sleep-disorders

BackgroundInsomnia and sleep disturbances are highly prevalent among healthcare professionals and pose risks to patient safety. Brain Dynamic Audio Stimulation (BDAS) is a non-invasive, open-loop auditory intervention intended to facilitate sleep initiation. This single-arm pilot feasibility study examined the feasibility and preliminary signal of a 14-day BDAS intervention in healthcare professi…

This is a narrative review aiming to summarize the latest research progress of orexin receptor antagonists in insomnia treatment. To review the latest research progress on orexin receptor antagonists in the treatment of sleep disorders and explore their potential in terms of drug safety, efficacy, addiction risk, and the treatment of insomnia comorbid with psychiatric and neurological disorders. …

The Food and Drug Administration just greenlit a medication called Orzeyful for the treatment of narcolepsy type 1 in adults. The condition is caused by the loss of brain cells that produce orexin, a chemical important for regulating the sleep-wake cycle

BackgroundThe relationship between sleep disorders and psychiatric disorders has been extensively studied in epidemiological research. However, whether specific sleep-related traits are associated with psychiatric disorders through potential causal mechanisms remains incompletely understood.MethodsThis study employed a two-sample Mendelian randomization (MR) analysis method to investigate potenti…

Poor sleep can affect almost every part of the body, including the hormones that keep us healthy. Researchers are increasingly finding that sleep disorders and hormone disorders often occur together. A new Brazilian study suggests that one of the strongest links may be between hypothyroidism and obstructive sleep apnea. Hypothyroidism develops when the thyroid gland […] The post Hidden Thyroid Pr…

Obstructive sleep apnea may affect more than the airway. By combining polysomnography with retinal imaging, we examined whether apnea severity is associated with retinal vascular fractal dimension and whether diabetes modifies this relationship.

According to a study conducted in Brazil by researchers at the Federal University of São Paulo (UNIFESP) with participants from the São Paulo Epidemiological Sleep Study (EPISONO 2018), people with hypothyroidism experience a higher frequency and severity of obstructive sleep apnea (OSA).

Anxiety and depressive disorders impose a heavy global burden. Although sleep disturbances have traditionally been regarded as secondary symptoms of these conditions, converging evidence now implicates circadian rhythm disruption as a core pathophysiological mechanism rather than a mere epiphenomenon. This review systematically explores the circadian system and constructs an integrated framework …

Insomnia disorder is one of the most common sleep disorders and is traditionally conceptualized in terms of hyperarousal, altered sleep homeostasis, and cognitive-behavioral perpetuating factors. The two-process model of sleep regulation indicates that sleep initiation and maintenance depend not only on homeostatic sleep pressure but also on circadian phase, amplitude, and stability. Evidence sug…

A rapid and accurate blood test has been developed that can measure melatonin in the blood in extremely small amounts. The method could open new possibilities, including sleep disorders, mental disorders and metabolic disorders. But the researchers emphasise that the clinical work has only just begun.

Many people think of snoring as little more than an annoyance, but for some people it may be a sign of a serious medical condition called obstructive sleep apnea. In this disorder, the muscles in the throat relax repeatedly during sleep, causing the airway to narrow or close. Breathing stops for short periods before the […] The post Sleep Apnea Linked to Poor Memory and Greater Dementia Risk appe…

ObjectiveSleep disorders represent a serious global health challenge. However, the role of major environmental exposures, such as high-altitude hypoxia, and how they modify the influence of established risk factors across populations with differing susceptibility, remains poorly understood. This study aims to investigate the association between metabolic markers and sleep disorders under various …

ObjectiveThis study aims to comprehensively analyze and evaluate the efficacy and safety of daridorexant in treating insomnia.MethodsThis study conducted a systematic search across 7 electronic databases: PubMed, Web of Science, Cochrane Library, Embase, ClinicalTrials.gov, Scopus and the World Health Organization International Clinical Trials Registry Platform [http://www.who.int/ictrp/search/en…

Although pharmacological treatments for insomnia remain widely prescribed, their long-term use is constrained by risks of tolerance, dependence, and residual daytime effects. This has prompted growing interest in non-pharmacological interventions that target insomnia’s underlying mechanisms. This narrative review examines five physical factor therapies for insomnia: auditory stimulation, photothe…

This JMCR case highlights a dramatic shift from mild obstructive sleep apnea at sea level to severe central sleep apnea at high altitude, refractory to CPAP and acetazolamide but successfully treated with CPAP plus supplemental oxygen.

Millions of people around the world struggle with obstructive sleep apnea, a serious sleep disorder that causes breathing to repeatedly stop and start during sleep. Many people with the condition snore loudly, wake up feeling exhausted, or feel sleepy during the day even after spending many hours in bed. In severe cases, sleep apnea can […] The post New Bedtime Pill May Treat Sleep Apnea Better a…

BackgroundSleep disorders represent a common and impactful complication following acute ischemic stroke (AIS). This study aimed to identify clinical risk factors and evaluate the predictive value of serum hypocretin (Hcrt), neurofilament heavy chain (NfH), and interleukin-1 beta (IL-1β) for post-stroke sleep disorders.MethodsWe conducted a retrospective observational study of 256 patients with AI…

ObjectiveThis study aimed to evaluate the effectiveness of pharyngeal musculature and genioglossus exercising as a postoperative rehabilitation intervention for patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) following uvulopalatopharyngoplasty (UPPP)—a setting with limited prior evidence.MethodsThis is a retrospective cohort study conducted in the first people’s Hospital of Linpi…

Melatonin is widely used across the world for children who have trouble sleeping. Learn about the recent research and guidelines for healthcare providers.

A study has revealed that a common sleep disorder may be affecting brain health more seriously than many people realize. Obstructive sleep apnea, often called OSA, is a condition that disrupts breathing during sleep. While it is widely known for causing loud snoring and poor sleep, new research suggests it can also harm thinking, memory, […] The post Common sleep problem could quietly damage your…