antibiotics

The emergence of drug-resistant porcine enterotoxigenic Escherichia coli (ETEC) necessitates the exploration of alternative antibacterial approaches. Two lytic bacteriophages, PES-1 and PES-2, have been isolated and characterized to control ETEC. PES-1 exhibited a wide host range, lysing five ETEC strains, whereas PES-2 displayed restricted specificity, impacting only one of the seven strains. Bo…

The Guide to Pharmacology have been collaborating with AntibioticDB (https://www.antibioticdb.com; ADB) since 2019, with the aim of extending the coverage of antibacterial compounds in GtoPdb and providing comprehensive chemistry and pharmacology for selected antibacterials curated with ADB. The collaboration has been supported more recently by the Global Antibiotic Research and Development Partn…

Antibiotics are essential tools in modern medicine. They treat bacterial infections by killing harmful bacteria or making it harder for them to grow and multiply.   Whether it be for […] Van Andel Institute - Van Andel Institute transforms human health through groundbreaking biomedical research and cutting-edge science education.

FEBRUARY 10, 2025 — Undergraduates at UTSA are tackling the growing antibiotic resistance crisis as part of a microbiology course studying soil samples. The U.S. Centers for Disease Control and Prevention describes antimicrobial resistance as “one of the world’s most urgent public health problems.” It occurs as pathogens develop defense mechanisms against common antibiotic medications. According …

While many scientists played pivotal roles in the antibiotic revolution and deserve celebration, some contributors remain overshadowed by others, which is the case for the story of streptomycin. Elizabeth Bugie Gregory, a microbiologist whose work was integral to discovering this life-saving antibiotic, is one such unsung hero. This article delves into her significant contributions and the histor…

Our global antibiotics-resistance challenge leads us to develop new strategies to fight resistant bacteria. While novel antibiotics are being developed, investigations should also focus on how to change the therapeutic approaches of currently used antibiotics. The study “Gram-negative bacteria act as a reservoir for aminoglycoside antibiotics that interact with host factors to enhance bacterial k…