Frontiers in Human Neuroscience | New and Recent Articles

Multisensory integration differences have been reported in individuals with Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD), yet little is known about how these traits may jointly influence multisensory processing. Given the high comorbidity between ASD and ADHD, examining their individual and combined effects is critical for understanding sensory integration in…

IntroductionBreast cancer brain metastases (BCBMs) represent a severe neurological complication affecting 10–20% of patients with metastatic breast cancer, with significant implications for treatment planning and prognosis. Accurate determination of hormone receptor (HR) status is critical for guiding personalized therapeutic strategies. However, traditional biopsy-based assessment is invasive, c…

Working memory (WM) is a core cognitive function that is both mechanistically tractable and clinically relevant, making it a prime target for noninvasive neuromodulation. However, transcranial magnetic stimulation (TMS) studies targeting the dorsolateral prefrontal cortex (DLPFC) have yielded variable WM outcomes, possibly because single-site protocols fail to engage the distributed network dynam…

Background/aimsTranscranial direct current stimulation (tDCS) has emerged as a promising intervention in both rehabilitation and cognitive enhancement, yet its effects remain inconsistent across studies. This variability has raised questions about the underlying mechanisms influencing tDCS efficacy.MethodsIn this review, we address the issue of the inconsistent effect of tDCS on motor and cogniti…

BackgroundDepression is common among elective lumbar spine surgery candidates and is associated with worse postoperative outcomes. Home-based transcranial direct current stimulation (tDCS) has demonstrated safety and feasibility, with evidence of antidepressant effects in remote randomized and open-label studies of major depressive disorder (MDD). Whether this approach can be feasibly and accepta…

IntroductionPeripheral nerve conduction parameters vary between individuals and may reflect differences in peripheral neurophysiological function. This exploratory observational study examined whether ulnar nerve conduction measures and reaction time were associated with academic indicators among male medical students. The study was designed to provide preliminary evidence regarding possible asso…

This study developed a novel, fully reproducible EEG-based framework for binary emotion recognition that combines phase-space reconstruction with Poincaré sections to capture the nonlinear dynamics of brain activity during prototypical emotional states. The method was applied to the publicly available AMIGOS dataset. EEG recordings from 33 participants were downsampled to 128 Hz, bandpass-filtere…

ObjectiveThis study focuses on patients with spinal cord injury (SCI), using healthy subjects as controls, and employs functional near-infrared spectroscopy (fNIRS) to compare the strength of resting-state functional connectivity (rsFC) between SCI patients and healthy subjects, providing neuroimaging evidence for the neuropathological mechanisms of sensory-motor dysfunction and other functional …

BackgroundAdolescent depression, characterized by high incidence rates and significant recurrence risks, has emerged as a major global public health concern. Current diagnosis relies predominantly on subjective questionnaires, lacking objective biomarkers and presenting challenges for early identification. Although exercise intervention is recommended as a safe and effective first-line non-pharma…

ObjectiveTo evaluate the feasibility of using the acoustic change complex (ACC) as an objective cortical marker of continuous speech sound discrimination using connected Ling-six stimuli.DesignCortical auditory evoked potentials were recorded from 10 young adults with normal hearing using a continuous, pause-free sequence of the six Ling phonemes (/u-a-i-ʃ-s-m/). ACC responses were recorded in a …

BackgroundDespite the growing interest in functional near-infrared spectroscopy (fNIRS) for practical brain-computer interface (BCI) applications, prefrontal hemodynamic responses during rapid serial visual presentation (RSVP) tasks remain poorly characterized, even though these tasks demand sustained attentional engagement under fast-paced visual streams.MethodsWe examined prefrontal cortex (PFC…

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and multifaceted neuropathology. Although fluid biomarkers cerebrospinal fluid (CSF) amyloid-β and tau and imaging biomarkers positron emission tomography (PET) have substantially advanced AD diagnostics, electroencephalography (EEG) remains a comparatively underutilized tool despite its unique…

IntroductionThe mental fatigue state of subway drivers directly affects operational safety. At the same time, they are easily influenced by individual emotions and are closely related to the state of brain function.MethodsIn this study, multimodal data of subway drivers during driving were collected synchronously in a simulated driving environment, including EEG signals, subjective fatigue percep…

IntroductionMilitary service members (SMs) often experience vestibular dysfunction, including symptoms like dizziness and gaze instability, following mild traumatic brain injury (mTBI). These impairments compromise their ability to perform military duties, emphasizing the necessity for effective rehabilitation strategies. We previously developed a mixed reality-based system, called RehabXR, to de…

Animals detect changes in the surrounding situation and predict what is likely to happen next by evaluating the current sensory information to that of a prior associative memory. Using working memory with inner speech, humans are able to flexibly predict the future situation and devise appropriate strategies to avoid dangers or achieve goals. This prospective thinking is supported not only by fee…

IntroductionSpinal cord injury (SCI) results in severe autonomic dysfunction, across cardiovascular, bladder, bowel and sexual domains, negatively affecting quality of life. Recently, there has been growing interest in the application of spinal cord stimulation (SCS) to restore or modulate autonomic functions in people with SCI. This review systematically evaluated the evidence for spinal cord an…

Developmental Coordination Disorder (DCD) should be considered as a multifaceted neurodevelopmental disorder characterized by extensive cerebral structural, functional, and connectivity patterns. DCD is commonly associated with other developmental conditions, including attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities (LD), speech-language dela…