pediatric

IntroductionPostoperative rehabilitation exercise adherence is critical for recovery after pediatric kidney transplantation, yet its associated psychosocial factors remain insufficiently characterized. This study aimed to examine postoperative psychological status and rehabilitation exercise adherence in pediatric kidney transplant recipients, identify distinct adherence patterns, and determine a…

PurposeSpindle cell and sclerosing rhabdomyosarcoma (sRMS/scRMS) are rare variants accounting for 5%–10% of all RMS cases. This study aimed to evaluate the feasibility of using drug sensitivity assay to guide real time treatment decisions in children with sRMS/scRMS.MethodsWe retrospectively analyzed 14 consecutive patients diagnosed with sRMS/scRMS between January 2020 and December 2024. All pat…

Researchers are investigating a new way to tackle bone cancer while minimizing toxicity typically associated with chemotherapy.

Accurate prediction of busulfan exposure is critical to achieve target myeloablative exposure while minimizing toxicity in pediatric hematopoietic stem cell transplantation. Model-informed precision dosing is recommended for improved accuracy and flexibility; dose adjustments in clinical practice are frequently performed using linear proportionality between dose changes and area under the concent…

Background/objectivePsychotropic medications are often associated with significant and rapid weight gain in pediatric populations, especially second-generation antipsychotics and mood stabilizers. This was a retrospective study assessing weight gain, and tolerability of adjunctive topiramate in hospitalized child and adolescent psychiatric patients.MethodsA total of 285 inpatients were included i…

Pediatricians who participated in the collaborative mental health program at Ann & Robert H. Lurie Children's Hospital of Chicago were more likely to diagnose and treat anxiety and depression in kids without reliance on additional support from specialists, according to a study published in Academic Pediatrics.

Background Pediatric critical care medicine (PCCM) fellowship programs must meet established educational standards; however, interfacility transport opportunities vary across sites. Objective To query key stakeholders, is the interfacility transport medicine rotation still an important component of the PCCM fellowship? Methods A multi-methods questionnaire was sent to a convenience sample ( n = 6…

ImportanceOptimizing ADHD stimulant therapy in children is difficult due to individual variability and lack of reliable response predictors, forcing a trial-and-error approach that burdens both patients and families.ObjectiveTo identify factors associated with treatment success based on real-world patterns of ADHD stimulant use.DesignSetting and participants: In this retrospective cohort study we…

BackgroundInfliximab (IFX) is a chimeric monoclonal antibody against tumor necrosis factor-alpha (TNF-α) that is widely used for induction and maintenance therapy in pediatric inflammatory bowel disease (IBD), yet its effects on the developing intestinal microbiome and treatment response remain unclear.ObjectiveTo systematically synthesize evidence on IFX-associated microbiome changes in pediatri…

Dravet syndrome (DS), caused by loss-of-function variants in SCN1A, is classically aggravated by chronic sodium-channel blocker treatment, reflecting impaired interneuron excitability as a core disease mechanism. Cenobamate (CNB) challenges this: adult DS cases with substantial seizure reduction have been reported, while pediatric experience is mixed and includes a small cohort with no responders…

A cancer researcher at the University of Houston is reporting what makes malignant soft tissue cancer grow in children, identifying key mechanisms and molecular targets to prevent tumor progression in patients in future therapies of the fatal rhabdomyosarcoma.

Accidental ingestion of caustic substances can alter a child's life in an instant, damaging the esophagus and leaving lasting nutritional sequelae, respiratory complications, and psychosocial impairments. A new study shows that two major reconstructive options--colonic pedicled flap and gastric tube replacement--can both support satisfactory long-term recovery after severe pediatric caustic inju…

A first-of-its-kind study at Children's Hospital Los Angeles offers new insight into how an acute care cardiology model can improve care for pediatric patients.

Finding Cancer’s Weakness May 2026 PhD graduate Alan Wong focuses on developing new approaches to treat pediatric leukemia while reducing harm to the brain. Emily Crowell Tue, 04/21/2026 - 13:18

Investigators in the laboratory of Gemma Carvill, PhD, have discovered novel molecular underpinnings of Dravet syndrome, a rare genetic form of epilepsy in children, that may serve as promising therapeutic targets, according to a recent study. The post Uncovering New Therapeutic Targets for Pediatric Epilepsy appeared first on News Center .

A new wearable sensor that actually quantifies itch by measuring scratching when placed on the hand has been developed by Northwestern University scientists. The post Wearable Sensor Tracks Pediatric Eczema, Adult Itch Symptoms appeared first on News Center .