chronic-pain

Chronic pain affects hundreds of millions worldwide, yet current treatments—from NSAIDs to opioids—fall short and bring unwanted side effects. Neuroinflammation drives bidirectional glial-neuronal communication, a core mechanism underlying central sensitization in chronic pain, with chemokines serving as key mediators. Most studies to date have zeroed in on isolated pathways or specific anatomica…

Chronic pain is a long-lasting condition that affects nearly one in four adults. It is usually defined as pain that continues for more than three months. For many people, it becomes part of daily life and can limit what they are able to do. While doctors often focus on physical causes, there is growing evidence […] The post Emotional awareness can shape how people live with chronic pain appeared …

Chronic pain is sustained by coupled neuronal hyperexcitability and neuroinflammation, yet prevailing frameworks incompletely explain why similar injuries diverge toward recovery or persistent sensitisation. Growing evidence indicates that lactate, succinate and itaconate act as signalling metabolites that shape glial state transitions and nociceptive circuit gain. Here, we synthesise preclinical…

Back pain is a problem that many people experience at some point in their lives. For some, the pain goes away after a short time. But for others, it becomes a long-lasting condition that affects daily activities and overall quality of life. Chronic low back pain is especially difficult because it often has no clear […] The post How a bone hormone could help stop long-term back pain appeared first…

Researchers have identified a bone-driven signaling pathway that may explain how spinal degeneration leads to chronic pain. Low back pain (LBP) ranks among the most widespread health conditions across the globe. It affects people at every stage of life and creates a significant strain on healthcare systems. For many individuals, the pain becomes long-lasting, disrupting [...]

Chronic pain doesn’t have to control your life. In It Doesn’t Have to Hurt, Sanjay Gupta explains how chronic pain develops when multiple body systems malfunction together, and why standard medical treatments often fall short. He argues that effective pain management requires a holistic, personalized approach combining physical and mind-body treatments. Gupta draws on his experience treating comp…

Parenting with Chronic Pain Living with chronic pain is challenging–and parenting with chronic pain is a challenge that feels like it comes with little support. Parenting can already feel like driving somewhere new without a map–when you add in managing chronic pain on top of that, it can be hard to find resources that speak to your experience. There are a lot of limitations that come with experi…

Individual experiences of chronic pain vary significantly. They can range from distracting or mildly annoying to completely debilitating. Chronic pain is a complex ailment that is often, but not always, a symptom of another condition. Those who live with chronic pain often find that it affects several aspects of their health and well-being.  Chronic pain […] The post Coach Resource: Holistic Appr…

3 Tips for Parenting a Child with Chronic Pain It can be challenging to parent a child with chronic pain. Not only is it difficult to see your child in pain, but parents often feel helpless, stuck, and unsure of what to do to help ease the pain and mitigate its impacts on their child’s life and daily functioning. For instance, children with chronic pain often begin to miss school, become socially…