may not even know they have it because the condition often develops silently over time. If high blood pressure is not treated properly, it can seriously damage the […] The post Popular blood pressure drugs may affect the kidneys in unexpected w…

BackgroundDiabetic kidney disease (DKD) is one of the leading causes of end-stage kidney disease worldwide, and microbiota-based interventions are considered potential preventive and therapeutic strategies to slow its progression. This study evaluated the efficacy of probiotic supplementation in patients with DKD through a systematic review and meta-analysis.MethodsWe searched seven databases, in…

BackgroundCisplatin chemotherapy is limited by its nephrotoxicity, which leads to acute kidney injury (AKI). Ferroptosis is a key pathogenic mechanism in cisplatin-induced AKI. Formononetin (FN), a natural isoflavone, has demonstrated antioxidant and renoprotective potential, but its role in modulating ferroptosis remains unclear.MethodsA cisplatin-induced AKI model in mice and a cisplatin-injure…

Acta Pharmacologica Sinica, Published online: 07 May 2026; doi:10.1038/s41401-026-01793-x CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04343-4 A nine-protein plasma signature is predictive of kidney events and mortality in individuals with a high-risk APOL1 genotype and preserved estimated glomerular filtration rate, outperforming existing clinical and genetic risk tools and providing a biologically plausible marker set for early intervention and trial enrich…

Chronic kidney disease, often called CKD, is a long-term condition where the kidneys slowly lose their ability to work properly. The kidneys are very important because they clean waste and extra fluid from the blood. When they are damaged, harmful substances can build up in the body. Over time, this can lead to serious health […] The post Eating less protein may help protect kidneys, study shows …

Nature Medicine, Published online: 30 April 2026; doi:10.1038/d41591-026-00025-3 After years of limited options, a surge of targeted therapies — from immunomodulators to genetically defined drugs — is starting to reshape treatments for kidney disease.

A detailed new map of the human kidney revealed a previously unrecognized form of diabetic kidney disease (DKD) marked by clusters of immune cells-specifically B cells-that are linked to faster disease progression.

Hypertension and chronic kidney disease frequently coexist and mutually accelerate cardiovascular and renal injury. This narrative review prioritizes direct human autonomic phenotyping (Level 1: microneurography, HRV/BRS), human vascular correlates (Level 2: PWV, FMD), and complementary preclinical evidence (Level 3) to elucidate autonomic-vascular mechanisms. Autonomic imbalance, characterized b…

BackgroundHyperphosphataemia is consistently linked to adverse clinical outcomes in Acute Kidney Injury (AKI). Sevelamer, a non-calcium phosphate binder widely used in chronic kidney disease (CKD), has not been adequately evaluated for efficacy in AKI.MethodsWe performed a retrospective cohort analysis in the MIMIC- IV database. The association between sevelamer exposure and 28- day all-cause mor…

A five-year, multisite clinical trial will compare two medication strategies for advanced chronic kidney disease, enrolling 1,350 participants nationwide. Advanced chronic kidney disease (CKD) affects over 1 million people in the US. Individuals with advanced CKD have high risks of kidney failure requiring dialysis or transplantation, cardiovascular events, hospitalizations, and death, as well as…

Nephrology papers need pre-submission review that checks kidney phenotype, endpoints, mechanisms, reporting, statistics, and journal fit.

BackgroundRenal fibrosis (RF) is a refractory disease characterized by excessive deposition of extracellular matrix, leading to tissue damage and scar formation. Fructus arctii (the dried ripe fruit of Arctium lappa L.) is a typical medicinal and edible plant widely utilized in both traditional medicine and culinary practices, rich in lignans, phenolic acids, and dietary fibers. Studies have show…

BackgroundCisplatin-induced nephrotoxicity is a major dose-limiting complication of chemotherapy. However, effective protective strategies remain limited. Licochalcone A (LicoA), a flavonoid isolated from Glycyrrhiza inflata, exhibits multi-target bioactivity against oxidative stress, inflammation, and metabolic disorders.MethodsIn vivo murine cisplatin-induced model and in vitro HK-2 cells were …

Scientific Reports, Published online: 17 April 2026; doi:10.1038/s41598-026-48165-3 Early kinetics of anti-PLA2R-IgG4 predicts rituximab response in membranous nephropathy: a prospective biomarker study

Diabetic kidney disease is one of the most serious problems caused by diabetes. It affects about 40% of people with diabetes and can slowly damage the kidneys over time. When the disease becomes severe, some people may need dialysis or even a kidney transplant to survive. Because of this, finding better ways to protect the […] The post Simple blood pressure drug may protect kidneys in diabetes, s…

Yang & colleagues demonstrate a peptide vaccine targeting the metalloproteinase ADAMTS7 mitigates the damage to the kidneys & blood vessels related to chronic kidney disease. Learn more at. ELetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are no