Nature Communications, Published online: 25 July 2026; doi:10.1038/s41467-026-75985-8 The lncRNA Trdn-as regulates the formation of the cardiac-specific TRDN isoform through transcriptional interference and m6A modification. This is crucial for accurate cardiac dyad calcium release and prevents QT prolongation and cardiomyopathy.
Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy
Thomas Boettger