Frontiers in Chemistry | New and Recent Articles

Acidified oil wastewater contains high concentrations of phosphorus and organic pollutants, which not only pose environmental risks but also contain recoverable phosphorus resources. However, its complex matrix (high COD and acidic environment) poses great challenges to phosphorus recovery technologies. This study successfully developed a new phosphorus recovery strategy adapted to the wastewater…

Peptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often interpreted uncritically as evidence of improved molecular design. This Perspective highlights that lipidation can reshape peptide behaviour by partially shifting functional control…

In marine environments, the increased drag force on vehicles impedes their speed underwater, leading to high energy consumption and reduced vehicle efficiency. Superhydrophobic coatings have gained remarkable attention regarding drag reduction. Due to the collapse of the air plastron, the change from Cassie–Baxter to Wenzel state at high fluid impalement pressures, and various chemical conditions…

IntroductionFive new quinazoline-sulfonamide hybrids 4a (MZ-13), 4b (MZ-20), 4c (MZ-25), 4d (MZ-26), and 6a (MZ-29) were designed, synthesized, and investigated for their in vitro and in vivo antidiabetic activities.MethodsThe in vivo screening was conducted in a mouse model of type II diabetes induced by streptozotocin (STZ), using glibenclamide as the positive control. The in vitro model was pe…

BackgroundPoly (1,4-bis(methacryloyl)piperazine) (poly (NBMP)) is a piperazine-based polymer with potential biomedical applications. Green clay catalysts, maghnite-H+ and maghnite-Na+; offer an eco-friendly approach for monomer (NBMP) and polymer (poly (NBMP)) synthesis with improved yields and low toxicity.AimTo synthesize poly (NBMP) via green catalysis, evaluate its structural properties, and …

Natural deep eutectic solvents (NDESs) are promising biomass pretreatment media, but their industrial application is often hindered by high viscosity. To address this limitation, diol-enhanced ternary DESs (TDESs) were prepared by incorporating 1,4-butanediol (1,4-BDO) or ethylene glycol (EG) into a choline chloride (ChCl) and 3,4-dihydroxybenzoic acid (DHBA) system. The applied TDESs maintained …

To circumvent the general lack of selectivity of protein kinase inhibitors, a chemical genetics approach has been developed to allow the selective targeting of engineered kinases by bulky ATP analogs, most of which derived from the pyrazolo[3,4-d]pyrimidine 1 (PP1) inhibitor. Although designed to selectively inhibit so-called analog-sensitive (AS) kinases presenting enlarged active sites, bulky P…

IntroductionAccurate prediction of drug-target affinity is important for computational drug discovery, yet many deep learning models show limited robustness when applied to unseen compounds or previously uncharacterized proteins.MethodsWe developed CS-DTA, a modular DTA prediction framework that integrates large language models (LLMs) for compound and protein representation learning with a cross-…

The heterocyclic compound is one of the finest spanned backbones for developing most innovative agents in the pharmaceutical industry. These adaptable molecules have played an important role in the discovery of therapeutic agents of a wide range, including antibiotics, anticancer drugs and antivirals. The role of heterocyclic chemistry in pharmaceutical innovation is thus one that extends beyond …

In the present study, high-impact polystyrene (HIPS) nanocomposites filled with nano-silicon In the present study, high-impact polystyrene (HIPS) nanocomposites filled with nano-silicon particles (Si) and multi-walled carbon nanotubes (MWCNTs) were prepared, their structural, dielectric, and mechanical properties were investigated. X-ray diffraction (XRD) analysis confirmed the polycrystalline na…

This study successfully constructed shikonin-Co nanoparticles (Co-Shik NPs) and systematically evaluated their healing effects on diabetic wounds. The nanoparticles, prepared via a self-assembly method, exhibited uniform particle size and stable structure. In vitro experiments demonstrated that the material showed no cytotoxicity at a concentration of 16 mg/L, significantly scavenged reactive oxy…

This study introduces a sustainable and efficient method for synthesizing quinazolinones, a class of heterocyclic compounds with significant pharmaceutical applications, via a multicomponent reaction (MCR) strategy. The process employs a novel magnetically recoverable palladium catalyst, enabling the coupling of aryl or heteroaryl iodides with a carbonyl source and 2-aminobenzamide in an eco-frie…

Tumor immunity arises from the coordinated action of innate and adaptive immune systems but is hindered by immune escape within the immunosuppressive tumor microenvironment (TME), for which ion channels and ion pumps have proved to be important. These proteins regulate a wide range of cellular processes to influence cancer progression and immune cell functions, of which ion channels maintain intr…

Bacterial infections, especially those involving drug-resistant pathogens and biofilms, pose a severe global health threat. Conventional antibiotic therapies are limited by poor penetration, low specificity, and bacterial resistance mechanisms. Magnetic nanoparticles (MNPs) offer a promising alternative by combining magnetically guided targeting, magnetothermal/photothermal effects, multifunction…

IntroductionIn cancer therapy, inhibiting tubulin polymerization is a key approach for modifying microtubule dynamics required for cell survival and proliferation. Microtubule destabilizing agents (MDAs), also known as tubulin polymerization inhibitors, prevent tubulin heterodimers from forming microtubules, resulting in catastrophic cellular collapse.MethodsA novel series of thiazole-based compo…

In recent years, the prevalence of myopia has sharply increased in East Asia, emerging as a major public health issue. This study aimed to identify genetic risk factors for myopia progression and to develop polygenic risk score (PRS) models to predict myopia progression risk. Genotyping was performed using the Asian Screening Array chip among 294 Chinese adolescents who completed a 2-year follow-…