Nature Reviews Drug Discovery

Nature Reviews Drug Discovery, Published online: 22 May 2026; doi:10.1038/d41573-026-00087-5 Incretin-based multi-agonist reverses obesity and diabetes

Nature Reviews Drug Discovery, Published online: 20 May 2026; doi:10.1038/d41573-026-00085-7 FDA approves first-in-class hypertension drug

Nature Reviews Drug Discovery, Published online: 20 May 2026; doi:10.1038/d41573-026-00084-8 Nobel laureate Shinya Yamanaka discusses the therapeutic and drug discovery applications for induced pluripotent stem cells.

Nature Reviews Drug Discovery, Published online: 19 May 2026; doi:10.1038/s41573-026-01442-2 Agonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and explains how recent mechanistic insights should broaden the scope and improve the safety and efficacy of …

Nature Reviews Drug Discovery, Published online: 18 May 2026; doi:10.1038/s41573-026-01449-9 Autophagy has a highly complex and context-dependent role in cancer, challenging the development of autophagy-modulating strategies. This Review discusses the potential of targeting autophagy to counteract malignant transformation, prevent disease progression and enable anticancer immunosurveillance. Exis…

Nature Reviews Drug Discovery, Published online: 13 May 2026; doi:10.1038/s41573-026-01427-1 Incretin-based therapies are transforming the treatment of obesity and related comorbidities. This Review outlines the current landscape of obesity drug development, focusing on glucagon-like peptide 1 receptor agonists, multi-receptor agonists, amylin receptor agonists and next-generation oral therapies.…

Nature Reviews Drug Discovery, Published online: 13 May 2026; doi:10.1038/d41573-026-00081-x Trends in the landscape of clinical trials of innovative drugs in China since 2015

Nature Reviews Drug Discovery, Published online: 12 May 2026; doi:10.1038/d41573-026-00080-y A peptide-guided strategy for kinase activation

Nature Reviews Drug Discovery, Published online: 11 May 2026; doi:10.1038/d41573-026-00079-5 Eli Lilly inks dual-payload ADCs deal

Nature Reviews Drug Discovery, Published online: 08 May 2026; doi:10.1038/d41573-026-00078-6 First PROTAC gains FDA approval, bolstering targeted protein degradation and induced proximity ambitions

Nature Reviews Drug Discovery, Published online: 08 May 2026; doi:10.1038/d41573-026-00077-7 The ovarian cancer drug market

Nature Reviews Drug Discovery, Published online: 06 May 2026; doi:10.1038/d41573-026-00074-w The potential for drug repurposing to provide faster, cost-effective ways to address unmet medical needs remains to be fully realized. Overcoming systemic challenges and promoting collaboration will be key for drug repurposing to contribute more to new treatments, especially for rare diseases.

Nature Reviews Drug Discovery, Published online: 06 May 2026; doi:10.1038/d41573-026-00067-9 Novel opioid provides cleaner pain relief

Nature Reviews Drug Discovery, Published online: 05 May 2026; doi:10.1038/d41573-026-00069-7 Katarzyna Smietana, Sebastian Kluger, Joao Mendes, Alberto Loche & Brandon Parry

Nature Reviews Drug Discovery, Published online: 01 May 2026; doi:10.1038/d41573-026-00075-9 Dual-vector gene therapy for hearing loss secures first FDA approval

Nature Reviews Drug Discovery, Published online: 01 May 2026; doi:10.1038/d41573-026-00076-8 First-in-class HIV drug nabs approval

Nature Reviews Drug Discovery, Published online: 01 May 2026; doi:10.1038/d41573-026-00063-z The landscape for therapeutic cancer vaccines

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/s41573-026-01411-9 Kinases represent one of the largest superfamilies of drug targets, but many members have remained notoriously challenging to drug by traditional small-molecule approaches. This Review assesses approaches and agents aimed at therapeutically modulating kinases, comparing orthosteric, allosteric and induc…

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/d41573-026-00072-y AhR inhibition promotes axon regeneration

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/d41573-026-00073-x IL-2-TGFβ co-agonist induces immune tolerance