Frontiers in Pharmacology | Neuropharmacology section | New and Recent Articles

Despite the knowledge of the health risks of smoking, exposure to nicotine leads to smoking habits. Clarifying the neuronal mechanism of smoking preference formation underlying the development of smoking habits has a great impact on the establishment of effective smoking cessation therapies. In this study, the brain regions that determine the preference for oral nicotine intake in the two-bottle …

While glia-derived exosomes have been extensively studied in heatstroke induced brain injury, the role of exosomal microRNAs (miRNAs) secreted by astrocyte remains underexplored. In this study, the viability of C8-D1A cells decreased after heat stress, apoptosis rate and the expression levels of proinflammatory cytokines such as TNF-α, IL-6, IL-1α and IL-1β increased to different degrees. The ext…

BackgroundSocial isolation (SI) is a long-standing experimental paradigm that models schizophrenia-like behavioural and neurobiological changes caused by the action of oxidative stress, neuroinflammation, apoptosis, and neurotransmitter imbalance. The scope of this paper was to comparatively assess the effectiveness of rutin, sodium selenite (Na2SeO3), and rutin-conjugated selenium nanoparticles …