metabolomics

Chronic pain is sustained by coupled neuronal hyperexcitability and neuroinflammation, yet prevailing frameworks incompletely explain why similar injuries diverge toward recovery or persistent sensitisation. Growing evidence indicates that lactate, succinate and itaconate act as signalling metabolites that shape glial state transitions and nociceptive circuit gain. Here, we synthesise preclinical…

IntroductionMetabolic reprogramming is a central driver of malignant progression in non-small cell lung cancer (NSCLC). However, conventional targeted therapies face significant limitations due to drug resistance and narrow therapeutic windows. Triptolide, a natural tricyclic diterpenoid derived from Tripterygium wilfordii, exhibits potent antitumor activity, yet its precise mechanisms for modula…

Deciphering metabolism with Sandrien Desmet Exploring metabolomics with Sandrien Desmet of the VIB Metabolomics Core Ghent Every second, countless chemical reactions power the processes that keep us alive. From breaking down food for energy to detoxifying harmful substances, our cells are constantly producing and using tiny molecules called metabolites. These metabolites are the byproducts of met…