Frontiers in Pharmacology | Neuropharmacology section | New and Recent Articles

Dravet syndrome (DS), caused by loss-of-function variants in SCN1A, is classically aggravated by chronic sodium-channel blocker treatment, reflecting impaired interneuron excitability as a core disease mechanism. Cenobamate (CNB) challenges this: adult DS cases with substantial seizure reduction have been reported, while pediatric experience is mixed and includes a small cohort with no responders…

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by relentless cognitive decline. Despite decades of research dominated by the amyloid and tau hypotheses, clinical interventions targeting these classical hallmarks have yielded limited success in halting disease progression, underscoring a critical conceptual and therapeutic gap: the early, persistent, and under-a…

IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and pervasive cognitive decline. Bavachinin, a natural flavonoid derived from the traditional medicinal herb Psoralea corylifolia, has previously been demonstrated to inhibit Aβ aggregation in vitro. However, its potential to alleviate cognitive impairment, …

Growing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular levels. The endocannabinoid system has emerged as a key regulator of brain homeostasis during aging, interfacing with neuroinflammation, neurogenesis, and blood–brain barrier integrity. However, the neurological impact of exogenous cannabinoids in the aging brain …

Despite the knowledge of the health risks of smoking, exposure to nicotine leads to smoking habits. Clarifying the neuronal mechanism of smoking preference formation underlying the development of smoking habits has a great impact on the establishment of effective smoking cessation therapies. In this study, the brain regions that determine the preference for oral nicotine intake in the two-bottle …

While glia-derived exosomes have been extensively studied in heatstroke induced brain injury, the role of exosomal microRNAs (miRNAs) secreted by astrocyte remains underexplored. In this study, the viability of C8-D1A cells decreased after heat stress, apoptosis rate and the expression levels of proinflammatory cytokines such as TNF-α, IL-6, IL-1α and IL-1β increased to different degrees. The ext…

BackgroundSocial isolation (SI) is a long-standing experimental paradigm that models schizophrenia-like behavioural and neurobiological changes caused by the action of oxidative stress, neuroinflammation, apoptosis, and neurotransmitter imbalance. The scope of this paper was to comparatively assess the effectiveness of rutin, sodium selenite (Na2SeO3), and rutin-conjugated selenium nanoparticles …