Nature Immunology

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02568-6 Some patients with pyoderma gangrenosum harbor a mutation (R57C) in OTULIN that disrupts the interaction between OTULIN and LUBAC leading to hyperactivation in monocytes and enhanced susceptibility of keratinocytes to TNF-induced, caspase-dependent cell death. One patient treated with anti-TNF therapy showed clinica…

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02563-x Here, the authors conduct integrated multiomics analysis of B cell activation, differentiation and diversification responses to malaria infection and provide a graphical user interface for readers to mine these data.

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02569-5 This study compares the humoral response of individuals who received inactivated influenza vaccines to that of individuals who received an mRNA-based quadrivalent influenza vaccine. The mRNA-based vaccine induced prolonged germinal center responses, more antibodies and increased numbers of memory B cells.

Nature Immunology, Published online: 12 June 2026; doi:10.1038/s41590-026-02562-y The identification of an alveolar epithelial-like subset of medullary thymic epithelial cells (mTECs) reveals a key mechanism that orchestrates mTEC heterogeneity, thereby maintaining central immune tolerance.

Nature Immunology, Published online: 10 June 2026; doi:10.1038/s41590-026-02576-6 Retraction Note: Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells

Nature Immunology, Published online: 10 June 2026; doi:10.1038/s41590-026-02574-8 Author Correction: Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity

Nature Immunology, Published online: 08 June 2026; doi:10.1038/s41590-026-02542-2 Davidson et al. map the cellular and structural composition of developing joints and identify fibroblast populations that may predispose joints to inflammatory arthritis.

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02552-0 Fed T cells

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02550-2 Stromal immunology in Sjögren disease

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02553-z Affinity maturation of AAN-I-IFNs

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02551-1 OXPHOS fuels cDC1s

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02535-1 Sims, Farber and colleagues analyze T cells from lymphoid and mucosal tissues of infant and adult human organ donors to show that infant T cells have a unique stem-like transcriptional profile and tissue adaptation program.

Nature Immunology, Published online: 02 June 2026; doi:10.1038/s41590-026-02533-3 Our results show that the transcription factor RFX7 acts as a tumor suppressor in mouse models of B cell lymphoma. RFX7 limits the activity of MYC, a key regulator of B cell activation and lymphomagenesis. We also demonstrate that alterations of RFX7 found in lymphomas can substantially affect its transcriptional ac…

Nature Immunology, Published online: 01 June 2026; doi:10.1038/s41590-026-02572-w Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

Nature Immunology, Published online: 01 June 2026; doi:10.1038/s41590-026-02526-2 Guarda and colleagues investigate the role of the transcription factor RFX7 in B cell activation and lymphomagenesis. The findings indicate that Rfx7 regulates germinal center B cell, plasmablast generation and malignant transformation by restricting Myc activity.

Nature Immunology, Published online: 29 May 2026; doi:10.1038/s41590-026-02539-x In a shifting regulatory landscape that increasingly favors organ-on-chip and human cell-based systems, embedding immune complexity is essential to advance new approach methodologies beyond reductionist models and toward a hybrid ecosystem that integrates animal studies.

Nature Immunology, Published online: 26 May 2026; doi:10.1038/s41590-026-02531-5 Intercellular circuits between the myeloid compartment and T cells, keratinocytes and fibroblasts reveal how type I interferon (IFN) and sunlight drive photosensitive skin lesion development, with MMP9+CD14+ cells having a central role.

Nature Immunology, Published online: 25 May 2026; doi:10.1038/s41590-026-02536-0 Waterfield and colleagues report the transcription factor RUNX1 expressed in mTECs profoundly influences the diversity of thymic mimetic cells that express tissue-specific antigens.

Nature Immunology, Published online: 25 May 2026; doi:10.1038/s41590-026-02532-4 An amino acid metabolic enzyme transforms bacterial lipoproteins into disulfide-linked lipid structures that activate the non-canonical inflammasome, redefining cytosolic innate immune sensing as a process shaped by host metabolic remodeling.

Nature Immunology, Published online: 25 May 2026; doi:10.1038/s41590-026-02522-6 mRNA-based vaccines saved millions of lives during the COVID-19 pandemic, but they require frequent boosting and periodic updates to match emerging virus strains. We demonstrate that fungal glycans can function as adjuvants for mRNA-based vaccines, expanding the durability and breath of protection against several vir…