plant-molecular-biology-research

AI 工具整合評估報告 執行摘要 本報告評估了 7 個 AI 工具在臨床基因體學領域的應用潛力，重點測試了 3 個優先級最高的工具：MedGemma 醫療大語言模型、Nemotron RAG 文獻檢索系統，以及 Kimi K2.5 多模態視覺語言模型。 評估日期 : 2026-02-10 測試平台 : RTX 3090 24GB 評估目標 : 確認 AI 工具在變異解釋與臨床決策中的可行性 1. 測試項目總覽 1.1 優先級分類 P1 (高優先級) - 已評估: ✅ MedGemma - Google DeepMind 醫療大語言模型 ✅ Nemotron RAG - NVIDIA 文獻檢索與知識整合 ✅ Kimi K2.5 - 月之暗面多模態視覺語言模型 P2 (中優先級) - 已規劃: 📋 Gemini CLI Hooks - 工作流自動化 📋 DaGGR - Hugging Fac…

Introduction: Apoptosis resistance in non-small cell lung cancer is frequently sustained by pro-survival Bcl-2 family proteins such as Mcl-1, motivating the search for new Mcl-1 inhibitors from natural products, including diterpenoids from Rabdosia serra . Materials and Methods: An integrated in silico approach was applied to evaluate R. serra diterpenoids as putative Mcl-1 (PDB: 6QFQ) inhibitors…

Scientists have uploaded a viral genome to a quantum computer, marking an important step for the future of quantum-enabled advancements in biology.

Antimicrobial resistance (AMR) represents a critical and escalating threat to global health, driven not only by microbial evolution but also by fundamental limitations in the pharmacokinetic and spatial delivery of antimicrobial agents in vivo. Conventional antibiotics exhibit non-specific systemic distribution, frequently fail to achieve sustained therapeutic concentrations at infection sites, a…

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74304-5 Functional genomics in algae are limited by efficient methods that connect genotype and metabolic phenotype at single-cell resolution. Here the authors introduce an approach based on a genome-wide mutant library and a Raman Cytometer, discovering a carotenoid synthesis regulating pathway.

Origami masters turn simple sheets of paper into ornate sculptures. In the origami of life, our cells must fold proteins into specific three-dimensional shapes before they can carry out their biological jobs.

Origami masters turn simple sheets of paper into ornate sculptures. In the origami of life, our cells must fold proteins into specific three-dimensional shapes before they can carry out their biological jobs. This folding process goes awry as prediabetes progresses into diabetes. Scientists at Sanford Burnham Prebys Medical Discovery Institute and the University of Michigan published findings Jun…

Researchers at Washington University have genetically engineered hookworms to produce and secrete a human antibody, creating a “living pharmaceutical biofactory,” according to the study published in Nature Communications.  To survive within the human gut, hookworms secrete over 800 molecules to modulate inflammation and maintain homeostasis.  “We thought: what if we make it secrete one more… The …

Microbiology dominated the research schedule aboard the International Space Station on Thursday helping doctors protect health on Earth and in space. The Expedition 74 crew also tested a new spacesuit, packed a U.S. cargo spacecraft, and kept up lab maintenance throughout the orbital outpost. The post Microbiology DNA and Chemistry for Health Insights Tops Research Schedule appeared first on NASA…

Collagen, the protein that builds skin, bones, tendons and organs, exists inside cells as a liquid-like droplet rather than the long, rigid rod seen in textbooks over the last half century, according to a new study from the Centre for Genomic Regulation (CRG) in Barcelona.

Researchers at the University of California San Diego have completed a massive genetic study that identifies key biological drivers of cocaine addiction, uncovering a potential new target for treatment that resides in the liver rather than the brain.

A new Northwestern Medicine study has demonstrated that proteins studied in simplified laboratory conditions don’t behave the same way in the human body, according to the study published in Nature Structural and Molecular Biology. The post Physiological Factors Reshape How Drugs and Proteins Interact appeared first on News Center .

Nature Communications, Published online: 11 June 2026; doi:10.1038/s41467-026-74085-x Human LARS1 senses leucine to activate mTORC1, but its dissociation mechanism from the MSC remains unclear. Here the authors determine the cryo-EM structure of the LARS1–IARS1 complex, revealing phosphorylation as a switch regulating LARS1 dissociation and mTORC1 activation.

RNA therapeutics have emerged as one of the most promising new classes of medicines. Eight small interfering RNA (siRNA) drugs have already been approved worldwide for the treatment of genetic diseases, yet scientists have not fully understood one of the most fundamental steps underlying their function: how Argonaute, the core protein responsible for gene silencing, becomes activated.

Background A 27-year-old male with perinatal hypoxia presented with global developmental delay, progressive hearing loss, ataxia, dysarthria, and intellectual disability. Whole-exome sequencing revealed compound heterozygous ACAD9 variants: c.456del (p.Ile153Serfs*46) and c.869G > A (p.Gly290Glu). Brain MRI showed bilateral cerebellar atrophy and a prominent cisterna magna. OCT confirmed optic at…

Scientific Data, Published online: 11 June 2026; doi:10.1038/s41597-026-07602-8 Complete NMR assignment for 275 of the most common dipeptides in intrinsically disordered proteins