nephrology

Chronic kidney disease is one of the world’s fastest-growing health problems, affecting an estimated 850 million people globally. Many people do not realize they have the condition until significant damage has already occurred because kidney disease often develops slowly and quietly over many years. As kidney function declines, waste products and excess fluid can build […] The post Kidney Drug Co…

BackgroundRoxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia in patients with chronic kidney disease (CKD); however, evidence from randomized trials has not fully clarified its associations with thrombotic outcomes and all-cause mortality.MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane Library from inception to 21 August 2025 for r…

An investigator at the Icahn School of Medicine at Mount Sinai has received international recognition for innovative imaging research that may help physicians identify patients at increased risk of chronic kidney disease (CKD) before they undergo surgery for kidney tumors.

For decades, chronic kidney disease has been a difficult condition to treat. Once kidney function begins to decline, doctors can often slow the damage but rarely stop it completely. Millions of patients eventually face dialysis, kidney transplantation, serious heart complications, or early death. New research now suggests that an existing medicine called finerenone may offer […] The post This Kid…

For people living with type 2 diabetes, protecting kidney health is often a lifelong challenge. Diabetes is one of the leading causes of chronic kidney disease, and many patients also develop high blood pressure. Together, these conditions can gradually damage the kidneys and increase the risk of serious complications. Over the last decade, doctors have […] The post How Blood Pressure Drugs Affec…

Introduction: Cisplatin is a key drug used for anticancer therapy. However, its use is often accompanied by the development of acute kidney injury. The aim of this study was to develop an optimal model of cisplatin-induced kidney injury in rats and use it to study the nephroprotective properties of polydatin . Materials and Methods. The experiment was performed in 100 male Wistar rats. To test th…

A series of major studies has shown that finerenone preserves kidney function, reduces cardiovascular risk, and improves survival across a much broader range of patients with chronic kidney disease (CKD) than it is currently recommended for.

Every day your kidneys filter something like 180 litres of blood, sieving out waste while clinging to the things your body wants to keep. When that machinery starts to fail, it rarely does so loudly. Protein begins leaking into the urine, the filtration rate creeps downward, and the slide, once it starts, tends to keep going. For a huge slice of patients, doctors have had little to throw at that …

ObjectivesThis study aimed to explore the sex-specific regulatory effects of empagliflozin on gut microbiota in male and female diabetic kidney disease (DKD) mice, and to elucidate the underlying renoprotective mechanisms.MethodsFour-week-old db/db mice and C57 mice were randomly assigned to six groups. Following 8 weeks of empagliflozin gavage, serum metabolic indices and urinary albumin-to-crea…

BackgroundImmunoglobulin A nephropathy (IgAN) has a high incidence rate and a poor prognosis. Currently, no ideal treatment is available for this disease. Despite some reports on the use of telitacicept in IgAN, studies with a treatment duration of 24 weeks or longer remain limited, and data on its combination with glucocorticoids are currently lacking.MethodsThis retrospective cohort study enrol…

Proteinuria is a well-established risk factor for chronic kidney disease progression, and its reduction is associated with improved kidney outcomes. During proteinuric chronic kidney diseases, the abnormal passage of plasma-derived proteins through the damaged glomerular filtration barrier can lead to the activation of various pathophysiological processes in the tubular compartment. These mainly …

Hypertensive Chronic Kidney Disease (CKD) constitutes a significant global health burden, characterized by a vicious cycle of hypertension and progressive renal decline. Autonomic imbalance, specifically sympathetic overactivity and parasympathetic withdrawal, is increasingly recognized as a central driver of this pathophysiology, interacting with traditional hemodynamic factors such as RAAS acti…

A new review has illuminated a critical but often overlooked dimension of autosomal dominant polycystic kidney disease (ADPKD)—its immune microenvironment.

Chronic kidney disease, also known as CKD, is a major health problem that affects millions of people around the world. The kidneys play a very important role in keeping the body healthy. They remove waste and extra fluid from the blood, help control blood pressure, and keep important minerals balanced. When the kidneys slowly lose […] The post A constipation drug may help treat chronic kidney dis…

High blood pressure, also called hypertension, is one of the most common health problems in the world. Millions of people live with it every day, and many may not even know they have it because the condition often develops silently over time. If high blood pressure is not treated properly, it can seriously damage the […] The post Popular blood pressure drugs may affect the kidneys in unexpected w…

BackgroundDiabetic kidney disease (DKD) is one of the leading causes of end-stage kidney disease worldwide, and microbiota-based interventions are considered potential preventive and therapeutic strategies to slow its progression. This study evaluated the efficacy of probiotic supplementation in patients with DKD through a systematic review and meta-analysis.MethodsWe searched seven databases, in…

BackgroundCisplatin chemotherapy is limited by its nephrotoxicity, which leads to acute kidney injury (AKI). Ferroptosis is a key pathogenic mechanism in cisplatin-induced AKI. Formononetin (FN), a natural isoflavone, has demonstrated antioxidant and renoprotective potential, but its role in modulating ferroptosis remains unclear.MethodsA cisplatin-induced AKI model in mice and a cisplatin-injure…

Acta Pharmacologica Sinica, Published online: 07 May 2026; doi:10.1038/s41401-026-01793-x CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy

Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04343-4 A nine-protein plasma signature is predictive of kidney events and mortality in individuals with a high-risk APOL1 genotype and preserved estimated glomerular filtration rate, outperforming existing clinical and genetic risk tools and providing a biologically plausible marker set for early intervention and trial enrich…