Nature Immunology, Published online: 01 September 2026; doi:10.1038/s41590-026-02637-w HIV reservoir cells are traditionally considered invisible to host immune responses due to viral latency. This work challenges this view by demonstrating that HIV persistence during long-term antiretroviral therapy is strongly influenced by KIR2DL1-educated NK cells.
Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy
Mathias Lichterfeld