Frontiers in Chemistry | New and Recent Articles

Stimuli-responsive nanotherapy (SRN) has emerged as a promising therapeutic strategy that employs nanosensitizers activated by external physical or chemical stimuli to generate reactive species for disease treatment. Among various nanosensitizers, metal nanoparticles (MNPs) have attracted considerable attention owing to their unique physicochemical properties, including tunable optical responses,…

Doxorubicin (DOX) is a cornerstone anthracycline in breast cancer therapy, but its use is constrained by cumulative cardiotoxicity. We asked whether conjugation to a guanidinium-rich cell-penetrating peptidomimetic widens the window between anticancer activity and cardiomyocyte toxicity, or merely rescales potency. DOX was linked by azide–alkyne click chemistry to an eight-guanidinium peptidomime…

IntroductionRapid and simultaneous detection of respiratory syncytial virus A (RSV A) and RSV B with subtype discrimination is important for point-of-care (POC) diagnostics and epidemiological surveillance.MethodsWe developed the RSV A/B rh-RT-LAMP-NALF assay, a duplex reverse transcription loop-mediated isothermal amplification (RT-LAMP) system combined with nucleic acid lateral flow (NALF) dete…

Zeolites are porous materials with regular nanochannels, high surface area, tunable acid sites, excellent thermal and hydrothermal stability, and outstanding catalytic performance. These properties make them indispensable in energy and chemical engineering, environmental remediation, selective adsorption, and clean energy technologies. However, conventional hydrothermal synthesis suffers from hig…

The rising incidence of antimicrobial resistance necessitates the development of sustainable and eco-friendly nanomaterials. In this study, silver-iron oxide nanoparticles (Ag-FeO NPs) were phyto-synthesized using Traganum nudatum seed extract as a natural reducing and stabilizing agent, and their physicochemical properties and antimicrobial activity were systematically evaluated. UV-Vis spectros…

To ensure stable quality of colored cigarette paper dyed with natural dyes, real-time kinetic data of dye adsorption onto cellulosic fibers remains insufficient due to limitations of traditional offline sampling methods. In this work, brown natural dye was used as the adsorbate, and an online UV-Vis spectral monitoring system was developed to achieve continuous, non-destructive detection of the f…

IntroductionAromatic amines released from azo dyes are regulated in textile products under the European REACH framework due to their potential health risks. Their determination remains analytically challenging because of their structural similarity, moderate polarity, and the complexity of textile matrices, which can cause significant matrix effects.MethodsA green Capillary Electrophoresis method…

Hydrogen is considered one of the most promising energy carriers for low-carbon energy systems. However, hydrogen embrittlement (HE) poses a threat to the structural integrity and long-term reliability of metallic materials used in hydrogen production, storage, transportation, and utilization. Microstructural features such as dislocations, vacancies, grain boundaries, precipitates, and phase inte…

Fibroblast activation protein (FAP) is a highly specific biomarker overexpressed in cancer-associated fibroblasts, making it a promising diagnostic target. Developing novel high-affinity molecular probes for FAP-targeted diagnostics remains an active area of research. In this study, an integrated computational pipeline combining generative artificial intelligence, molecular docking, molecular dyn…

Recognition of amyloid-β (Aβ) by structurally defined inorganic scaffolds offers a route to dissecting how framework geometry and surface chemistry govern peptide–material interactions. We report transferrin (Tf)/KLVFF-PCN-222, a bioinorganic recognition platform built by covalently co-grafting the Aβ-homologous pentapeptide KLVFF and transferrin (Tf) onto the csq-topology porphyrinic zirconium M…

Recent advances in the precise control of electromagnetic and transport properties, and the miniaturization of electronic devices, have introduced new prospects in the development of practical quantum computing. Double perovskites have gained particular attention in spintronic applications due to their structural stability, non-toxicity, and inherent spin polarization. In this study, we explore t…

Copper is an essential micronutrient whose redox activity underpins a dual role in immunity: it serves as both an antimicrobial effector and a regulator of inflammatory signaling. Macrophages, as central orchestrators of innate and adaptive immunity, maintain sophisticated copper homeostasis mechanisms that dynamically adapt to distinct activation states and environmental cues. This review synthe…

IntroductionMolecular hybridization is an effective approach employed to synthesize molecules that possess the ability to function as dual inhibitors, thereby addressing the issue of growing resistance. Resistance by the malaria parasite is one such example. Therefore, the study aims to develop hybrid compounds consisting of 4-aminoquinoline and 4-thiazolidinone, utilizing molecular docking for s…

Real-time quantitative analysis of complex matrices (e.g., moisture and multiple components) is a critical bottleneck in modern Process Analytical Chemistry (PAC). While online near- and mid-infrared spectroscopy are widely deployed, achieving high-fidelity measurements in dynamic industrial environments remains highly challenging. Severe matrix effects coupled with industrial multi-stress interf…

Lead halide perovskite light-emitting diodes (PeLEDs) have emerged as highly promising candidates for next-generation displays and solid-state lighting, achieving record-high external quantum efficiencies (EQEs) exceeding 30%. The perovskites possess outstanding optoelectronic properties, such as high photoluminescence quantum yields (PLQY), narrow full-width at half maximum (FWHM), and efficient…

IntroductionBiomonitoring of commercial endocrine-disrupting chemicals (EDCs) increasingly underpins exposure assessment and risk evaluation, yet most large-scale studies still rely on indirect, enzymatic hydrolysis–based methods whose quantitative performance has not been systematically verified. Here, we describe the development and rigorous validation of a direct liquid chromatography-tandem m…

IntroductionThe sustainable design of jewelry materials has become a critical focus in the pursuit of environmental conservation and responsible manufacturing practices. Traditional approaches to jewelry grade polymer development often prioritize aesthetic and structural qualities while neglecting environmental considerations, leading to significant ecological footprints and limited adaptability …

The persistence of resistance, recurrence, and limited selectivity in cancer therapy necessitates the development of structurally advanced antitumor agents capable of modulating multiple intracellular pathways. This review provides a systematic analysis of nitrogen- and oxygen-containing heterocycles as key platforms in anticancer drug design, with an emphasis on integrated molecular architecture…

BackgroundLithium, sulfur batteries are promising next-generation energy, storage systems, but their practical performance is limited by lithium polysulfide (LiPS) shuttling, sluggish sulfur redox kinetics, insulating Li2S formation, and performance decay under high-sulfur-loading and lean-electrolyte conditions.MethodsSingle-atom Ru–NC was synthesized through precursor coordination, pyrolysis, a…

IntroductionGreen-synthesized metal nanoparticles, primarily derived from plant sources, have attracted interest due to their inherent sustainability. In this study, we reported the green synthesis of zinc oxide nanoparticles (ZnO NPs) using an aqueous extract of dried lemon peel. In addition, antibacterial activity and in silico analysis of the as-prepared ZnO NPs were performed.MethodsDifferent…