Nature Reviews Drug Discovery

Nature Reviews Drug Discovery, Published online: 05 May 2026; doi:10.1038/d41573-026-00069-7 Katarzyna Smietana, Sebastian Kluger, Joao Mendes, Alberto Loche & Brandon Parry

Nature Reviews Drug Discovery, Published online: 01 May 2026; doi:10.1038/d41573-026-00075-9 Dual-vector gene therapy for hearing loss secures first FDA approval

Nature Reviews Drug Discovery, Published online: 01 May 2026; doi:10.1038/d41573-026-00076-8 First-in-class HIV drug nabs approval

Nature Reviews Drug Discovery, Published online: 01 May 2026; doi:10.1038/d41573-026-00063-z The landscape for therapeutic cancer vaccines

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/s41573-026-01411-9 Kinases represent one of the largest superfamilies of drug targets, but many members have remained notoriously challenging to drug by traditional small-molecule approaches. This Review assesses approaches and agents aimed at therapeutically modulating kinases, comparing orthosteric, allosteric and induc…

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/d41573-026-00072-y AhR inhibition promotes axon regeneration

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/d41573-026-00073-x IL-2-TGFβ co-agonist induces immune tolerance

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/d41573-026-00071-z Fast-acting covalent protein drugs

Nature Reviews Drug Discovery, Published online: 28 April 2026; doi:10.1038/d41573-026-00070-0 Remodelling complex macrocycles

Nature Reviews Drug Discovery, Published online: 27 April 2026; doi:10.1038/d41573-026-00068-8 In vivo CAR T purchase spree continues with Lilly deal worth up to US$7 billion

Nature Reviews Drug Discovery, Published online: 27 April 2026; doi:10.1038/s41573-026-01431-5 Ten years after the first FDA approval, CDK inhibition is entering a new phase in oncology. This Review examines how combination strategies, emerging CDK2- and CDK4-selective inhibitors, and developing biomarkers are reshaping the clinical use of CDK-targeted therapies and broadening their potential bey…

Nature Reviews Drug Discovery, Published online: 24 April 2026; doi:10.1038/d41573-026-00066-w Inhibiting the integrated stress response restores cognition

Nature Reviews Drug Discovery, Published online: 22 April 2026; doi:10.1038/d41573-026-00065-x Cell surface SRC flags tumours

Nature Reviews Drug Discovery, Published online: 17 April 2026; doi:10.1038/d41573-026-00062-0 Initial clinical data indicate that CAR-T cell therapies that deplete B cells could change the treatment paradigm in refractory B cell-driven autoimmune diseases. This article discusses key considerations in realizing the potential of such therapies.

Nature Reviews Drug Discovery, Published online: 16 April 2026; doi:10.1038/d41573-026-00061-1 FDA new drug approvals in Q1 2026

Nature Reviews Drug Discovery, Published online: 20 April 2026; doi:10.1038/s41573-026-01412-8 Artificial intelligence (AI) is playing an increasingly important role in drug target identification and assessment, based on its proficiency in analysing large datasets and biological networks. This article reviews advances in the application of AI-driven approaches for therapeutic target exploration, …

Nature Reviews Drug Discovery, Published online: 10 April 2026; doi:10.1038/d41573-026-00056-y Bioconjugated oligonucleotides (BCOs) promise to expand the applicability of RNA-based medicines. Here, we present recommendations for nonclinical safety strategies in advancing BCOs into the clinic.

Nature Reviews Drug Discovery, Published online: 15 April 2026; doi:10.1038/d41573-026-00060-2 Wendy Young, an advisor at Google Ventures and former head of small-molecule drug discovery at Genentech, discusses the dearth of women’s health drug discovery programmes.

Nature Reviews Drug Discovery, Published online: 20 April 2026; doi:10.1038/d41573-026-00064-y A handful of antibody-based extracellular targeted protein degraders are advancing in the clinic, highlighting emerging opportunities to destroy disease-linked proteins in cancer and autoimmunity.

Nature Reviews Drug Discovery, Published online: 07 April 2026; doi:10.1038/d41573-026-00058-w Lipid nanoparticles deliver to the pancreas