Growing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular levels. The endocannabinoid system has emerged as a key regulator of brain homeostasis during aging, interfacing with neuroinflammation, neurogenesis, and blood–brain barrier integrity. However, the neurological impact of exogenous cannabinoids in the aging brain remains incompletely defined and often polarized between neuroprotective and neurodisruptive interpre