Xylaria papulis Lloyd, an endophytic fungus, was isolated from the stem of Andrographis paniculata Willd., commonly known as green chiretta, which is native to India and Sri Lanka. To date, no report is available on the epigenetic modulation of X. papulis using the histone methyltransferase inhibitor UNC1999. Hence, this study aims to evaluate the independent effect of this probe. The fungal cult…
Cognitive neuroscience has made substantial progress in mapping neural activity underlying perception, memory, and decision-making. However, widely used methods such as functional magnetic resonance imaging and electrophysiology primarily measure indirect physiological correlates of neuronal activity and provide limited access to the biochemical processes that support neural signaling. In this re…
Chronic pain is sustained by coupled neuronal hyperexcitability and neuroinflammation, yet prevailing frameworks incompletely explain why similar injuries diverge toward recovery or persistent sensitisation. Growing evidence indicates that lactate, succinate and itaconate act as signalling metabolites that shape glial state transitions and nociceptive circuit gain. Here, we synthesise preclinical…
IntroductionMetabolic reprogramming is a central driver of malignant progression in non-small cell lung cancer (NSCLC). However, conventional targeted therapies face significant limitations due to drug resistance and narrow therapeutic windows. Triptolide, a natural tricyclic diterpenoid derived from Tripterygium wilfordii, exhibits potent antitumor activity, yet its precise mechanisms for modula…
Deciphering metabolism with Sandrien Desmet
Exploring metabolomics with Sandrien Desmet of the VIB Metabolomics Core Ghent
Every second, countless chemical reactions power the processes that keep us alive. From breaking down food for energy to detoxifying harmful substances, our cells are constantly producing and using tiny molecules called metabolites. These metabolites are the byproducts of met…
