IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and pervasive cognitive decline. Bavachinin, a natural flavonoid derived from the traditional medicinal herb Psoralea corylifolia, has previously been demonstrated to inhibit Aβ aggregation in vitro. However, its potential to alleviate cognitive impairment, restore large-scale brain network dysfunctions, and mitigate AD-related pathology in vivo remains elu