chronic-pain

A highly anticipated drug trial is in its final stages as its 350 participants receive their single dose to treat chronic low back pain. If successful, the experimental medication could be a breakthrough therapeutic for people with the common but debilitating condition. Continue Reading Category: Chronic Pain , Illnesses and conditions , Body and Mind , Refractor: Science & Health Tags: Cells , B…

Deep at the base of the brain, a tiny cluster of nerve cells serves as the body's natural pain reliever, dialing down pain signals traveling up the spinal cord. But nerve damage can flip this system into a hyperactive engine for chronic pain.

ObjectiveThis study aimed to investigate the associations between serum inflammatory mediators and chronic pain after laparoscopic inguinal hernia repair in elderly patients.MethodsFrom March 2022 to June 2023, 116 elderly patients (≥65 years old) diagnosed with inguinal hernia were enrolled in this study. All patients underwent total extraperitoneal repair (TEP) by laparoscopic surgery. Blood sa…

People with long-lasting low back pain may have a new evidence-based exercise option. Researchers in Australia have shown that a personalized swimming program can reduce pain and improve daily function better than education alone. Their findings were published in the British Journal of Sports Medicine. Low back pain is extremely common and is one of […] The post Could Swimming Be the Best Exercis…

Living with chronic migraine can be exhausting. People with this condition may experience severe headaches on many days each month, often together with nausea, vomiting, sensitivity to light and sound, and visual disturbances known as aura. These repeated attacks can greatly reduce quality of life and make it difficult to work, study, or care for […] The post Can Ear Stimulation Help Manage Chron…

As the travel season hits its peak, millions are preparing to spend hours on planes, trains, and in cars.

The takeaway: A CU Anschutz-led review examined whether spinal cord stimulation can help manage chronic pain in people with spinal cord injuries. Researchers found only 10 eligible studies involving 43 patients, but many participants reported substantial reductions in pain, along with improvements in sleep and quality of life. Because the available evidence is limited and based largely on small c…

Acta Pharmacologica Sinica, Published online: 16 June 2026; doi:10.1038/s41401-026-01849-y DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice

Kidney360. 2026 Jun 2. doi: 10.34067/KID.0000001198. Online ahead of print. ABSTRACT BACKGROUND: Legalization of cannabis across several US states may increase its use by individuals on hemodialysis, particularly among those with chronic pain. Contemporary data on frequency or factors associated with cannabis use by this population are limited. METHODS: We conducted a secondary analysis of […]

For millions battling chronic nerve pain, even the softest touch can feel agonizing — but scientists may have uncovered a radically new way to stop it at the source. Researchers at Duke University found that damaged nerves can be revived by supplying them with healthy mitochondria, the tiny energy producers inside cells.

A new study finds that an interdisciplinary, individualized approach to pain management, including coaching support and health goal planning, may reduce the impact of chronic pain on veterans. The findings were published in the journal JAMA.

Chronic pain affects hundreds of millions worldwide, yet current treatments—from NSAIDs to opioids—fall short and bring unwanted side effects. Neuroinflammation drives bidirectional glial-neuronal communication, a core mechanism underlying central sensitization in chronic pain, with chemokines serving as key mediators. Most studies to date have zeroed in on isolated pathways or specific anatomica…

Chronic pain is a long-lasting condition that affects nearly one in four adults. It is usually defined as pain that continues for more than three months. For many people, it becomes part of daily life and can limit what they are able to do. While doctors often focus on physical causes, there is growing evidence […] The post Emotional awareness can shape how people live with chronic pain appeared …

Chronic pain is sustained by coupled neuronal hyperexcitability and neuroinflammation, yet prevailing frameworks incompletely explain why similar injuries diverge toward recovery or persistent sensitisation. Growing evidence indicates that lactate, succinate and itaconate act as signalling metabolites that shape glial state transitions and nociceptive circuit gain. Here, we synthesise preclinical…

Back pain is a problem that many people experience at some point in their lives. For some, the pain goes away after a short time. But for others, it becomes a long-lasting condition that affects daily activities and overall quality of life. Chronic low back pain is especially difficult because it often has no clear […] The post How a bone hormone could help stop long-term back pain appeared first…

Researchers have identified a bone-driven signaling pathway that may explain how spinal degeneration leads to chronic pain. Low back pain (LBP) ranks among the most widespread health conditions across the globe. It affects people at every stage of life and creates a significant strain on healthcare systems. For many individuals, the pain becomes long-lasting, disrupting [...]

Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation, and rising hypertension risk.

Parenting with Chronic Pain Living with chronic pain is challenging–and parenting with chronic pain is a challenge that feels like it comes with little support. Parenting can already feel like driving somewhere new without a map–when you add in managing chronic pain on top of that, it can be hard to find resources that speak to your experience. There are a lot of limitations that come with experi…

3 Tips for Parenting a Child with Chronic Pain It can be challenging to parent a child with chronic pain. Not only is it difficult to see your child in pain, but parents often feel helpless, stuck, and unsure of what to do to help ease the pain and mitigate its impacts on their child’s life and daily functioning. For instance, children with chronic pain often begin to miss school, become socially…