Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain
Cristian G. Acosta
BackgroundThe renin–angiotensin system (RAS) contributes to inflammatory and neuropathic pain, but whether its primary receptors, AT1R and AT2R, regulate the K2P channel TWIK1 in sensory neurons remains unknown. We investigated whether Ang-II receptors modulate TWIK1 expression and whether this pathway influences neuropathic pain.MethodsAdult female rats underwent chronic constriction injury (CCI) of the sciatic nerve and received continuous subcutaneous administration of vehicle, telmisartan (A