Nature Biomedical Engineering

Nature Biomedical Engineering, Published online: 10 September 2026; doi:10.1038/s41551-026-01810-8 Author Correction: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Nature Biomedical Engineering, Published online: 28 August 2026; doi:10.1038/s41551-026-01785-6 This Perspective argues that biological discovery and drug development should be linked in a continuous data feedback loop that iteratively refines therapeutic hypotheses, drug design and patient stratification across discovery and clinical stages.

Nature Biomedical Engineering, Published online: 09 September 2026; doi:10.1038/s41551-026-01790-9 A generative protein design workflow addresses important challenges with de novo protein engineering of chimaeric antigen receptors (CARs) to improve targeting of proteins important in cancer and create more effective CAR T therapies.

Nature Biomedical Engineering, Published online: 26 August 2026; doi:10.1038/s41551-026-01766-9 We present a multiple-instance learning framework that aggregates patch-level features into reliable slide-level predictions through the use of random sampling at both patch and feature levels. Our approach enables large-batch optimization and consistent performance gains across 35 clinical tasks and 4…

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01779-4 This large-scale study of white matter structural connectivity during development reveals biomarkers associated with attention deficit hyperactivity disorder in youth that track symptom trajectories and predict differential treatment response.

Nature Biomedical Engineering, Published online: 09 September 2026; doi:10.1038/s41551-026-01792-7 Generative artificial intelligence (AI) has revolutionized protein engineering and has enabled de novo design of protein binders against dozens of target antigens. Our study combines AI-assisted binder design, binder integration into chimaeric antigen receptor (CAR) constructs and scalable in vitro …

Nature Biomedical Engineering, Published online: 07 September 2026; doi:10.1038/s41551-026-01794-5 Author Correction: A base editor for the long-term restoration of auditory function in mice with recessive profound deafness

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01782-9 A protein engineering strategy enables nitric oxide-triggered reactivation of proteins using genetically encoded caged amino acids, allowing inflammation-localized control of protein activity, viral gene delivery and biosensing in vivo.

Nature Biomedical Engineering, Published online: 14 August 2026; doi:10.1038/s41551-026-01778-5 The potential for machine learning to reshape the medical landscape is vast, and we are in the midst of an explosion in tool development. In this Focus issue, we share both critical and forward-looking insights from experts on artificial intelligence in medicine and emphasize how thoughtful engineering…

Nature Biomedical Engineering, Published online: 11 August 2026; doi:10.1038/s41551-026-01762-z This Perspective assesses the role of foundation models as clinical tools and introduces real-world evaluation and assessment of foundation models (REAL-FM), a framework for assessing data, technical readiness and clinical value towards responsible artificial intelligence.

Nature Biomedical Engineering, Published online: 12 August 2026; doi:10.1038/s41551-026-01760-1 TRICARE is a deep-learning triage framework that serves to enhance the benefits of volumetric imaging for improved diagnostics without increasing pathologist workloads by identifying high-risk two-dimensional cross sections in three-dimensional pathology datasets.

Nature Biomedical Engineering, Published online: 10 August 2026; doi:10.1038/s41551-026-01783-8 Author Correction: The evolving role of cytokines for CAR-T cell manufacturing and beyond

Nature Biomedical Engineering, Published online: 05 August 2026; doi:10.1038/s41551-026-01765-w Engineered lipid nanoparticles enable CD34-targeted delivery and in vivo editing of haematopoietic stem and progenitor cells while preserving haematopoiesis.

Nature Biomedical Engineering, Published online: 07 August 2026; doi:10.1038/s41551-026-01742-3 This Perspective explores and outlines how causal graph neural networks can impact the future of artificial intelligence in healthcare, from diagnostics to causal digital twins.

Nature Biomedical Engineering, Published online: 13 August 2026; doi:10.1038/s41551-026-01749-w Key tissue features shared by fibrotic diseases are distilled into clear design rules for human in vitro models, with practical guidance on choosing cells, matrices and platforms for mechanistic studies and drug testing.

Nature Biomedical Engineering, Published online: 14 August 2026; doi:10.1038/s41551-026-01775-8 A cell encapsulation strategy inspired by the biological development of the zona pellucida enables the spontaneous formation of thin capsules on cell surfaces. Encapsulated islets were successfully used to achieve normoglycaemia in diabetic mice.

Nature Biomedical Engineering, Published online: 17 July 2026; doi:10.1038/s41551-026-01758-9 Biomedical engineers are poised to meet urgent unmet needs in women’s health. We share our excitement about research in women’s health and our plans to champion such advances in our pages.

Nature Biomedical Engineering, Published online: 10 July 2026; doi:10.1038/s41551-026-01752-1 Author Correction: The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency

Nature Biomedical Engineering, Published online: 13 July 2026; doi:10.1038/s41551-026-01740-5 A foundation model for magnetic resonance imaging (MRI) with large-scale multi-sequence pretraining, MARS, overcomes limitations in image heterogeneity to enable versatile real-world multi-sequence MRI analysis on diverse anatomical structures.

Nature Biomedical Engineering, Published online: 17 July 2026; doi:10.1038/s41551-026-01763-y Nanosensor-integrated catheters for chemical mapping of bladder cancer biomarkers