Neuroprotective effects of rutin, sodium selenite, and rutin-conjugated selenium nanoparticles in a social isolation model
Mohamed H. A. Gadelmawla
BackgroundSocial isolation (SI) is a long-standing experimental paradigm that models schizophrenia-like behavioural and neurobiological changes caused by the action of oxidative stress, neuroinflammation, apoptosis, and neurotransmitter imbalance. The scope of this paper was to comparatively assess the effectiveness of rutin, sodium selenite (Na2SeO3), and rutin-conjugated selenium nanoparticles (RUT-SeNPs) to determine their neuroprotective activity using a rat model of neurobehavioral impairme