inflammatory-diseases

Nature Immunology, Published online: 18 June 2026; doi:10.1038/s41590-026-02546-y Regulatory T cells are responsible for suppressing inflammation, yet they fail to do so in rheumatoid arthritis. We show that signals in the local tissue environment can drive these cells into either protective or dysfunctional states.

A new study led by researchers at The University of Texas MD Anderson Cancer Center has uncovered a previously unknown connection between nucleic acid structures called R-loops and age-related inflammation – or inflammaging – that could herald new intervention options for chronic inflammation and the subsequent health conditions.

BackgroundAge-related macular degeneration (AMD) is a severe eye disease that affects the macula, the central area of the retina. Current treatment consists of intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors. However, some patients remain refractory to treatment even after maximal anti-VEGF dosage. We longitudinally analyzed angiogenic and inflammatory biomarkers i…

ObjectiveTo determine whether serum exosomal long non-coding RNA AC245100.4 has value for early diagnosis and prognostic stratification in acute pancreatitis (AP), and to examine its potential involvement in inflammation-related cellular communication.MethodsA total of 228 participants were enrolled during the early admission phase, including 152 patients with AP and 76 controls with non-pancreat…

Uveitis is an inflammatory ocular condition that primarily affects young adults and is often associated with systemic and autoimmune disorders. This disease primarily affects intraocular structures such as the iris, ciliary body, and choroid. Clinically, it manifests through a series of symptoms, including eye redness, pain, and blurred vision, which significantly impact the quality of life for p…

As people get older, many begin to worry about diseases such as Alzheimer’s, diabetes, and cancer. One common factor behind many of these conditions is something called chronic inflammation. Unlike short-term inflammation, which helps the body heal after injury or fight infection, chronic inflammation is harmful. It keeps the body in a constant state of […] The post Study finds how to “switch off…

Chronic inflammation is a hidden process in the body that can quietly damage health over time. Unlike short-term inflammation, which helps the body heal from injury or infection, chronic inflammation stays active for too long. This ongoing response can harm tissues and organs and has been linked to serious diseases such as Alzheimer’s disease, Parkinson’s […] The post Scientists discover ‘off swi…

Northwestern scientists have discovered how mitochondria influence the body’s immune response through modulating specific cell signaling pathways, according to a recent study published in Science Advances. The post Mitochondria May Be a Promising Therapeutic Target for Inflammatory Diseases appeared first on News Center .