pain

Musculoskeletal pain can begin or extend into the time period following childbirth, making it important to find a solution.

IntroductionCyclin-dependent kinase 5 (Cdk5) plays a critical role in pain transmission by phosphorylating key nociceptive proteins. One of its recently identified substrates, the P2X2 subunit, is part of the P2X2/3 purinergic receptor (P2X2/3R), which is implicated in nociceptive signaling. However, the specific contribution of Cdk5 to purinergic receptor-mediated pain responses remains unclear.…

ObjectiveThis study aimed to observe the clinical efficacy of multi-target high-frequency repetitive transcranial magnetic stimulation (rTMS) combined with acupuncture for chronic central post-stroke pain (CPSP) and emotional comorbidities during the recovery phase.MethodsThirty patients with CPSP admitted to the Rehabilitation Department of Hubei Third People’s Hospital from June 2024 to June 20…

BackgroundChronic pain following nerve injury (neuropathic pain), is notoriously difficult to treat, with current analgesics showing limited efficacy and adverse or dangerous side effects. One new candidate analgesic target is the TRPM8 ion channel, identified as the peripheral detector for innocuous cool sensation and reported to attenuate spinal cord pain processing by processes involving inhib…

Dr. Sanjay Gupta explains what we do — and still don't — know about pain When neurosurgeon and journalist Dr. Sanjay Gupta set out to write a book about pain, it wasn't because he felt like he had all the answers. It was because he was still so often mystified by it. Life Kit Dr. Sanjay Gupta wants to reframe your understanding of pain "Most of my patients come to me for pain. Head pain, back pai…

Chronic nerve pain is one of the most difficult health problems to treat. It affects millions of people around the world and can last for months or even years. This type of pain, also known as neuropathic pain, happens when nerves outside the brain and spinal cord are damaged. People often describe it as burning, […] The post New pain drug may relieve nerve pain without addiction risk, study find…

Back pain is a problem that many people experience at some point in their lives. For some, the pain goes away after a short time. But for others, it becomes a long-lasting condition that affects daily activities and overall quality of life. Chronic low back pain is especially difficult because it often has no clear […] The post How a bone hormone could help stop long-term back pain appeared first…

New study links testosterone-tuned monocytes to an anti-pain signal after injury.

Chronic pain lasts longer for women than men. New research suggests differences in immune cells called monocytes may help explain why.

Researchers have identified a bone-driven signaling pathway that may explain how spinal degeneration leads to chronic pain. Low back pain (LBP) ranks among the most widespread health conditions across the globe. It affects people at every stage of life and creates a significant strain on healthcare systems. For many individuals, the pain becomes long-lasting, disrupting [...]

A new book by pain researcher Rachel Zoffness demystifies how pain is made and how it can be treated.

"The idea was that blocking inflammation would reduce pain overall. "Instead, blocking inflammation increased pain in the long run."

Pain and sleep disturbances often go hand in hand — more than 30% of the U.S. population lives with pain, and a majority of those with pain also report sleep disorders — but the relationship between the two has remained largely unexplored. Now researchers at WashU Medicine have developed a new mouse model that mirrors […]

The research studies are testing low-intensity focused ultrasound neuromodulation for treating tobacco use disorder, opiate use disorder, and chronic pain.

Traumatic stress exposures (TSE) are common in life. While most individuals recover following a TSE, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae such as chronic posttraumatic musculoskeletal pain (CPMP). Vulnerability factors for CPMP are poorly understood, which hinders identification of high-risk individuals for targeted interventions. One known vulnerability fa…

A new explanation for why some people are in long-term pain says it could be caused by the immune system attacking the person's nerves

A hair pull is detected by a protein used to sense light touches. It also travels faster than most other types of pain.

Within a few days of injury, scientists can predict which patients will develop chronic pain based on the extent of cross "talk" between two regions of the brain, and the person’s anxiety level after the injury, according to a new Northwestern study. The post Chronic Pain Can Be Predicted Within Three Days of an Injury appeared first on News Center .

Today, more than 50 million adults in the U.S. suffer from chronic pain — pain lasting longer than three months — and is the most common reason why people seek medical attention, according to the Centers for Disease Control and Prevention (CDC). The post Advancing our Understanding Behind the Mechanisms of Pain appeared first on News Center .

Unraveling the Mystery of Migraines Carlene Moore’s infectious, bellowing laugh helps offset the serious nature of the work underway in her lab at Duke University School of Medicine to study painful conditions -- from sunburn and migraines to trigeminal neuralgia, a severe facial condition so painful it is known as the “suicide disease.” Moore, an assistant professor in neurology and member of th…