Department of Medicine

Laura Mike, PhD, and Saroj Khadka are uncovering how Klebsiella pneumoniae senses its surroundings and adjusts its slimy exterior—a response that may influence where the pathogen thrives and how it causes disease.

Psychiatr Serv. 2026 Aug 6. doi: 10.1176/appi.ps.20250157. Online ahead of print. ABSTRACT OBJECTIVE: The COVID-19 pandemic exacerbated health disparities and increased alcohol use and its health consequences. Although prepandemic research identified racial and ethnic disparities in receipt of alcohol use disorder treatment, few studies have described postpandemic disparities or have assessed the…

John C. Byrd, MD, discusses the personal experiences that shaped his career, his vision for UPMC Hillman Cancer Center, and how expanding access, accelerating discovery, and strengthening clinical trials will transform cancer care in a recent UPMC Health Discovery Report Leadership Spotlight.

Am J Prev Med. 2026 Jul 30:108537. doi: 10.1016/j.amepre.2026.108537. Online ahead of print. ABSTRACT INTRODUCTION: A 2019 Medicare opioid safety policy limited initial opioid duration to 7 days and long-term daily dosage to 90 morphine milligram equivalence (MME). Because effective pain management may vary by rurality, this study examined whether the policy differentially affected opioid […]

J Pain. 2026 Jul 29:106313. doi: 10.1016/j.jpain.2026.106313. Online ahead of print. ABSTRACT The aims of this study were to characterize symptom clusters and examine the influence of social determinants of health (SDOH) on symptom cluster membership among people receiving maintenance hemodialysis and experiencing chronic pain. This study utilized baseline data collected from the 643 patients […]

Hosp Pediatr. 2026 Jul 17:e2025009094. doi: 10.1542/hpeds.2025-009094. Online ahead of print. ABSTRACT BACKGROUND: Illicitly manufactured fentanyl (IMF) is the predominant opioid in the US drug supply and is a major contributor to morbidity and mortality during pregnancy. While prenatal opioid exposure is an established risk factor for neonatal opioid withdrawal syndrome (NOWS), the differential …

JAMA Netw Open. 2026 Jul 1;9(7):e2623280. doi: 10.1001/jamanetworkopen.2026.23280. ABSTRACT IMPORTANCE: Buprenorphine-naloxone and extended-release (XR) naltrexone are both efficacious medications for opioid use disorder that reduce unregulated opioid use and improve opioid cravings and treatment retention. While prior comparative effectiveness studies demonstrated superiority of buprenorphine-na…

Subst Use Addctn J. 2026 Jul 10:29767342261463988. doi: 10.1177/29767342261463988. Online ahead of print. ABSTRACT BACKGROUND: Opioid treatment programs (OTPs), the only outpatient settings authorized to dispense methadone for opioid use disorder in the United States, often operate within compliance-focused frameworks that do not reflect the complex realities of substance use or the needs of many…

BMJ Qual Saf. 2026 Jul 7:bmjqs-2025-019297. doi: 10.1136/bmjqs-2025-019297. Online ahead of print. ABSTRACT INTRODUCTION: Physician burnout is related to patient safety and quality of care. Female physicians face unique challenges which may contribute to higher physician task load (PTL). We investigated the association of gender and PTL, and if gender differences in PTL contribute to […]

Subst Abuse Treat Prev Policy. 2026 Jul 3. doi: 10.1186/s13011-026-00746-1. Online ahead of print. ABSTRACT BACKGROUND: The evolving U.S. drug market has fueled a public health crisis with rising drug use-associated morbidity and mortality, revealing a mismatch between current abstinence-based addiction care and the needs of people who use drugs (PWUD) to access evidence-based harm […]

Harm Reduct J. 2026 Jul 1. doi: 10.1186/s12954-026-01492-0. Online ahead of print. ABSTRACT INTRODUCTION: People who use drugs (PWUD) in the U.S. often face barriers to accessing harm reduction, social, and medical services, including fragmented systems and limited access to locally relevant, usable information. A digital harm reduction support tool (DHRST) that identifies clients’ needs […]

Am J Ind Med. 2026 Jun 28. doi: 10.1002/ajim.70108. Online ahead of print. ABSTRACT BACKGROUND: Rideshare driving has become a common occupation within the emerging gig and platform economies. Despite offering a high degree of scheduling flexibility, rideshare driving provides little employment stability, an unstable income, and minimal employment benefits. This precarity, combined with the […]

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