molecular-biology

Ok so, the parabiosis was a temporary effect, but the answer turned out to be having a blood transfusion with yourself instead. So if this video is right there is a molecule called HMGB1 which can be blocked rather than having said transfusion. Scientists may have identified one of the molecules that helps aging spread […]

Arecoline, the major alkaloid of areca nut, is a common exposure in chewing products, but its relationship with prostate cancer (PCa) is unclear. We integrated network toxicology, bulk RNA machine learning, single-cell transcriptomics, molecular simulation, and in vitro validation to prioritize candidate molecular nodes potentially linking arecoline exposure to PCa-related alterations. Potential …

Nature Communications, Published online: 04 June 2026; doi:10.1038/s41467-026-73806-6 MET upregulation drives many human cancers. Herein, the authors identify a G-quadruplex in the MET promoter that recruits LRPPRC to boost MET transcription, and show that nitidine acts as a molecular glue to stabilize the LRPPRC–MET-G4 complex, suppressing MET expression and inhibiting tumor growth.

Congratulations to Michel DuPage on his promotion to MCB Associate Professor of Immunology and Molecular Medicine! The DuPage Lab focuses on epigenetic control of the functional plasticity of T cells in disease. Read more about the DuPage Lab and their research here .

RNA sequencing, commonly called RNA-seq, is a high-throughput sequencing method used to study the transcriptome. The transcriptome includes the RNA molecules expressed in a cell, tissue, organism, or biological condition.... The post RNA-Seq: Principles, Workflow, Data Analysis, and Applications in Transcriptomics appeared first on THE SCIENCE NOTES .

In this Q&A, Paul Babitzke, Don Bryant Chair in Microbial Physiology, and Philip Bevilacqua, distinguished professor of chemistry and of biochemistry and molecular biology, shared about the history of the Center for RNA Molecular Biology and the importance of its annual symposium.

Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10582-9 NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.

While scientists have known for over two decades that all cells use a strategy called RNA interference to regulate gene expression, a new study is the first to describe how a specific protein manages the step-by-step process of assembling the molecular complex that performs the regulatory job.

Nature Communications, Published online: 25 May 2026; doi:10.1038/s41467-026-72986-5 Combining NMR spectroscopy, AlphaFold modelling and biolayer interferometry, hepatitis B virus protein X (HBx) is shown to mask human Spindlin1 through a zinc-finger mediated interaction, blocking histone binding and altering transcriptional control.

Check out this new paper that Jordan led with an incredible team of researchers across Newcastle University (including our very own Ben Hawthorne) and the University of Innsbruck, now published in Molecular Ecology Resources! Dietary RNA: integration of RNA data offers a potential paradigm shift for molecular dietary analyses It’s been just over two decades Continue reading "NEW PAPER: Dietary RN…

Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10530-7 High-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe identifies SNOR protein, which binds to ribosomes during dormancy induced by glucose depletion, priming them for rapid reactivation of protein synthesis upon glucose repletion.

RNA splicing is a fundamental driver of eukaryotic transcriptomic and proteomic diversity. Constrained by compact genomes, diverse DNA and RNA viruses, including adenovirus, HIV-1, and influenza virus, have evolved to hijack the host splicing machinery. This exploitation not only maximizes viral coding capacity but also ensures the precise spatiotemporal regulation of viral infection. In this rev…

Event Details This comprehensive course equips learners with essential and advanced biotechnology techniques — from molecular biology, microbiology, and biochemistry to genomics and analytical methods. It emphasizes practical understanding, experimental design, troubleshooting, and data interpretation, preparing participants for real-world research, diagnostics, and industry applications with str…

Headquartered in Tokyo – with a European Research facility in Munich – the company focuses on developing and delivering innovative new medicines, alongside advanced drug discovery and delivery methodologies, which serve patients globally. CPP members benefit from direct connection with EMBL’s world-leading molecular biology research, services, and technology development, and their support enables…

Paediatric asthma is a chronic inflammatory airway disease that can cause airway swelling, excessive mucus secretion, and increased smooth muscle tone, leading to airway narrowing and respiratory distress. Airway remodelling involves a series of pathophysiological alterations, including airway epithelial injury, proliferation of mucous glands and goblet cells, subepithelial fibrosis, proliferatio…

Inside every cell in your body, right now, a molecular machine is threading its way along a strand of DNA and reading it. The enzyme is called RNA polymerase II, and it is perhaps the most consequential piece of biological machinery evolution has ever produced: without it, none of your genes get expressed, no proteins get made, nothing works. Scientists have known this for decades. What they have…