Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice

Nature Communications, Published online: 14 July 2026; doi:10.1038/s41467-026-75423-9 The authors find that netrin-1 secreted by endplate osteoclasts induces a cascade of netrin1/DCC downstream signaling in the dorsal horn synapses to generate nociplasticity for chronic low back pain in male mice.