Nature Immunology

Nature Immunology, Published online: 21 August 2026; doi:10.1038/s41590-026-02616-1 In this Review, Hart and colleagues summarize some of the key cellular players and soluble mediators involved in idiopathic pulmonary fibrosis progression, and how distinct types of inflammation jointly regulate disease progression in concert rather than focusing on individual cytokines or immune cells.

Nature Immunology, Published online: 20 August 2026; doi:10.1038/s41590-026-02619-y Here, Brennan and colleagues report that chronic type 2 inflammation drives the differentiation of progenitor-like T helper 2 cells, distinct from acute and resting memory cells and with the capacity to sustain lung inflammation in the face of ongoing antigen exposure.

Nature Immunology, Published online: 20 August 2026; doi:10.1038/s41590-026-02627-y A population of intramucosal GPR15-guided regulatory CD8+ T cells control intestinal inflammation by inducing cell death in inflammatory macrophages.

Nature Immunology, Published online: 18 August 2026; doi:10.1038/s41590-026-02615-2 Here the authors create a syncytial chimeric antigen receptor (CAR) cell that fuses CAR macrophages with neutrophils, equipping these cells with the antitumor functions from both cell types.

Nature Immunology, Published online: 18 August 2026; doi:10.1038/s41590-026-02612-5 Microfold cells are known for ferrying gut antigens to immune cells to trigger antibody responses. We identify a second function for microfold cells in Peyer’s patches in establishing a spatial niche that positions group 3 innate lymphoid cells and sustains their production of the protective cytokine interleukin-2…

Nature Immunology, Published online: 18 August 2026; doi:10.1038/s41590-026-02618-z Huber-Lang et al. review the multidimensional immune response to trauma. The Review discusses innate and adaptive immunity across neuroendocrine, endovascular and metabolic axes in the setting of traumatic injury.

Nature Immunology, Published online: 18 August 2026; doi:10.1038/s41590-026-02624-1 High-throughput, high-dimensional profiling technologies have transformed the ability to generate and test hypotheses of human immunology. Investment in infrastructure has catalyzed the expansion of human cohorts and data repositories and enabled opportunities to predict disease risk, promote early diagnosis and d…

Nature Immunology, Published online: 17 August 2026; doi:10.1038/s41590-026-02636-x Author Correction: IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation

Nature Immunology, Published online: 17 August 2026; doi:10.1038/s41590-026-02626-z Endothelial cells form the cell migration highways between organs. New results demonstrate that NOD2-dependent microbial sensing by these structural cells promotes antigen-specific T cell accumulation in gut-associated lymphoid tissues and protective mucosal immunity.

Nature Immunology, Published online: 17 August 2026; doi:10.1038/s41590-026-02621-4 A comprehensive atlas of tissue-resident immune cells reveals where disease-risk variants regulate gene expression, helping connect genome-wide association study signals to disease mechanisms.

Nature Immunology, Published online: 17 August 2026; doi:10.1038/s41590-026-02625-0 Notch2 deletion in dendritic cells (DCs), already known to impair type 2a DC development and intestinal immunity, is now demonstrated to promote dysbiosis and unleash inflammatory AXL-expressing type 3 DCs, driving preclinical autoimmunity.

Nature Immunology, Published online: 14 August 2026; doi:10.1038/s41590-026-02606-3 Belz and colleagues show that Peyer’s patch M cells are required for ILC3 localization, proliferation and IL-22 production within the dome epithelium.

Nature Immunology, Published online: 14 August 2026; doi:10.1038/s41590-026-02623-2 In the context of a Public Health Emergency of International Concern, such as the Bundibugyo virus outbreak, the research community requires rapid access to information to guide an effective response. Evidence mapping brings together the available knowledge in a field into a single, organized resource, enabling re…

Nature Immunology, Published online: 14 August 2026; doi:10.1038/s41590-026-02620-5 A mechanistic understanding of how regulatory T cell plasticity is controlled remains lacking. A study shows that TIF1γ modulates this plasticity by restraining β-catenin signaling.

Nature Immunology, Published online: 14 August 2026; doi:10.1038/s41590-026-02629-w Research on SARS-CoV-2 shows that effective immunity can arise from a balance between recalling existing immune memory and generating new variant-specific antibodies, with important implications for designing future vaccines.

Nature Immunology, Published online: 14 August 2026; doi:10.1038/s41590-026-02613-4 Updated SARS-CoV-2 boosters broaden humoral immunity by recalling cross-reactive antibodies and eliciting new less cross-reactive Omicron type-specific antibodies that target distinct RBD epitopes and more potently neutralize recent variants.

Nature Immunology, Published online: 12 August 2026; doi:10.1038/s41590-026-02617-0 The authors provide a multiomic single-cell and spatial atlas of Crohn’s disease, focusing on the crosstalk between immune and stromal cells and heterogeneity around mucosal lesions.

Nature Immunology, Published online: 11 August 2026; doi:10.1038/s41590-026-02614-3 MDA5 detects double-stranded RNA during viral infections. This work shows that MDA5 binds aberrant host RNA induced during viral infection. Rescue of aberrant cytoplasmic RNA during infection abrogated MDA5 activation.

Nature Immunology, Published online: 11 August 2026; doi:10.1038/s41590-026-02603-6 This study identifies TIF1γ as a critical regulator of regulatory T cell stability during inflammation. By restraining β-catenin–TCF7 signaling, TIF1γ preserves Foxp3 expression, prevents inflammatory reprogramming and maintains immune tolerance.

Nature Immunology, Published online: 11 August 2026; doi:10.1038/s41590-026-02607-2 Ringham et al. identify immunomodulatory cancer-associated fibroblasts that influence regulatory T cell dynamics in lung cancer.